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http://dx.doi.org/10.1021/envhealth.3c00134 | DOI Listing |
Curr Microbiol
September 2025
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation.
View Article and Find Full Text PDFTrends Pharmacol Sci
September 2025
Department of Biosciences and Bioinformatics & Suzhou Municipal Key Lab of Biomedical Sciences and Translational Immunology, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China; Biomedical Research Center, School of Science, Engineering and Environment, University of Salford, Manch
Regulatory T cells (Tregs) play a pivotal role in maintaining immune tolerance and sustaining immunological homeostasis. Emerging evidence indicates that Treg characteristics and functional alterations can significantly contribute to the pathogenesis of autoimmune diseases including type 1 diabetes mellitus (T1DM). Notably, recent studies have established a positive correlation between diminished numbers of Tregs and the onset of T1DM.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Institute of Entomology, Guizhou University, Guizhou Key Laboratory of Agricultural Biosecurity, Guiyang 550025, China.
The Toll signaling pathway serves as a crucial regulatory mechanism in the insect innate immune system, playing a pivotal role in defending against pathogenic microorganisms. However, the specific functions of aphids' unique immune system and Toll signaling pathway remain poorly understood. In this study, we systematically analyzed 12 key genes associated with the Toll signaling pathway in Myzus persicae.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China. Electronic address:
The extensive use of highly toxic and residual pesticides has a significant negative impact on agricultural production and the ecological environment. The development of new green antiviral agents has become a major demand for ensuring the development of green ecological agriculture. Indole alkaloids are widely present in nature and have diverse biological activities.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Shanxi Key Laboratory of Nucleic Acid Biopesticides, Institute of Applied Biology, Shanxi University, Taiyuan, Shanxi 030006, China; School of Synthetic Biology, Shanxi University, Taiyuan, Shanxi 030006, China; School of Life Science, Shanxi University, Taiyuan, Shanxi 030006, China.
Glutamine: fructose-6-phosphate aminotransferase (GFAT) is the first rate-limiting enzyme in the hexosamine biosynthetic pathway, which plays a crucial role in various biological processes, including chitin metabolism in insects. Locusta migratoria, a widespread and highly destructive agricultural pest, poses a significant threat due to its rapid reproduction and long-distance migration. In this study, we identified and characterized LmGFAT as a key regulator of locust development.
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