Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: After spinal cord injury (SCI), a large number of survivors suffer from severe motor dysfunction (MD). Although the injury site is in the spinal cord, excitability significantly decreases in the primary motor cortex (M1), especially in the lower extremity (LE) area. Unfortunately, M1 LE area-targeted repetitive transcranial magnetic stimulation (rTMS) has not achieved significant motor improvement in individuals with SCI. A recent study reported that the M1 hand area in individuals with SCl contains a compositional code (the movement-coding component of neural activity) that links matching movements from the upper extremities (UE) and the LE. However, the correlation between bilateral M1 hand area excitability and overall functional recovery is unknown.
Objective: To clarify the changes in the excitability of the bilateral M1 hand area after SCI and its correlation with motor recovery, we aim to specify the therapeutic parameters of rTMS for SCI motor rehabilitation.
Methods: This study is a 12-month prospective cohort study. The neurophysiological and overall functional status of the participants will be assessed. The primary outcomes included single-pulse and paired-pulse TMS. The second outcome included functional near-infrared spectroscopy (fNIRS) measurements. Overall functional status included total motor score, modified Ashworth scale score, ASIA Impairment Scale grade, spinal cord independence measure and modified Barthel index. The data will be recorded for individuals with SCI at disease durations of 1 month, 2 months, 4 months, 6 months and 12 months. The matched healthy controls will be measured during the same period of time after recruitment.
Discussion: The present study is the first to analyze the role of bilateral M1 hand area excitability changes in the evaluation and prediction of overall functional recovery (including motor function and activities of daily living) after SCI, which will further expand the traditional theory of the predominant role of M1, optimize the current rTMS treatment, and explore the brain-computer interface design for individuals with SCI.
Trial Registration Number: ChiCTR2300068831.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193300 | PMC |
| http://dx.doi.org/10.1186/s12883-024-03705-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Ultrasound measurement of median nerve cross-sectional area (CSA) is widely used in carpal tunnel syndrome (CTS) diagnosis. This study compared 3 common measurement methods: A-B, Ellipse, and Trace to evaluate their reliability and accuracy.
Methods: Two observers (experienced hand surgeon and orthopedic surgery resident) measured median nerve CSA in 10 patients with suspected CTS.
Rostro-caudal TMS mapping of immediate transcranial evoked potentials reveals a pericentral crescendo-decrescendo pattern.
Neuroimage
September 2025
Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark, Kettegård Allé 30, 2650 Hvidovre, Denmark; Institute of Neuroscience, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N,
Background: We recently demonstrated that single-pulse TMS of the primary sensorimotor hand area (SM1) elicits an immediate transcranial evoked potential (iTEP). This iTEP response appears within 2-8 ms post-TMS, featuring high-frequency peaks superimposed on a slow positive wave. Here, we used a linear TMS-EEG mapping approach to characterize the rostro-caudal iTEP expression and compared it to that of motor-evoked potentials (MEPs).
View Article and Find Full Text PDFEffect of Surfactant Mixtures on the Evaporation Rate of Aqueous Sessile Droplets from Slightly Hydrophobic Substrates.
Langmuir
September 2025
ThAMeS Multiphase, Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.
The evaporation of surfactant-laden sessile droplets has widespread applications in both natural and technological contexts. This study explores the evaporation of droplets containing a nonionic surfactant (tristyrylphenol ethoxylates (EOT)), an anionic surfactant (sodium benzenesulfonate with alkyl chain lengths of C-C (NaDDBS)), and their mixtures at / mole ratios of 0.01, 0.
View Article and Find Full Text PDF[From the emergence of mpox in the Democratic Republic of the Congo to global health emergencies].
Med Sci (Paris)
September 2025
UMI233 TransVIHMI (Recherches translationnelles sur le VIH et les maladies infectieuses), Université de Montpellier, IRD, INSERM Unité 1175, Montpellier, France.
For a long time neglected, the mpox virus has caused two public health emergency declarations by the World Health Organization in just two years. Rapid detection and characterization of the viral strains involved are crucial for better control of the disease. Recent work on viral genome sequencing in the Democratic Republic of the Congo (DRC) has shown the emergence in 2023 of clade Ib, with sustained human-to-human transmission and rapid spread to several other non-endemic neighboring countries, as well as outside Africa.
View Article and Find Full Text PDFApplication of artificial muscle e-rubber for healthcare sensing: verification of measurement properties as a smart insole.
Front Bioeng Biotechnol
August 2025
Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Electroactive polymer (EAP) artificial muscles are gaining attention in robotic control technologies. Among them, the development of self-sensing actuators that integrate sensing mechanisms within artificial muscles is highly anticipated. This study aimed to evaluate the accuracy and precision of the sensing capabilities of the e-Rubber (eR), an artificial muscle developed by Toyoda Gosei Co.
View Article and Find Full Text PDF