Enhancing cellulose-rich polylactic acid (PLA)-rice residue-reinforced sustainable biocomposites: Influence of chemical pretreatments on strengthening the thermomechanical properties of biocomposite materials.

A systematic study was conducted to optimize chemical pretreatments of rice husk (RH) and rice straw (RS) fibers for reinforcing polylactic acid (PLA) biocomposites. Using a Central Composite Design (CCD), the effects of NaOH, HCl, and H₂SO₄ treatments were evaluated over a range of concentration (0.35 to 0.

Lysergic Acid Diethylamide (LSD) and the Heart: Exploring the Potential Impacts of LSD on Cardiovascular Function.

Lysergic acid diethylamide (LSD) is an ergot-derived psychedelic agent that produces perceptual and psychic effects of heightened sensations by acting on the dopaminergic, adrenergic, and serotonergic pathways in the brain and periphery, with 5-hydroxytryptamine 2A (5-HT2A) as the primary target molecule. Its action on these receptors in the central nervous system is comparatively well studied with respect to the psychedelic effects; however, there is speculative evidence of cardioprotective effects in the current literature attributed to the usage of this substance, even though acute ingestion causes tachycardia and hypertension, just like other psychedelics. Larger recreational doses of the drug can lead to cardiovascular and cerebrovascular incidents, but chronic peripheral antagonism of 5-HT2A receptors by the drug reduces atherosclerotic and thrombotic processes due to a reduction in platelet aggregation and vascular smooth muscle cell proliferation.

Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial.

Evidence is lacking for guiding optimal combination hypertension therapy in South Asian patients. Here we investigated the blood pressure (BP)-lowering efficacy and safety of three commonly recommended antihypertensive dual combinations in a multicenter, single-blinded trial conducted in India. We randomized Indians aged 30-79 years (mean age, 52 years) with mean sitting systolic blood pressure (SBP) of 150-179 mmHg on no treatment or an SBP of 140-159 mmHg on monotherapy 1:1:1 to a single-pill combination of amlodipine-perindopril, perindopril-indapamide or amlodipine-indapamide.

Using Machine Learning and Predictive Artificial Intelligence to Determine Cage Change Frequency for Mice Housed in Individually Ventilated Cages and Drive Vivarium Operational Efficiency.

A standard 2-wk cage change frequency for individually ventilated mouse cages is used in many research facilities, with negligible effects on animal health and welfare. However, these techniques rely on subjective visual evaluations and often require spot changes. In this study, we describe the use and validation of digital monitoring technology to objectively determine the necessity of a cage change for mice.

Evaluation of Sentinel-Free Soiled Bedding as a Replacement for Direct Sampling in PCR Detection of Rodent Pathogens during Quarantine.

Establishing a screening method for rodent pathogens is an integral component of an institution's rodent health surveillance program. Most rodent quarantine programs use direct colony sampling (DCS) from live animals for pathogen PCR testing. DCS may elicit undue stress to the animal and be time consuming, contingent on the number of quarantined animals.

Role of hs-CRP in Post-MI Sequelae: Insights into Mechanisms and Clinical Significance.

High-sensitivity C-reactive protein (hs-CRP) is a key marker of inflammation, predominantly produced by hepatocytes and various tissues, including intracardiac tissue, atherosclerotic plaques, and vascular smooth muscles. The biomarker serves as a crucial element of innate immunity and rises in response to various disease processes, including infections and cancers. This rise is triggered by the release of cytokines, primarily interleukin-6, tumor necrosis factor, and interleukin-1β.

Riding the wave of innovation: nanotechnology in nucleic acid-based cancer therapy.

Nucleic acids have lately been explored as one of the significant strategies for cancer treatment. Despite their potential as a promising therapeutic tool in cancer therapy, these often face challenges of rapid degradation, insufficient cellular uptake, and poor targeting abilities. In this regard, nanotechnology has revolutionized nucleic acid-based cancer therapy.

Mediastinal haematoma following permanent pacemaker insertion.

Mediastinal haematoma post permanent pacemaker insertion (PPI) is a rare complication. We report the case of a woman in her 60s with symptomatic complete heart block, who developed symptoms of respiratory distress following the PPI procedure. Radiological investigations revealed a large mediastinal haematoma.

Microwaves in clean energy technologies.

Energy in the microwave spectrum is increasingly applied in clean energy technologies. This review discusses recent innovations using microwave fields in hydrogen production and synthesis of new battery materials, highlighting the unique properties of microwave heating. Key innovations include microwave-assisted hydrogen generation from water, hydrocarbons and ammonia and the synthesis of high-performance anode and cathode materials.

QbD and green metric based HPLC method development and validation of bromocriptine mesylate in bulk product and biological samples.

Bromocriptine mesylate (BM) is a well-established antiparkinsonian drug, yet its analytical methodologies remain limited in terms of efficiency, cost-effectiveness, and reproducibility from commercial product and biological samples. We aimed at systematic analytical quality by design-assisted method development for routine quantitative assessment. Initially, various plausible variables (peak area, retention time, tailing factor, and plates) were screened using Ishikawa fishbone method.

Review on the synergistic mechanisms in harnessing rice residue-derived cellulose nanocrystals for sustainable water purification and wastewater treatment.

The review explores the innovative use of rice residue for developing Cellulose nanocrystals and reinforcement applications of CNCs for wastewater treatment. Rice residue, rich in lignocellulose components like cellulose, hemicellulose, and lignin, presents a sustainable resource for biocomposite fabrication. The review highlights the significant challenges of managing rice residue, particularly the environmental impact of its open field burning, which contributes to severe air pollution and health risks.

Investigation of spatially varying relationships between cadmium accumulation and potential controlling factors in the topsoil of island of Ireland based on spatial machine learning approaches.

Background: Cadmium (Cd) contamination in soils is a pressing environmental issue due to its toxicity and persistence. Given the diverse geological formations and intensive agricultural activities in Ireland, understanding the distribution and sources of soil Cd is particularly important.

Methods: This study used multiple GIS-based and spatial machine learning (SML) techniques to investigate the spatial distribution and controlling factors of Cd in 16,783 topsoil samples across the island of Ireland.

A New Paradigm in Hospital Medicine: Evaluating the Effects of Geographical Cohorting on Health Care Delivery.

Background: Geographical cohorting in hospital settings represents a significant shift from traditional patient rounding practices and aims to enhance the efficiency of health care delivery. This model assigns hospitalists to a particular inpatient unit, where most of their patients are located. While this model has several benefits, including streamlining health care procedures, optimizing resource allocation, and fostering better provider communication, its implementation is not without its challenges.

Effective Eradication of Mouse Norovirus and Helicobacter spp. in Laboratory Mice (Mus musculus) via Iodine Immersion and Cross-Fostering Technique.

Eradication of pathogens from mouse colonies is crucial for scientific research reproducibility and animal welfare. The previously described techniques for eradicating pathogens by rederivation through embryo transfer or caesarian technique can be costly and technically challenging. The objective of our study was to assess the efficacy of iodine immersion combined with cross-fostering for eradicating murine norovirus (MNV) and Helicobacter spp.

Loeffler's Syndrome Induced by the Transmigration of Strongyloides stercoralis to the Lungs: A Case Report and Literature Review.

Loeffler's syndrome is a rare, benign respiratory disease usually associated with peripheral eosinophilia, first described by Wilhelm Loeffler in 1932. It is caused by the larvae of helminths such as hookworms, , and S that transmigrate through the lungs during the active phase of infection. We present a case of a 53-year-old man who complained of a productive cough with intermittent hemoptysis and left-sided posterior chest pain.

Oesophageal submucosal haematoma in a patient with acute coronary syndrome.

A man in his mid-70s presented with recent-onset angina. An ECG revealed ST-segment depression, and he was started on treatment under the diagnosis of acute coronary syndrome. 12 hours after admission, he developed haematemesis and dysphagia.

Green RP-HPLC method for the estimation of carfilzomib in bulk, protein nanocarriers and human plasma: Application of chemometrics and Monte-Carlo simulations.

Carfilzomib is a tetrapeptide epoxyketone that has shown potential clinical outcomes in the treatment of multiple myeloma. However, inaccuracies in quantifying such peptide drug products have arisen due to poor stability, low solubility, time-consuming techniques, complex physicochemical properties, and use of non-green solvents with less recyclability. This provides a substantial urge to develop an ecological and sensitive analytical method for quantifying peptide drugs from matrix formulation and biological samples in early as well as lateral stages of product development in pharma industries.

Treatment optimisation for blood pressure with single-pill combinations in India (TOPSPIN) - Protocol design and baseline characteristics.

Background: The burden of over 300 million individuals living with hypertension in India is increasing steadily. Most current guidelines recommend initial combination therapy for effective blood pressure (BP) control. However, there is no randomised evidence to inform which combinations to use in the South Asian population, who account for over one-quarter of the world's population.

Exposure and probable ingestion of fluoride through non-dietary edible items from Panipat (NCR), India.

The present study revealed that various non-dietary items like pan masala, chewing tobacco, betel nuts, and toothpaste may contribute to the fluoride burden of the human body. In this line, an attempt was made to analyze the fluoride content of non-dietary items collected from Panipat City of Haryana. The study depicts that intake of pan masala, chewing tobacco, betel nuts, and toothpaste expose the consumers to 21.