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Article Abstract
Elevated detection rates of the gene in animals have been reported as a result of antibiotic misuse in clinics. To investigate the horizontal transfer mechanism of and its associated mobile genetic elements (MGEs), we isolated 318 nonrepetitive strains of () from bovine samples in Xinjiang and Gansu provinces, China. All strains were screened for the gene using PCR. The complete genomic data were sequenced using the PacBio triplet sequencing platform and corrected using the Illumina data platform. The genetic environment of the plasmids carrying the resistance gene was mapped using the software Easyfig2.2.3 for comparison. The results showed that all -positive strains were resistant to multiple antibiotics. Five strains of carry the gene, which is adjacent to other resistance genes and is located on the IncHI2-type plasmid. Four of the five -harbor strains carried translocatable units (TUs). All the donor bacteria carrying the genes could transfer horizontally to the recipient ( J53 Azr). This study demonstrates that the transmission of is localized on IS-flanked composite transposons. The cotransmission and prevalence of with other MDR resistance genes on epidemic plasmids require enhanced monitoring and control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673294 | PMC |
| http://dx.doi.org/10.3390/microorganisms11112795 | DOI Listing |
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