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Two new acorane-type sesquiterpenoids, harzianes A and B ( and ), together with two known cyclonerodiol-type sesquiterpenoids (-) and four known sterols (-) were isolated from the endophytic , associated with the medicinal plant Pall. Compounds and were identified as a pair of heterotropic isomers by spectroscopic analysis (HR-ESI-MS, 1D and 2D NMR), and their absolute configurations were determined by ECD calculations. All compounds were tested for anti-inflammatory activity, however, none demonstrated such activity.
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http://dx.doi.org/10.1080/14786419.2024.2308001 | DOI Listing |
Phytochemistry
November 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China. Electronic address:
Eight previously undescribed sesquiterpenoids with different skeletons, designated as chlorholones A-H (1-8), including three noreudesmane-type sesquiterpenoids (1-3, the first discovery of this type in the genus), one germacrane-type sesquiterpenoid (4), one acorane-type sesquiterpenoid (5), two cadinene-type sesquiterpenoids (6-7) and one guaiane-type sesquiterpenoid (8), together with eight known sesquiterpenoids (9-16), were identified from the whole plant of Chloranthus holostegius. A combination of spectral analysis, electron circular dichroism calculations, and X-ray crystallography were employed in the structural characterization. Among the isolated compounds, 10 exhibited notable anti-inflammatory activity, showing significant inhibition of nitric oxide (NO) release in LPS-induced RAW 264.
View Article and Find Full Text PDFMar Drugs
December 2024
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Six new sesquiterpenes, including four eremophilane derivatives fureremophilanes A-D (-) and two acorane analogues furacoranes A and B ( and ), were characterized from the culture extract of the cold-seep derived fungus CS-280 co-cultured with autoclaved QDIO-4. All the six compounds were highly oxygenated especially and with infrequent epoxyethane and tetrahydrofuran ring systems. The structures of - were established on the basis of detailed interpretation of 1D and 2D NMR and MS data.
View Article and Find Full Text PDFJ Nat Prod
May 2024
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Naval Medical University, Shanghai 200433, People's Republic of China.
With the advancement of bioinformatics, the integration of genome mining with efficient separation technology enables the discovery of a greater number of novel bioactive compounds. The deletion of the key gene responsible for triterpene cyclase biosynthesis in the polar strain sp. D-1 instigated metabolic shunting, resulting in the activation of dormant genes and the subsequent production of detectable, new compounds.
View Article and Find Full Text PDFNat Prod Res
July 2025
School of Pharmacy, Anhui University of Chinese Medicine, Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei, P.R. China.
Two new acorane-type sesquiterpenoids, harzianes A and B ( and ), together with two known cyclonerodiol-type sesquiterpenoids (-) and four known sterols (-) were isolated from the endophytic , associated with the medicinal plant Pall. Compounds and were identified as a pair of heterotropic isomers by spectroscopic analysis (HR-ESI-MS, 1D and 2D NMR), and their absolute configurations were determined by ECD calculations. All compounds were tested for anti-inflammatory activity, however, none demonstrated such activity.
View Article and Find Full Text PDFNat Prod Res
March 2025
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Bioassay-guided fractionation of the isopropanol extract of the medicinal mushroom led to the isolation and characterisation of a new acorane-type sesquiterpenoid bauminene () and seven known compounds -. The planar structure of was elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR and HR-ESI-MS. The relative configuration of was determined by a combination of ROESY experiment, density functional theory calculation of C NMR, and DP4+ probability analysis, while the absolute configuration of was established by comparative electronic circular dichroism (ECD) spectra analysis.
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