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Life cycle assessment (LCA) is a broadly used method for quantifying environmental impacts, and life cycle impact assessment (LCIA) is an important step as well as a major source of uncertainties in LCA. Characterization factors (CFs) are pivotal elements in LCIA models. In China, the health loss due to ambient PM is an important aspect of LCIA results, which, however, is generally assessed by adopting CFs developed by global models and there remains a need to integrate localized considerations and the latest information for more precise applications in China. In this study, we developed indigenized CFs for LCIA of health damage due to ambient PM in China by coupling the atmospheric chemical transport model GEOS-Chem, exposure-response model GEMM containing Chinese cohort studies, and the latest local data. Results show that CFs of four major PM precursors all exhibit significant interregional variation and monthly differences in China. Our results were generally an order of magnitude higher and show disparate spatial distribution compared to CFs currently in use, suggesting that the health damage due to ambient PM was underestimated in LCIA in China, and indigenized CFs need to be adopted for more accurate results in LCIA and LCA studies.
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http://dx.doi.org/10.1021/acs.est.3c08122 | DOI Listing |
Sud Med Ekspert
September 2025
Bureau of Forensic Medical Examination of the Department of Health Care of the City of Moscow, Moscow, Russia.
The article considers the main phases of traffic injury (TI) described by A.A. Solokhin in 1968 and their modern application in forensic medical and automotive examination.
View Article and Find Full Text PDFInflammopharmacology
September 2025
Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
The NOD‑like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a key molecular complex that amplifies inflammatory cascades by maturing interleukin‑1 beta (IL-1β) and interleukin‑18 (IL-18) and inducing pyroptosis. It serves as a major driver and co-driver of numerous diseases associated with chronic inflammation. Dysregulated NLRP3 activation contributes to the progression of disorders such as rheumatoid arthritis, inflammatory bowel disease, neurodegenerative diseases and atherosclerosis.
View Article and Find Full Text PDFInflamm Res
September 2025
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Cardiovascular diseases (CVDs) are a group of conditions that significantly affect human health and are among the leading causes of death and disability worldwide. Clinical trials and basic research have demonstrated that inflammation plays a pivotal role in the development of CVDs. The inflammasome is a critical component of the innate immune system, involved in various inflammatory responses to pathogens and tissue damage.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Department of Ophthalmology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Purpose: To explore the causal links between antihypertension drugs usage and age-related macular degeneration (AMD).
Methods: Multiple genetic analyses, including summary data-based Mendelian randomization (SMR), traditional MR, and colocalization analysis, were used to explore the causal associations between antihypertension drugs and AMD. Clinical data from the UK Biobank and the National Health and Nutrition Examination Survey (NHANES) was applied to refined risk assessment of specific antihypertensive medications in the context of AMD development.
Int J Ment Health Nurs
October 2025
Cukurova State Hospital, Adana, Turkey.
As in all other traumas, children and adolescents are more sensitive and vulnerable to the effects of earthquakes. This study aimed to understand the earthquake experiences of adolescent survivors. This study is a qualitative study in which the photovoice method was used.
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