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Melatonin has become a popular choice for managing insomnia and sleep-related issues due to its effectiveness in promoting sleep and its minimal risk of side effects. This has led many individuals to opt for over-the-counter melatonin as an alternative to traditional sleep medications. Recent research indicates that melatonin not only aids in addressing sleep problems but also enhances muscle recovery and performance, thereby improving daytime functioning, particularly among athletes. In the United States, the prevalence of melatonin supplement usage has risen significantly from 0.08% in 2005-2006 to 0.28% in 2017-2018. Individuals with conditions such as heart failure, hypertension, coronary heart disease, and cardiovascular risk factors like diabetes and obesity typically exhibit lower levels of melatonin in their blood at night. This deficiency increases the likelihood of experiencing adverse cardiac events. Studies have highlighted melatonin's role not only in regulating sleep but also in safeguarding against cardiovascular diseases by influencing various cardiovascular functions. In summary, the increasing utilization of melatonin underscores its recognized efficacy in mitigating sleep disturbances, with emerging evidence suggesting potential benefits for cardiovascular health. As ongoing research explores additional therapeutic avenues, the multifaceted impact of melatonin emphasizes its significance in promoting overall well-being.
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http://dx.doi.org/10.1097/CRD.0000000000000822 | DOI Listing |
Pediatr Dermatol
September 2025
Harvard Medical School, Boston, Massachusetts, USA.
Background/objectives: Children with atopic dermatitis (AD) frequently experience sleep disturbances. Melatonin, an over-the-counter supplement, is increasingly used in the general pediatric population; however, its prevalence and perceived effectiveness in children with AD remain unclear.
Methods: Caregivers of pediatric patients (ages 1-17 years) with physician-diagnosed AD completed surveys on melatonin use, Patient Oriented Eczema Measure (POEM), and age-appropriate sleep questionnaires.
Plant Physiol Biochem
August 2025
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address:
The PR10 (Pathogenesis-Related Protein 10) family plays a crucial role in plant defense and growth regulation, with unique hydrophobic cavities that bind various ligands, including phytohormones and alkaloids. Among them, Norcoclaurine Synthases (NCS) are key enzymes in benzylisoquinoline alkaloid (BIAs) biosynthesis, catalyzing the Pictet-Spengler reaction to form the precursor (S)-norcoclaurine. However, the evolutionary origins and functions of the PR10 family in BIA biosynthesis remain unclear.
View Article and Find Full Text PDFTissue Cell
September 2025
Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin 300052, China. Electronic address:
Cholestasis is a pathological state characterized by the dysfunction of bile acid flow, which could lead to liver fibrosis, cirrhosis, and even liver failure, but its therapeutic agents are limited. The aim of this study was to investigate the therapeutic potential and underlying mechanism of melatonin on cholestatic liver injury. C57BL/6 J mice were fed with 0.
View Article and Find Full Text PDFCell Biochem Biophys
September 2025
Medical Biotechnology Research Center, School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran.
In cardiovascular research, melatonin has shown promise in exhibiting antifibrotic properties and modulating endoplasmic reticulum (ER) stress. However, the exact mechanism by which it influences myocardial fibrosis has not been fully clarified. Therefore, this research aimed to investigate the inhibitory effect of melatonin on the progression of myocardial fibrosis through a mechanism involving the BIP/PERK/CHOP signaling pathway, both in silico and in vivo experimental models.
View Article and Find Full Text PDFPhysiol Plant
September 2025
Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Stress, Development and Signaling in Plants, Estación Experimental del Zaidín, Spanish National Research Council (CSIC), Granada, Spain.
Waterlogging, increasingly intensified by climate change, limits oxygen availability in the root zone, disrupting carbon and sugar metabolism, leading to energy deficits and oxidative stress that ultimately impair plant growth and productivity. Melatonin, a versatile signaling molecule, mitigates waterlogging-induced stress by enhancing anaerobic respiration and fermentation under oxygen-deprived conditions, upregulating stress-responsive genes, and restoring energy balance through optimized sugar metabolism. It also reduces oxidative damage by strengthening the antioxidant defense system and further improves stress tolerance by modulating phytohormone signaling and influencing rhizosphere microbiome dynamics.
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