Publications by authors named "C J Bax"
Performance of non-invasive prenatal testing in vanishing-twin and multiple pregnancies: results of TRIDENT-2 study.
Ultrasound Obstet Gynecol
September 2025
Objective: To evaluate the performance of non-invasive prenatal testing (NIPT) in vanishing-twin and multiple pregnancies.
Methods: This study was conducted as part of the TRIDENT-2 study, in which NIPT was offered as a first-tier screening test to women with a multiple pregnancy or vanishing-twin pregnancy between 1 June 2020 and 31 March 2023 in The Netherlands. Abnormal NIPT results were investigated by follow-up invasive prenatal testing and/or postnatal genetic testing.
Objective: To examine the experiences, perspectives, and impact on daily work of maternity care providers regarding the updated Dutch national guideline on the management of late-term pregnancies.
Design And Setting: This was a cross-sectional survey for maternity care providers in the Netherlands in 2024.
Methods: An online questionnaire was developed, improved on the basis of four semi-structured interviews, piloted, and distributed to primary care and hospital-based midwives, residents, and obstetricians.
Objectives: Noninvasive prenatal testing (NIPT) to screen for fetal aneuploidies by analysing cell-free DNA in maternal plasma is available to pregnant women worldwide. In the future, the scope of NIPT could potentially be expanded to the prediction of adverse pregnancy outcomes. The objective of this study was to assess and compare the preferences of pregnant women and obstetric healthcare professionals on this new test purpose of NIPT.
View Article and Find Full Text PDFArticle Synopsis
- Early risk assessment in pregnancy can help prevent serious issues like preeclampsia and gestational diabetes by identifying at-risk mothers early on.
- This study reviewed 77 articles on first-trimester prediction models focused on maternal characteristics, excluding those using biochemical or ultrasound data, and found varied effectiveness in predicting outcomes.
- Many of the models showed a high risk of bias, and there’s a need for better validation processes, indicating that while tools exist, their reliability and clinical use must be improved.
Objective: To assess the added value of fetal fraction of cell-free DNA in the maternal circulation in the prediction of adverse pregnancy outcomes.
Design: Retrospective cohort study.
Setting: Nationwide implementation study on non-invasive prenatal testing (NIPT; TRIDENT-2 study).