Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Wisconsin experienced overlapping and accelerating epidemics of opioid use and COVID-19 after March 2020. We hypothesized that Wisconsin neonatal abstinence syndrome rates increased after March 2020 alongside other markers of opioid burden.
Methods: Retrospective cohort analysis examined deidentified Wisconsin census, birth certificate, death certificate, hospital discharge, Prescription Drug Monitoring Program, emergency medical service run, and COVID-19 diagnosis records spanning January 1, 2019, through December 31, 2021. January 2019 through March 2020 was considered before the onset of COVID-19 (pre); April 2020 through December 2021 was considered post-onset of COVID-19 (post). Wisconsin Department of Health Services guidelines defined 5 Wisconsin regions. Rates pre- to post-onset were compared with values < 0.05 considered statistically significant.
Results: Of 1362 patients, 83.3% completed a COVID-19 vaccination series. Younger patients had increased odds of not completing a COVID-19 vaccination series (mean [SD] 46.7 [14.7] vs 54.3 [15.8]; OR 1.03; 95% CI, 1.02-1.04; < 0.001). Those who identified as non-White (1.88; 95% CI, 1.16-3.04; P = 0.010) or current smoker (1.85, 95% CI, 1.85-2.79; P = 0.004) had increased odds of not completing a COVID-19 vaccination series. Those who resided in rural ZIP codes (1.81; 95% CI, 1.35-2.43; < 0.001), had not received a 2019-2020 influenza vaccine (5.13; 95% CI, 3.79-6.96; < 0.001), or had lower comorbidity scores (2.95; 95% CI, 1.98-4.41; < 0.001) had higher odds of not completing a COVID-19 vaccination series.
Conclusions: Opioid-associated morbidity and mortality increased in Wisconsin during the study period, including among females age 15 to 44 years. Despite increased opioid burden, neonatal abstinence syndrome incidence decreased in the Southeastern Region. Ongoing neonatal abstinence syndrome and opioid analysis may benefit from region-based contextualization.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Roman Catholic Religious Affiliation and Reactions to the Initial Stage of the COVID-19 Pandemic in Poland.
J Relig Health
September 2025
Center for Climate Action and Social Transformations (4CAST) Institute of Psychology, SWPS University, Warsaw, Poland.
The present study examined responses to COVID-19 at the beginning of the pandemic, April 2020, among a representative sample of 880 Poles. Participants described their religious beliefs, their emotional reactions to the pandemic, the changes they had made in their behavior since the onset of the pandemic, and their political orientation (left-right). Roman Catholics felt more threatened by the pandemic than non-believers, and Catholics reacted more strongly to the pandemic than non-believers in terms of feeling scared, paralyzed by fear, panicked, fearful, sad, woebegone, and lost, whereas there were no such differences on other emotional reactions.
View Article and Find Full Text PDFRemote and digital services in UK general practice 2021-2023: the Remote by Default 2 longitudinal qualitative study synopsis.
Health Soc Care Deliv Res
September 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Background: Remote services (in which the patient and staff member are not physically colocated) and digital services (in which a patient encounter is digitally mediated in some way) were introduced extensively when the COVID-19 pandemic began in 2020. We undertook a longitudinal qualitative study of the introduction, embedding, evolution and abandonment of remote and digital innovations in United Kingdom general practice. This synoptic paper summarises study design, methods, key findings, outputs and impacts to date.
View Article and Find Full Text PDFPerformance of non-invasive prenatal testing in vanishing-twin and multiple pregnancies: results of TRIDENT-2 study.
Ultrasound Obstet Gynecol
September 2025
Department of Clinical Genetics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
Objective: To evaluate the performance of non-invasive prenatal testing (NIPT) in vanishing-twin and multiple pregnancies.
Methods: This study was conducted as part of the TRIDENT-2 study, in which NIPT was offered as a first-tier screening test to women with a multiple pregnancy or vanishing-twin pregnancy between 1 June 2020 and 31 March 2023 in The Netherlands. Abnormal NIPT results were investigated by follow-up invasive prenatal testing and/or postnatal genetic testing.
Trends in Use of Direct-Acting Antivirals for Treatment of Hepatitis C Virus Infection in Australia 2016-2024.
J Viral Hepat
October 2025
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Direct-acting antivirals (DAAs) have transformed hepatitis C virus (HCV) treatment in Australia since their inclusion on the Pharmaceutical Benefits Scheme (PBS) in 2016. Treatment has shifted from genotype-specific to pan-genotypic regimens, with glecaprevir/pibrentasvir and sofosbuvir/velpatasvir now recommended in clinical guidelines. This study examined trends in DAA dispensing in light of evolving treatment regimens.
View Article and Find Full Text PDFMolecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.
J Am Heart Assoc
September 2025
Department of Radiology, Beijing Friendship Hospital Capital Medical University Beijing China.
Background: High blood pressure (BP) is a known risk factor for cognitive decline and dementia, but the underlying mechanisms are largely unknown. We investigated the associations of cumulative BP exposure with hippocampal subfield volume and cognitive function and determined whether hippocampal subfield atrophy mediates the association between cumulative BP exposure and cognitive decline.
Methods: Between December 2020 and March 2023, participants were prospectively included from the Kailuan study.