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Introduction The debate remains unresolved about whether an open (Milligan-Morgan) or closed (Ferguson) approach is superior for hemorrhoidectomy. Advocates from both groups state that each has its own set of advantages and disadvantages. In light of this, we intend to share our experience by comparing the two in terms of their post-operative outcomes. This study aims to compare open (Milligan-Morgan) and closed (Ferguson) hemorrhoidectomy in terms of post-operative outcomes. Materials and methods This retrospective study was carried out at the Department of Surgery, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. A total of 137 patients who underwent hemorrhoidectomy from January 1, 2022, to May 31, 2024, were enrolled. Post-operative outcomes were noted in terms of surgical site infection (SSI), excessive bleeding, and visual analog scale (VAS) pain score. Data were analyzed using IBM SPSS Statistics for Windows, Version 25 (Released 2017; IBM Corp., Armonk, NY, USA). Results A total of 137 patients were enrolled in the study, with 93 (67.9%) undergoing Milligan-Morgan (open) hemorrhoidectomy and 44 (32.1%) undergoing the Ferguson (closed) procedure. The mean age in the open group was 46.87 ± 10.79 years, compared to 44.59 ± 9.06 years in the closed group. Male participants comprised 59 (63.4%) in the open group and 19 (43.2%) in the closed group. SSI was observed in 32 patients (23.3%); 22 (68.8%) were from the open group, and 10 (31.3%) were from the closed group (p-value, 0.905). Hemorrhage was recorded in 34 patients (15.3%), with 21 (61.8%) in the open group and 13 (38.2%) in the closed group (p-value, 0.378). The mean post-operative VAS pain score was 3.76 ± 1.79 for the open technique versus 4.07 ± 1.37 for the closed technique, respectively (p-value, 0.321). Conclusion Though the SSI and hemorrhage rates were higher with the Milligan-Morgan technique than with the Ferguson technique, the mean post-operative VAS score was also higher with the Milligan-Morgan procedure. However, none of the differences was found to be statistically significant.
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http://dx.doi.org/10.7759/cureus.75012 | DOI Listing |
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Outpatient, Third Xiangya Hospital, Central South University, Changsha 410013.
Objectives: Urinary calculi are characterized by a high recurrence rate, and patients' adherence to self-management after discharge directly affects health outcomes. Traditional offline follow-up models often face problems such as poor compliance and uneven allocation of medical resources, making it difficult to meet individualized health management needs. Remote follow-up provides a novel solution to optimize long-term management, improve health literacy, and enhance clinical outcomes.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Cardiovascular Medicine, Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha 410005.
Objectives: The Charlson comorbidity index reflects overall comorbidity burden and has been applied in cardiovascular medicine. However, its role in predicting in-hospital mortality in patients with acute myocardial infarction (AMI) complicated by ventricular arrhythmias (VA) remains unclear. This study aims to evaluate the predictive value of the Charlson comorbidity index in this setting and to construct a nomogram model for early risk identification and individualized management to improve outcomes.
View Article and Find Full Text PDFNanoscale Horiz
September 2025
Theoretical Chemical Physics Group, Research Institute for Materials Science and Engineering, University of Mons, 20 Place du Parc, Mons B-7000, Belgium.
Two-photon spontaneous emission (TPSE) is a second-order quantum process with promising applications in quantum optics that remains largely unexplored in molecular systems, which are usually very inefficient emitters. In this work, we model the first molecular two-photon emitters and establish the design rules, highlighting their differences from those governing two-photon absorbers. Using both time-dependent density functional theory and Pariser-Parr-Pople calculations, we calculate TPSE in three π-conjugated molecules and identify a dominant pathway.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
August 2025
School of Traditional Chinese Medicine, Henan University of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Objectives: To investigate the impact of prenatal fear stress on placental amino acid transport and emotion and cognition development in offspring rats.
Methods: Thirty pregnant Wistar rats were randomized equally into control and fear stress (induced using an observational foot shock model) groups. In each group, placental and serum samples were collected from 6 dams on gestational day 20, and the remaining rats delivered naturally and the offspring rats were raised under the same conditions until 8 weeks of age.
Turk J Pharm Sci
September 2025
Hacettepe University Faculty of Pharmacy, Department of Pharmacy Management, Ankara, Türkiye.
Objectives: Corporate social responsibility (CSR) is defined as companies voluntarily taking action with their resources to help solve some of the social, economic, and environmental problems of the society in which they operate. This study aimed to reveal the current status of CSR projects in the pharmaceutical industry, which are strategically important on a global scale.
Materials And Methods: The study was conducted between June and December 2019 using a structured online survey.