Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Background: The current classification system of progressive collapsing foot deformity (PCFD) is comprised of 5 possible classes. PCFD is understood to be a complex, three-dimensional deformity occurring in many regions along the foot and ankle. The question remains whether a deformity in one area impacts other areas. The objective of this study is to assess how each one of the classes is influenced by other classes by evaluating each associated angular measurement. We hypothesized that positive and linear correlations would occur for each class with at least one other class and that this influence would be high.

Methods: We retrospectively assessed weight bearing CT (WBCT) measurements of 32 feet with PCFD diagnosis. The classes and their associated radiographic measurements were defined as follows: class A (hindfoot valgus) measured by the hindfoot moment arm (HMA), class B (midfoot abduction) measured by the talonavicular coverage angle (TNCA), class C (medial column instability) measured by Meary's angle, class D (peritalar sub-luxation) measured by the medial facet uncoverage (MFU), and class E (ankle valgus) measured using the talar tilt angle (TTA). Multivariate analyses were completed comparing each class measurement to the other classes. A p-value <0.05 was considered significant.

Results: Class A showed substantial positive correlation with class C (ρ=0.71; R=0.576; p=0.001). Class B was substantially correlated with class D (ρ=0.74; R=0.613; p=0.001). Class C showed a substantial positive correlation with class A (ρ=0.71; R=0.576; p=0.001) and class D (ρ=0.75; R=0.559; p=0.001). Class D showed substantial positive correlation with class B and class C (ρ=0.74; R=0.613; p=0.001), (ρ=0.75; R=0.559; p=0.001) respectively. Class E did not show correlation with class B, C or D (ρ=0.24; R=0.074; p=0.059), (ρ=0.17; R=0.071; p=0.179), and (ρ=0.22; R=0.022; p=0.082) respectively.

Conclusion: This study was able to find relations between components of PCFD deformity with exception of ankle valgus (Class E). Measurements associated with each class were influenced by others, and in some instances with pronounced strength. The presented data may support the notion that PCFD is a three-dimensional complex deformity and suggests a possible relation among its ostensibly independent features. .

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10777689PMC

Publication Analysis

Top Keywords

progressive collapsing
8
collapsing foot
8
class
8
valgus measured
8
classes
6
measured
5
deformities influencing
4
influencing classes
4
classes progressive
4
foot background
4

Similar Publications

Ethnopharmacological Relevance: The high mortality rate associated with severe influenza partly results from delayed initiation of antiviral therapy and subsequent cytokine storms. Jiuwei Qianghuo Decoction combined with Zhuye Shigao Decoction (JZF) has been clinically prescribed to prevent the progression to a more severe illness in influenza treatment. However, the precise mode of action and active components have not yet been elucidated.

View Article and Find Full Text PDF

Targeting protein misfolding in Alzheimer's disease: The emerging role of molecular chaperones.

Biomed Pharmacother

September 2025

Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma 378, Ethiopia; Division of Research & Development, Lovely Professional University, Phagwara 144411, India. Electronic address:

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline and the accumulation of misfolded proteins, including amyloid-beta and hyperphosphorylated tau, which impair neuronal function and promote cell death. These misfolded proteins disrupt proteostasis by forming toxic aggregates that exacerbate disease progression. Molecular chaperones, such as heat shock proteins, actively maintain protein homeostasis by assisting in proper folding, preventing aggregation, and promoting the clearance of misfolded proteins.

View Article and Find Full Text PDF

A pediatric-onset case of chronic kidney disease caused by a novel sporadic variant and literature review.

Turk J Pediatr

September 2025

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: The α-actinin-4 (ACTN4) gene encodes an actin-binding protein, which plays a crucial role in maintaining the structure and function of podocytes. Previous studies have confirmed that ACTN4 mutations can lead to focal segmental glomerulosclerosis-1 (FSGS1), a rare disease primarily manifesting in adolescence or adulthood, characterized by mild to moderate proteinuria, with some cases progressing slowly to end-stage renal disease.

Case Presentation: We report a 12.

View Article and Find Full Text PDF

Background: Chagas heart disease (ChD) is a significant public health concern in Latin America, contributing to a high incidence of sudden cardiac death (SCD). Despite advances in heart failure treatment, management of Chagas cardiomyopathy has not progressed accordingly. While ICDs are effective for primary and secondary prevention in other conditions, patients with ChD often experience more frequent episodes of ventricular tachycardia, and ICD use may provide a negative impact and increase mortality.

View Article and Find Full Text PDF

Long-Term Functional Outcomes and Modes of Failure of Fresh Frozen Hemicondylar Allografts: A Retrospective Cohort Study.

J Surg Oncol

September 2025

Orthopedic Oncology Service, Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Hemicondylar fresh frozen allografts address partial knee defects while preserving native anatomy and bone stock. This study evaluated long-term survival, failure modes, and functional outcomes following hemicondylar reconstruction.

Methods: We conducted a retrospective analysis of hemicondylar fresh frozen allograft reconstructions.

View Article and Find Full Text PDF