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http://dx.doi.org/10.3928/23258160-20240923-01 | DOI Listing |
Cancers (Basel)
August 2025
Department of Neurology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA 02129, USA.
Maximal safe surgical resection remains a critical component of glioblastoma (GBM) management, improving both survival and quality of life. However, complete tumor removal is hindered by the infiltrative nature of GBM and its proximity to eloquent brain regions. Fluorescence-guided surgery (FGS) has emerged as a valuable tool to enhance intraoperative tumor visualization and optimize resection outcomes.
View Article and Find Full Text PDFAdv Mater
August 2025
Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.
Near-infrared-II (NIR-II) fluorescence imaging has transformed biomedical imaging by providing low autofluorescence, deep tissue penetration, and superior spatial resolution, essential for precise in vivo biological visualization. However, developing NIR-II-emitting molecular fluorophores with high brightness remains challenging due to the difficulty in simultaneously achieving high absorption coefficients and excellent fluorescence emission in aggregated states. This study addresses these challenges at both the molecular and aggregate levels through a series of donor-acceptor-donor (D-A-D) configured small molecules.
View Article and Find Full Text PDFOphthalmol Sci
July 2025
Doheny Eye Institute, University of California-Los Angeles, Los Angeles, California.
Purpose: To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD).
Design: Longitudinal cohort study.
Subjects: The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, of which 108 eyes were graded to have RPD.
ACS Med Chem Lett
August 2025
Graduate School of Life Science, Hokkaido University, Sapporo 001-0021, Japan.
Fluorescence-guided tumor detection using tumor-targeting imaging agents is critical for achieving complete surgical resection with tumor-free margins. Shortwave infrared (SWIR, 900-1400 nm) fluorescence imaging enables deeper tissue penetration due to reduced tissue autofluorescence and scattering relative to conventional visible (400-700 nm) and near-infrared (NIR, 700-900 nm) imaging. In this study, a series of estrogen receptor (ER)-targeting imaging probes were developed by conjugating the anticancer drug-based ligand tamoxifen (TAM) with the FDA-approved indocyanine green (ICG), yielding ICG-TAM and its π-conjugated extended analogues, ICG-C9-TAM and ICG-C11-TAM.
View Article and Find Full Text PDFResearch (Wash D C)
August 2025
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Afterglow imaging offers exceptional signal-to-background ratios (SBRs) by circumventing real-time excitation and autofluorescence, yet conventional systems rely on visible-light excitation, limiting tissue penetration and signal intensity. Here, we report near-infrared-excitable organic afterglow nanoparticles (NOANPs) that leverage singlet oxygen (O)-mediated energy transfer to achieve prolonged, high-intensity emission with minimal photobleaching. The nanoparticles integrate a near-infrared-photoactive sensitizer (NAM-0), which generates abundant O under 808-nm laser excitation, and a triplenet-anthracene derivative (TD) as the afterglow substrate, which converts O into sustained luminescence.
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