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http://dx.doi.org/10.1007/s10143-024-02917-9 | DOI Listing |
Adv Sci (Weinh)
September 2025
Department of Spine Surgery, The 3rd Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, P. R. China.
Fibrotic scarring remains a critic obstacle to axonal regeneration after spinal cord injury (SCI). Current strategies primarily concentrating on eliminating extracellular matrix (ECM) components neglect their dispensable roles in maintaining tissue integrity. Here, it is reported that the mechanical strength of an integrated hydrogel composed of hyaluronic acid-graft-dopamine and HRR peptide directs fibroblast migration, determining ECM deposition.
View Article and Find Full Text PDFAdv Mater
September 2025
State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.
Regulating the differentiation of implanted stem cells into neurons is crucial for stem cell therapy of traumatic brain injury (TBI). However, due to the migratory nature of implanted stem cells, precise and targeted regulation of their fate remains challenging. Here, neural stem cells (NSCs) are bio-orthogonally engineered with hyaluronic acid methacryloyl (HAMA) microsatellites capable of sustained release of differentiation modulators for targeted regulation of their neuronal differentiation and advanced TBI repair.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Clinically, even in patients diagnosed with non-obstructive azoospermia, spermatogenesis may be present in some seminiferous tubules, which gives the patient hope of having biological offspring of his own. However, there is still a blank for high-precision detection technologies to support accurate diagnosis and effective treatment. In this work, we successfully developed a minimally invasive fine needle detection memristive device that features a structure composed of Ag/CH-MnO/FTO by utilizes the organic-inorganic heterojunction as functional layer.
View Article and Find Full Text PDFNeurosci Biobehav Rev
September 2025
Instituto de Neurobiología, Universidad Nacional Autónoma de México.
Epigenetic mechanisms are essential in neurogenesis during development and adulthood. DNA methylation, histone post-translational modifications, and non-coding RNAs regulate gene expression to maintain the neural stem cell pool and direct the fate of newborn neurons by modulating cell proliferation, migration, differentiation, maturation, and survival. Adult neurogenesis exhibits bidirectional interactions with non-social and socio-sexual factors such as sexual behavior, mate recognition, pair bonding, parental behavior, and offspring recognition.
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