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Article Abstract
Background: In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions.
Methods: We used an allogeneic murine kidney transplant model in which CD45.2 BALB/c kidneys were transplanted to CD45.1 C57BL/6 recipients.
Results: Donor kidney resident macrophages within the allograft expanded rapidly in the first 3 days. During this period, they were also induced to express a high level of , which, in turn, promoted recipient monocyte graft infiltration, their differentiation to resident macrophages, and subsequent expression of . Enhanced graft infiltration of recipient CCR8 T cells followed, including CD4, CD8, and T cells. Consequently, blocking CCL8-CCR8 or depleting donor kidney resident macrophages significantly inhibits early allograft immune cell infiltration and promotes superior short-term allograft function.
Conclusions: Targeting the CCL8-CCR8 axis is a promising measure to reduce early kidney allograft inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528333 | PMC |
| http://dx.doi.org/10.1681/ASN.2022020139 | DOI Listing |
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