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| http://dx.doi.org/10.1016/j.phrs.2024.107463 | DOI Listing |
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Network pharmacology and metabolomics reveal mathurameha, a Thai traditional Anti-Diabetic formula, enhances glucose metabolism through PI3K-AKT/AMPK/GLUT4 pathway modulation.
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Medicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Traditional herbal formulations offer promising avenues for diabetes management by targeting multiple molecular pathways. Mathurameha (MT), a polyherbal preparation, has been historically used for its antidiabetic potential. However, its molecular mechanisms remain largely unexplored.
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Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Background: The activation of brown adipose tissue (BAT) or the browning of white adipose tissue (WAT) represents a promising therapeutic strategy for obesity. Arctiin (ARC), a lignan compound known for its anti-inflammatory, anti-tumor, and hypoglycemic properties, has not been fully elucidated regarding its effects and mechanisms on obesity.
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Department of HBP Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, People's Republic of China.
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Pharmacology Division, CSIR - Indian Institute of Integrative Medicine, Jammu, India.
Two new (-)-parairesinol (), lappaol G (), and three known (, , and ) dibenzyl--butyrolactone lignans were isolated from the Indian Himalayan herb . Their structures were characterised by NMR and mass data analysis. cytotoxic study revealed that arctiin () showed promising growth inhibition across seven human cancer cells, with potent activity against Mia-PaCa-2 cells.
View Article and Find Full Text PDFArctiin Inhibits Hyperglycemia-Induced Oxidative Stress by Activating the Nrf2/HO-1 Signaling Pathway to Treat Type 2 Diabetic Osteoporosis.
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College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China.
Arctiin (ARC), a primary component of burdock (Arctium lappa L.), is widely recognized as a traditional herb and nutritional supplement in Asia. This study set out to explore its potential impact on type 2 diabetic osteoporosis (T2DOP).
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