Insights from the first 820 patients from the Brazilian Multicenter Registry of Hereditary Angioedema: the key role of genetic testing and targeted therapies.

Background: Hereditary angioedema (HAE) is a rare autosomal dominant disorder with a prevalence of 1:50,000 individuals. Delayed diagnosis and deaths from asphyxia still occur.

Objective: To identify knowledge and management gaps regarding clinical, genetic, and therapeutic aspects of HAE in Brazil, aiming to improve patient care and outcomes.

Prevention of Neonatal Infections in Newborns Using Kangaroo Care Method: A Systematic Review and Meta-analysis.

This study aimed to investigate the impact of KC on the prevention of neonatal infections. Initial article screening by title and abstract was performed independently by paired reviewers utilizing the RAYYAN tool, with conflicts resolved by a senior researcher. Statistical analysis was conducted using the Review Manager and R version 4.

Impact of vehicular technological improvements on emissions and air quality across Brazil.

Controlling vehicular emissions is a critical priority, particularly in developing countries like Brazil, where the vehicular fleet has expanded significantly. Although Brazil's Program to Control Vehicular Emissions has reduced certain air pollutants by mandating technological advancements in new vehicles, it did not consider the substantial increase in vehicle numbers and density across the country. To date, no comprehensive national-scale evaluation has been conducted to assess the program's effectiveness in Brazil.

The impact of hormonal intrauterine device use on health-related quality of life in women with a history of venous thromboembolism: a systematic review.

Objective: To systematically review the available evidence on changes in health-related quality of life (HRQoL) associated with the levonorgestrel-releasing intrauterine system (LNG-IUS) for contraception or menstrual bleeding management in women with a history of venous thromboembolism (VTE), regardless of anticoagulant use.

Methods: This systematic review was conducted following Cochrane Collaboration guidelines and the PRISMA statement. A comprehensive search was carried out in PubMed, Embase, Cochrane Central, Scopus, Web of Science, and the Virtual Health Library (VHL), without language or date restrictions.

Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism.

Dietary patterns may increase cardiometabolic risk, especially in genetically predisposed individuals. Thus, the present study evaluated the association between dietary patterns and cardiometabolic risk factors in children with fat mass and obesity associated (FTO) gene polymorphism. A cross-sectional survey of 258 children aged 4-7 years.

Survival of dental implants in irradiated head and neck cancer patients compared to non-irradiated patients: An umbrella review.

Background: There is an increasing demand for oral rehabilitation in patients undergoing irradiation for head and neck cancer treatment. Although radiotherapy appears to adversely affect implanted oral rehabilitation, the evidence provided by previous systematic reviews in the field remains controversial. Thus, this umbrella review aimed to evaluate the survival of dental implants installed before and/or after radiotherapy in patients with head and neck cancer compared to those not irradiated.

Subjective mental fatigue ratings are not associated with basketball game-related statistics during official semiprofessional male games.

Introduction: Mental fatigue (MF) has been shown to affect several domains of team sports performance, including physical, technical, and perceptual-cognitive aspects. This study examined whether subjective ratings of mental fatigue (MF) are associated with technical-tactical performance in adult male basketball official games.

Methods: Fourteen semiprofessional players (age: 22.

Rosacea and Migraine: A Systematic Review and Meta-Analysis Update.

Background: The association between rosacea and migraine is well-recognized, but the underlying mechanisms remain unclear. Emerging evidence suggests potential benefits of anti-migraine treatments for rosacea, highlighting the need for updated insights. This systematic review and meta-analysis assessed migraine prevalence in rosacea patients, compared it with non-rosacea populations, and explored influencing factors.

Comparative Efficacy and Safety of Intravenous Cangrelor versus Intravenous Glycoprotein IIb/IIIa Inhibitors after Mechanical Thrombectomy for Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Background: Intravenous cangrelor and Glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa I) are current options in antiplatelet therapy during neurointerventional procedures, potentially enhancing reperfusion and preventing reocclusion. In specific conditions, these antiplatelet agents are employed as adjuvant to mechanical thrombectomy (MT), a procedure that is crucial for patients with acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, direct comparisons of these drugs in this context remain limited.

Effect of peri-operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta-analysis.

Introduction: Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta-analysis of randomised controlled trials assessing the effect of pharmacological interventions on the incidence of postoperative delirium.

Physicochemical and Antioxidant Properties of Anacardium humile A. St.-Hil, an Underexploited Fruit from the Brazilian Cerrado.

Anacardium humile, popularly known as cajuzinho-do-cerrado or cajuí, is a native fruit from the Brazilian Cerrado biome that shares similarities with Anacardium occidentale. This study aimed to characterize the nutritional elements, bioactive compounds, and antioxidant activity of yellow- and red-peeled A. humile pseudofruits grown in Bonito de Minas, Minas Gerais, Brazil.

Replacing sedentary behavior with physical activity reduces symptoms of anxiety and depression: a study with young adults.

Background: Physical activity (PA) and sedentary behavior (SB) are movement behaviors that have been associated with mental health. Evidence suggests that replacing SB with PA may influence mental disorders. This study aimed to evaluate the effects of replacing time spent in SB with moderate-intensity PA (MPA) and vigorous-intensity (VPA) on the symptoms of anxiety and depression among college students.

Evaluability assessment of social protection services for people experiencing homelessness in Brazil.

This is an Evaluability Assessment (EA) of the Specialized Care for Vulnerable Populations (SEAS) and Specialized Reference Centers for People Experiencing Homelessness (Centro POP) in Belo Horizonte, Brazil. These are social protection services for people in vulnerable situations who use the streets for housing and/or survival. The Thurston and Ramaliu model was employed with the construction of theoretical and logical models and SWOT matrix, using the analysis of legal frameworks, technical documents, on-site visits, and discussion groups with local managers.

Historical and spatial analysis of the water quality in a tropical eutrophic system: a case study of remediation strategies in Pampulha reservoir, Brazil.

There are several water treatments carried out in reservoirs worldwide, and evaluating their effect on water quality is essential for improving techniques. Pampulha reservoir, an urban eutrophic reservoir, is strongly impacted by domestic and industrial sewage. This study aimed to investigate its water quality using a spatial and temporal approach, discussing the effects of existing pollution control techniques in this system, such as Phoslock, Enzilimp, and waste retaining curtain.

Design of a Low-Cost Gateway with LoRa Technology Serving Multiple Devices.

The growing demand for scalability and efficiency in Low Power Wide Area Networks (LPWANs) presents significant challenges, particularly due to the increasing number of connected devices and the inherent limitations of the ALOHA protocol, which is widely used in LoRaWAN networks. In this context, this work proposes the design and development of a low-cost dual-channel gateway tailored for Internet of Things (IoT) networks based on LoRa technology. To address the aforementioned challenges, this study explores approaches such as channel activity detection (CAD) and dynamic channel allocation, aiming to reduce collisions and optimize spectrum utilization.

Evaluation of the Cytotoxic Activity of Nanostructured Lipid Carrier Systems for Fatty Acid Amides and Silk Fibroins in Breast Cancer Cell Lines.

Breast cancer, a highly prevalent malignancy among women, continues to pose a significant global health challenge, as conventional therapies are often limited by adverse effects. This study developed and evaluated nanostructured lipid carriers (NLCs) encapsulating fatty acid amides (FAAs) semi-synthesized from andiroba oil and combined with silk fibroin (SF) as a novel therapeutic strategy. Methods: FAAs were synthesized via direct amidation and characterized by GC-MS, FT-IR, and C NMR.

Neurodevelopmental Outcomes Associated with Early-Life Exposure to Heavy Metals: A Systematic Review.

Introduction: Globally, approximately 53 million children under the age of five live with some form of developmental disability. Exposure to heavy metals has been identified in the literature as a contributing factor in the etiology of neurodevelopmental disorders, however it usually is understudied. Even at low concentrations, these toxicants pose a risk to neurodevelopment, when affecting children early as in the prenatal period.

Quinolone Resistance and Zoonotic Potential of from Domestic Animals in Brazil.

Background: is an emerging zoonotic pathogen capable of cau-sing diphtheria-like infections in humans.

Objectives: we report, for the first time in Brazil, the detection and phenotypic/genomic characterization of three atoxigenic ST-339 strains isolated from domestic animals, including one with a ciprofloxacin resistance profile linked to double GyrA mutations (S89L, D93G).

Methods: species identification was performed by MALDI-TOF MS, followed by in vitro antimicrobial susceptibility testing, whole-genome sequencing, and bioinformatic analyses to predict virulence determinants, antimicrobial resistance genes, CRISPR-Cas systems, mobile genetic elements, and in silico structural analysis as well as phylogenetic reconstruction.

Risk Factors and Prevalence of spp. in Poultry Carcasses in Slaughterhouses Under Official Veterinary Inspection Service in Brazil.

Because of the relevance of spp. in poultry, in 2016, the Brazilian Ministry of Agriculture, Livestock, and Supply updated its regulation for the control and monitoring of in the poultry meat production chain. We herein present the results of the official monitoring of sampling cycles of carcasses performed by the Brazilian official veterinary inspection service (SIF) and the Center for Epidemiology, Statistics, and Public Health of the Veterinary School of the Federal University of Minas Gerais.

Anaerobic digestion of food waste under non-conventional operating conditions: enhancing process stability while reducing energy and chemical inputs.

Decentralized anaerobic treatment presents a sustainable alternative for managing the substantial generation of food waste. However, the associated high costs may render this option less feasible for small- to medium-scale systems. To explore a novel strategy for cost reduction in anaerobic digestion systems used for food waste treatment, this study applied organic loading rates (OLR) ranged from 0.

Efficacy and Safety of Flow Diversion for Distal Anterior Cerebral Aneurysms: A Systematic Review and Proportional Meta-Analysis.

Background: Flow diverters (FDs) are increasingly used off-label for the treatment of distal anterior cerebral artery aneurysms (DACAAs), located at or beyond the A2 segment of the anterior cerebral artery (ACA). However, data on safety and efficacy remain limited.

Purpose: To evaluate the safety and efficacy of FDs for the treatment of DACAAs through a systematic review and meta-analysis.