Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Hydrazine (NH) and hypochlorite (ClO) are extremely harmful to the public health, so it is vitally necessary to detect them in living system. Herein, we developed a new phenthiazine-thiobarbituric acid based dual-analyte responsive fluorescent sensor PT for visually distinguishing and detecting NH and ClO. PT underwent NH/ClO-induced CC breakage, achieving olive-drab/brilliant green fluorescence lighting-up response towards NH/ClO with superb specifity, ultra-sensitivity (detection limit: 15.4 nM for NH, 13.7 nM for ClO), and ultra-fast response (NH: <15 s, ClO: <20 s). The mechanisms for sensing NH and ClO were investigated with support of spectral measurements and DFT investigation. Sensor based paper-strip/silica-gel device was developed for in-field supervision and on-site monitoring of gaseous and aqueous NH and ClO solution. In addition, the PT was also applied for quantitatively detecting NH and ClO in soil, food, plants and bio-fluids. Moreover, PT was utilized to visualize exogenous NH and ClO in living plants and live-cells, demonstrating this sensor utilized as a powerful tool to detect NH and ClO in biological fields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.aca.2022.340735 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research progress on design strategies of hemicyanine-based fluorescent probes and their applications in environmental and food analysis.
Analyst
September 2025
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, China.
With the increasing emphasis on environmental safety, food inspection, and plant physiological functions, the development of high-performance fluorescent probes capable of highly sensitive, specific, rapid, and visual detection of target analytes has become a focal point in current research. Hemicyanine groups are widely utilized in the design of organic small-molecule fluorophores due to their low cost, structural stability, and ease of chemical modification. Through simple structural adjustments, the photoluminescent properties of hemicyanine-based fluorophores can be significantly enhanced, enabling strong signal output and maintaining stable fluorescence intensity across various solvents and pH conditions-features that make them particularly suitable for complex biological and chemical environments.
View Article and Find Full Text PDFA novel N-alkyhydrazone-based Iridium(III) complex for luminescence imaging of mitochondrial hypochlorous acid in liver injury.
Anal Chim Acta
September 2025
Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanxi, 710072, China. Electronic address:
The production of hypochlorous acid (HClO) is well recognized as a biomarker for liver injury, however, existing HClO bioimaging probes often lack specificity. Inspired by the specific recognition of oxime and hydrazide groups for HClO, we developed a novel N-alkyhydrazone moiety as a recognition unit for HClO. This moiety was integrated into an iridium(III) complex, creating a mitochondria-targeted luminescence probe for HClO that leverages the lipophilicity and cationic characteristics of iridium(III) complexes.
View Article and Find Full Text PDFA dual recognition site-based ratiometric fluorescent probe with reversible mechanochromism and acetochromism for ultra-sensitive hypochlorite detection.
Org Biomol Chem
July 2025
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-14, Tamil Nadu, India.
Existing hypochlorite (ClO) probes often rely on a single recognition site, limiting their sensitivity and versatility. To address this, we designed and synthesized a phenothiazine-benzothiazole hydrazine-based ratiometric chemodosimeter (PBT-1) with dual hypochlorite recognition sites, achieving enhanced detection capabilities with an ultra-low detection limit of 0.026 nM.
View Article and Find Full Text PDFA portable sensing platform using a novel dipyrrolopyrazinedione-based aza-BODIPY dimer for highly efficient detection of hypochlorite and hydrazine.
Spectrochim Acta A Mol Biomol Spectrosc
November 2025
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China. Electronic address:
As widely used chemical reagents in different industrial fields, reactive hydrazine (NH) and hypochlorite (ClO) show significant risks to human health, drink water, and environment. Currently, fluorescence detection of two analytes suffers from slow and minor spectral change, high detection limit and poor selectivity. In this work, by introducing electron deficient 1,4-pyrazine ring enhanced chromophore reaction strategy, a novel dipyrrolopyrazinedione-based aza-BODIPY dimer (PzDP-PPAB) was synthesized for the first time.
View Article and Find Full Text PDFA dual-responsive ratiometric fluorescent probe for the detection of hypochlorite and hydrazine in environmental samples, live cells, and plant tissues.
Anal Methods
April 2025
Molecular Sensor and Supramolecular Chemistry Laboratory, Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah-711103, West Bengal, India.
Hypochlorite (ClO), a potent oxidizer and disinfectant, and hydrazine, a powerful reducing agent, are widely used in daily life and various industries. However, their extensive use comes with significant risks, as they are highly toxic to both the environment and human health. They have been associated with various health issues and even linked to cancer.
View Article and Find Full Text PDF