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Article Abstract
Fengycin has great potential for applications in biological control because of its biosafety and degradability. In this study, the addition of exogenous precursors increased fengycin production by . was engineered to produce high levels of precursors (Thr, Pro, Val, and Ile) to promote the biosynthesis of fengycin. Furthermore, recombinant . and providing amino acid and fatty acid precursors were co-cultured to improve fengycin production by in a three-strain artificial consortium, in which fengycin production was 2100 mg·L. In addition, fengycin production by the consortium in a 5 L bioreactor reached 3290 mg·L. Fengycin had a significant antifungal effect on , which illustrates its potential as a food preservative. Taken together, this work provides a new strategy for improving fengycin production by a microbial consortium and metabolic engineering.
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