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http://dx.doi.org/10.1186/s11689-023-09499-5 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Stomatology, Taikang Tongji (Wuhan) Hospital, Wuhan, Hubei Province, P.R. China.
Previous studies have suggested potential associations between some dietary factors and oral mucosal lesions (OMLs), however, existing research could be biased due to limited sample size and unaccounted confounding factors. This study aimed to explore the causal relationships between 13 common dietary factors and 3 OMLs using 2-sample Mendelian randomization (MR) analysis. Data for the MR analysis were extracted from publicly available genome-wide association study statistics.
View Article and Find Full Text PDFZhonghua Nan Ke Xue
August 2025
Department of Urology, Northern Jiangsu People's Hospital Afflicted to Yangzhou University Yangzhou, Yangzhou, Jiangsu 225001, China.
Objective: To evaluate the association between erectile dysfunction (ED) and myocardial infarction (MI) using two sample Mendelian randomization.
Methods: A Mendelian randomization study was conducted using comprehensive data on ED and MI from extensive genome-wide association data. Using inverse variance weighted analysis for causal relationships, and correct for confounding factors using multivariate Mendelian randomization, the potential mediating effects were evaluated as well.
J Asthma
September 2025
Institute of Tropical Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Background: Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches.
Methods: Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites.
Int J Chron Obstruct Pulmon Dis
September 2025
Department of Cadre Respiratory, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210002, People's Republic of China.
Background: Previous Mendelian randomization (MR) studies investigating the causal relationship between lipid traits and chronic obstructive pulmonary disease (COPD) have primarily focused on individuals of European (EUR) ancestry, limiting the generalizability of findings. This study aimed to address this limitation.
Methods: Summary-level data for individuals of East Asian (EAS), African (AFR), and Hispanic (HIS) ancestry were obtained from large-scale genetic databases.
Medicine (Baltimore)
August 2025
Department of Otorhinolaryngology, Pengzhou Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.
An increasing body of research indicates an association between lipid-lowering medications and sensorineural hearing loss (SNHL), although there is still controversy. Therefore, the aim of this study is to investigate the genetic correlation between different lipid-lowering therapeutic gene targets and SNHL. The genetic association between lipids, lipid-lowering drug target genes, and SNHL was analyzed using a 2-sample Mendelian randomization approach.
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