Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders.

We conducted the largest genome-wide meta-analysis of borderline personality disorder (BPD) to date, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 cases and 107,750 controls (all participants of European ancestry). We identified 11 independent associated genomic loci, and nine risk genes in the gene-based analysis. We observed a single-nucleotide polymorphism (SNP) heritability of 17.

Design, Synthesis, and Electrical Performance of Three-Dimensional Hydrogen-Bonded Imidazole-Octamolybdenum-Oxo Cluster Supramolecular Materials.

Polyoxometalate (POM)-type supramolecular materials have unique structures and hold immense potential for development in the fields of biomedicine, information storage, and electrocatalysis. In this study, (NH) [AlMoOH]·7HO was employed as a polyacid anion template, pentacyclic imidazole molecules served as organic ligands, and the moderate-temperature hydrothermal and natural evaporation methods were used in combination for the design and synthesis of two octamolybdenum-oxo cluster (homopolyacids containing molybdenum-oxygen structures as the main small-molecular structures)-based organic-inorganic hybrid compounds, [(CNH)(CNH)][(-MoOH)] () and {Zn(CNH)}{[(-MoO)(CNH)]}·2HO (). Structural and property characterization revealed that both compounds crystallized in the -1 space group with relatively stable three-dimensional structures under the action of hydrogen bonding.

MCC950 Alleviates Fat Embolism-Induced Acute Respiratory Distress Syndrome Through Dual Modulation of NLRP3 Inflammasome and ERK Pathways.

Fat embolism is a critical medical emergency often resulting from long bone fractures or amputations, leading to acute respiratory distress syndrome (ARDS). The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, a key regulator of innate immunity, is activated by reactive oxygen species and tissue damage, contributing to inflammatory responses. This study examines the role of NLRP3 in fat embolism-induced ARDS and evaluates the therapeutic potential of MCC950, a selective NLRP3 antagonist.

Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.

Background: Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.

Regional crowd flow estimation from aerial view.

In recent years, crowd analysis has been widely studied due to its realistic applications in many areas. In this paper, we pose a novel challenge for monitoring large-scale crowd scenes from an aerial view via estimating specific crowd flow for each partitioned region. However, existing methods are difficult to estimate the specific crowd flow for each region flexibly, simply, and accurately, especially lacking clear crowd appearance features from a top-down view.

Integrated single-cell and bulk RNA sequencing reveals prognostic and immunotherapy-associated myofibroblastic cancer-associated fibroblast subtypes in head and neck squamous cell carcinoma.

Background: Cancer-associated fibroblasts (CAFs) are involved in some critical aspects of the pathogenesis of head and neck squamous cell carcinoma (HNSCC), including the formation of a tumor-permissive extracellular matrix (ECM) structure, angiogenesis, and the immune and metabolic reprogramming of the tumor microenvironment (TME). This study aimed to examine the plasticity and metabolic heterogeneity of CAFs in HNSCC patients before and after immunotherapy.

Methods: An integrated single-cell and bulk RNA sequencing (RNA-seq) analysis based on data from the GSE195832, GSE65868, and The Cancer Genome Atlas (TCGA)-HNSCC datasets was conducted.

Develop intelligent waste bin prototype based on fusion feature recognition of sounds and RGB images.

Sorting municipal solid waste (MSW) at the source is a critical first step toward achieving a circular economy. Previous research has primarily focused on vision-based intelligent algorithms for MSW classification using red-green-blue (RGB) images. Some studies have also explored sound-based classification; however, only a few studies have employed multimodal deep learning methods (MDLMs) that integrate both image and sound data for MSW identification.

Twenty-Four-Month Outcomes of Heparin-Bonded Covered Stents and Drug-Coated Balloon Angioplasty in Femoropopliteal Artery Occlusion.

Background: The clinical outcomes of comparing covered stents (CSs) and drug-coated balloons (DCBs) angioplasty in femoropopliteal artery occlusion remain unknown. This study aimed to evaluate the midterm efficacy of CS and DCB procedures in patients with FPO.

Methods: All 194 patients were divided into CS (94 patients) and DCB (100 patients) groups in this multicenter retrospective study.

Exploring Ototoxicity Associated with Capmatinib: Insights from a Real-World Data Analysis of the FDA Adverse Event Reporting System (FAERS) Database.

Background: Capmatinib was approved by the US Food and Drug Administration (FDA) in 2020 for the treatment of non-small cell lung cancer with MET exon 14 mutation (METex14). Real-world studies on the safety of Capmatinib are still lacking. The aim of this study was to explore the significant adverse drug reactions (ADRs) associated with Capmatinib through the FDA Adverse Event Reporting System (FAERS) database.

Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis.

The primary cilium plays a crucial function in sensing and transmitting extracellular signals into cells. The initiation of ciliogenesis hinges on the recruitment of Tau tubulin kinase 2 (TTBK2) to the distal appendages (DAs) of centrioles through CEP164. However, the detailed mechanism underlying the CEP164/TTBK2 interaction at DAs during ciliogenesis remains incompletely understood.

Global research landscape on active surveillance for papillary thyroid microcarcinoma: a bibliometric analysis.

Background: It has been proven that the active surveillance (AS) is safe and feasible for low-risk papillary thyroid microcarcinomas (PTMC). There has been no bibliometric assessment of the scientific advancements in this field. We conducted this study to determine the characteristics and trends of published research on AS for PTMC.

Transforming the management of radiotherapy-induced hypothyroidism in nasopharyngeal carcinoma through an Innovative individualized radiation dosage model: A multicenter retrospective analysis.

Purpose: Current guidelines for thyroid radiation dose prescription lack uniformity and fail to consider the unique characteristics of individual patients. This study aimed to develop an individualized thyroid dosing regimen to enhance thyroid protection during radiotherapy.

Methods And Materials: In this study, we enrolled 621 patients with nasopharyngeal carcinoma (NPC) across four distinct cancer centers, stratifying the data into a training cohort and two external validation cohorts.

Treatment outcomes in nasopharyngeal carcinoma patients with parotid lymph node metastasis: An 11-year experience at a tertiary cancer center.

Parotid lymph node (PLN) metastasis in nasopharyngeal carcinoma (NPC) is rare, with limited data guiding its management and prognosis. We retrospectively analyzed 6924 non-metastatic NPC patients at our tertiary cancer center, identifying 126 patients with PLN metastasis confirmed by fine-needle aspiration cytology (FNAC) and magnetic resonance imaging (MRI). Survival outcomes and prognostic factors were assessed using Kaplan-Meier estimates, log-rank tests, propensity score matching (PSM), and Cox regression.

A bibliometric analysis of nasopharyngeal carcinoma radiomics: trends and insights.

Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by distinct geographic and pathological features. Enhancing diagnostic accuracy and timeliness in NPC is crucial for clinical implications. Radiomics has demonstrated significant potential in the clinical management of NPC.

SympCoughNet: symptom assisted audio-based COVID-19 detection.

COVID-19 remains a significant global public health challenge. While nucleic acid tests, antigen tests, and CT imaging provide high accuracy, they face inefficiencies and limited accessibility, making rapid and convenient testing difficult. Recent studies have explored COVID-19 detection using acoustic health signals, such as cough and breathing sounds.

Identification of glucocorticoid-related genes in systemic lupus erythematosus using bioinformatics analysis and machine learning.

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that has significant impacts on patients' quality of life and poses a substantial economic burden on society.

Objective: This study aimed to elucidate the molecular mechanisms underlying SLE by analyzing glucocorticoid-related genes (GRGs) expression profiles.

Methods: We examined the expression profiles of GRGs in SLE and performed consensus clustering analysis to identify stable patient clusters.

A new sesterterpenoid with -glucuronidase inhibitory activity from the -colonising fungus ZJUTE2.

A new sesterterpenoid versicolorin A () and five known compounds - were isolated from a -colonising fungus ZJUTE2 cultured on soybean meal. The planar structure of was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of was established by NOESY experiment, quantum chemical calculation of C NMR combined with DP4+ probability analysis, and comparison of the optical rotations.

Utilization of 18F-FDG Standardized Uptake Value and Metabolic Tumor Volume to Predict Local Failure in Nasopharyngeal Carcinoma.

Introduction: The aim was to evaluate the prognostic values of pretreatment 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) parameters for predicting local failure in nasopharyngeal carcinoma (NPC) patients in the intensity-modulated radiotherapy (IMRT) era.

Methods: Retrospective analysis was performed on 759 patients with NPC who underwent pretreatment 18F-FDG PET. The optimal cutoff values for maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were determined by receiver operating characteristic curve analysis.

Post-Marketing Safety of Temozolomide: A Pharmacovigilance Study Based on the Food and Drug Administration Adverse Event Reporting System.

Introduction: Temozolomide (TMZ) is a widely used chemotherapy agent for the treatment of malignant gliomas and other brain tumors. Despite its established therapeutic benefits, there is an ongoing need to understand better its safety profile, particularly in real-world clinical settings. This study aimed to identify critical adverse drug reactions (ADRs) associated with TMZ by utilizing the FDA Adverse Event Reporting System (FAERS) database, thereby providing valuable safety insights for clinical practice.

Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs.

Antidepressants exhibit a considerable variation in efficacy, and increasing evidence suggests that individual genetics contribute to antidepressant treatment response. Here, we combined data on antidepressant non-response measured using rating scales for depressive symptoms, questionnaires of treatment effect, and data from electronic health records, to increase statistical power to detect genomic loci associated with non-response to antidepressants in a total sample of 135,471 individuals prescribed antidepressants (25,255 non-responders and 110,216 responders). We performed genome-wide association meta-analyses, genetic correlation analyses, leave-one-out polygenic prediction, and bioinformatics analyses for genetically informed drug prioritization.

Exploring a specific type of tissue-resident natural killer cell involved in the anti-tumor and immunotherapy response in human papillomavirus-positive head and neck squamous cell carcinoma using scRNA-seq.

Background: Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is an increasingly common malignancy. We aimed to explore the immune heterogeneity of natural killer (NK) cells in HPV-positive HNSCC.

Methods: Single-cell RNA-sequencing (scRNA-seq) and bulk RNA-sequencing datasets of HPV-positive HNSCC data were obtained from the Gene Expression Omnibus (GEO) database.

Sequential Immune Acquisition of Monoclonal Antibodies Enhances Phagocytosis of by Recognizing ATP Synthase.

: The aim of this study was to prepare monoclonal antibodies (mAbs) that broadly target and protect against infection by multi-drug-resistant (MDR) from different sources. : mAb 8E6 and mAb 1B5 were prepared by sequentially immunizing mice with a sublethal inoculation of three heterogeneous serotypes of pan-drug-resistant (PDR) , ST-208, ST-195, and ST-229. : The cross-recognition of heterogeneous bacteria (n = 13) by two mAbs and potential targets was verified, and the in vitro antibacterial efficacy of mAbs was assessed.