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Article Abstract
Objective: To investigate the effects of oocyte donor and recipient body mass index (BMI) on outcomes of vitrified donor oocyte assisted reproductive technology (ART).
Design: Retrospective cohort study.
Setting: Private fertility center.
Patients: A total of 338 oocyte donors and 932 recipients who underwent 1,651 embryo transfer cycles in 2008-2015.
Interventions: Multivariable log binomial regression models with cluster-weighted generalized estimating equations were used to estimate the adjusted risk ratios.
Main Outcome Measures: Live birth, defined as the delivery of at least one live-born infant, including all embryo transfer cycles. Secondary outcomes included birth weight and gestational length only among singleton live births.
Results: The mean ± SD body mass indexes (BMIs) of donors and recipients were 22.6 ± 2.5 kg/m and 24.6 ± 4.8 kg/m, respectively. There were no significant associations between donor BMI and probability of live birth. Recipients with BMI ≥35 kg/m had a significantly higher probability of live birth compared with normal-weight recipients. Among singleton live births, recipients with BMI <18.5 kg/m had a lower risk whereas women with BMI ≥35 kg/m had a higher risk of delivery in an earlier gestational week compared with normal weight women. Recipients with a BMI ≥35 kg/m also had a higher risk of having a low birth weight infant compared with normal-weight women.
Conclusions: In the setting of vitrified donor oocyte ART, recipient BMI was positively associated with probability of live birth but negatively associated with gestational length and birth weight among singleton births.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244280 | PMC |
| http://dx.doi.org/10.1016/j.xfre.2020.10.006 | DOI Listing |
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