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Objective: This study aims to comprehend the natural history of adolescent idiopathic scoliosis (AIS) patients and determine risk factors for facet joint bridging in adolescent-onset adult idiopathic scoliosis with thoracolumbar/lumbar (TL/L) curves.
Methods: We included 50 patients with residual AIS with TL/L curves (3 males, 47 females; age 41.5 ± 17.3 years, TL/L Cobb angle 59.4 ± 11.8°). They were >20 years old and diagnosed with AIS during their adolescence. Radiographic parameters were measured, and facet joint bridging was defined from axial computed tomography images.
Results: The sagittal vertical axis (SVA) significantly increased with age (r = 0.71, P < 0.01). Coronal Cobb angle of the TL/L curve, L4 tilt, C7 translation, lumbar lordosis (LL), pelvic incidence-LL, pelvic tilt, and thoracolumbar kyphosis were also correlated to age (P < 0.05). There were significant differences in age, SVA, pelvic incidence-LL, vertebral bridging, facet tropism, and apical vertebral rotation (AVR) between the facet joint bridging group (n = 10) and the non-facet joint bridging group (n = 40). In the multivariate logistic regression analysis, SVA, vertebral bridging, and AVR emerged as notable risk determinants for facet joint bridging. The threshold for facet joint bridging based on SVA was 2.1 cm (area under the curve: 0.801; sensitivity = 90%; specificity = 65%).
Conclusions: This research revealed that large SVA, the presence of vertebral bridging, and large AVR are associated with facet joint bridging in adolescent-onset adult idiopathic scoliosis patients with TL/L curves. The cutoff value for facet joint bridging based on SVA was 2.1 cm.
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http://dx.doi.org/10.1016/j.wneu.2024.08.042 | DOI Listing |
Water Res
September 2025
Key Lab of Groundwater Resources and Environment Ministry of Education, Jilin University, Changchun 130021, China; Jilin Provincial Key Laboratory of Water Resources and Water Environment, Jilin University, Changchun 130021, China; National and Local Joint Engineering Laboratory for Petrochemical Co
As an abundant natural mineral, pyrite presents a highly promising solution for sustainable groundwater remediation, owing to its distinct electron transfer properties. However, research on pyrite's remediation capabilities has often focused on isolated mechanisms, neglecting the complex interplay between the mineral's properties, the environmental matrix, and interfacial processes, thereby limiting comprehensive understanding of its efficacy and constraints. Herein, an integrated "mechanism-application-sustainability" framework is proposed to bridge this knowledge gap.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
September 2025
College of Materials Science and Engineering, Hainan University, Haikou, 570228, China. Electronic address:
Deep-sea hydrothermal vents are renowned for being among the most extreme environments on Earth. However, the mussel shells found in these vent sites demonstrate remarkable productivity, despite being subjected to high pressure as well as unusual levels of heavy metals, pH, temperature, CO, and sulphides. To comprehend how these mussels endure such extreme conditions, a systematic comparative study was conducted, focusing on the unique chemical composition, structural designs, and mechanical properties of hydrothermal vent mussels (Bathymodiolus aduloides) in comparison to shallow-water mussels (Mytilus edulis).
View Article and Find Full Text PDFUnderstanding musculoskeletal joints from a 3D multiscale perspective, from molecular to anatomical levels, is essential for resolving the confounding relationships between structure and pain, elucidating the intricate mechanisms regulating joint health and diseases, and developing new treatment strategies. Here, we introduce a musculoskeletal joint immunostaining and clearing (MUSIC) method specifically designed to overcome key challenges of immunostaining and optical clearing of intact joints. Coupled with large-field light sheet microscopy, our approach enables 3D high-resolution, microscale neurovascular mapping within the context of whole-joint anatomy without the need for image coregistration across various joints, including temporomandibular joints, knees, and spines, and multiple species, including mouse, rat, and pig.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Orthopedics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained synovial inflammation and the gradual destruction of joint structures. Although conventional T cells have historically been viewed as central to RA pathogenesis, increasing attention has recently focused on unconventional T cell subsets, such as natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, and gamma delta T (γδ T) cells. Functioning as a bridge between innate and adaptive immunity, these cells contribute to RA immunopathogenesis by producing cytokines, exerting cytotoxic effects, and interacting with various immune and stromal cells.
View Article and Find Full Text PDFEnviron Sci Technol
September 2025
State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
The rapid growth of natural-gas vehicles (NGVs) necessitates robust catalysts for the simultaneous abatement of methane (CH), nitrogen oxides (NO), and carbon monoxide (CO) under fluctuating exhaust compositions. We reported a site-engineered MnGa@In-CHA OXZEO catalyst in which indium was confined within an SSZ-13 framework, and GaO and MnO phases were uniformly dispersed on its exterior. MnO markedly enhanced redox capacity, driving NO → NO oxidation and lowering the activation energy for C-H bond cleavage in CH, while GaO tuned the Brønsted acidity and mediated electron transfer among In, Mn, and Ga centers.
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