98%
921
2 minutes
20
The evolutionary and genetic origins of the specialized body plan of flatfish are largely unclear. We analyzed the genomes of 11 flatfish species representing 9 of the 14 Pleuronectiforme families and conclude that Pleuronectoidei and Psettodoidei do not form a monophyletic group, suggesting independent origins from different percoid ancestors. Genomic and transcriptomic data indicate that genes related to WNT and retinoic acid pathways, hampered musculature and reduced lipids might have functioned in the evolution of the specialized body plan of Pleuronectoidei. Evolution of Psettodoidei involved similar but not identical genes. Our work provides valuable resources and insights for understanding the genetic origins of the unusual body plan of flatfishes.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110480 | PMC |
http://dx.doi.org/10.1038/s41588-021-00836-9 | DOI Listing |
J Evid Based Med
September 2025
Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (the First People's Hospital of Shunde), Foshan, China.
Aim: The white-coat hypertension (WCH) detection by monitoring the out-of-office blood pressure (BP) consumes resources and time. This study aimed at developing the prediction model based on patients' characteristics obtained from clinical data.
Methods: Individuals who participated in two large hospitals health check-up examination were screened.
PLoS One
September 2025
Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Volumetric modulated arc therapy (VMAT) for lung cancer involves complex multileaf collimator (MLC) motion, which increases sensitivity to interplay effects with tumour motion. Current dynamic conformal arc methods address this issue but may limit the achievable dose distribution optimisation compared with standard VMAT. This study examined the clinical utility of a VMAT technique with monitor unit limits (VMATliMU) to mimic conformal arc delivery and reduce interplay effects while maintaining plan quality.
View Article and Find Full Text PDFCNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFMacromol Rapid Commun
September 2025
School of Materials and Chemistry, Anhui Agricultural University, Hefei, Anhui, China.
At present, flexible sensors are a hot spot in research and experimental development, but the research on flexible sensors that can be used for human motion monitoring still needs to be deepened. In this work, the green material cellulose acetate (CA) was used as the matrix material, the film was made by electrospinning, crushed by a cell grinder and sodium alginate (SA) was added to promote the uniform dispersion of nanofibers in water, and then methyltrimethoxysilane (MTMS) and MXene nanosheet dispersion were added to make it hydrophobic and good conductivity, and the aerogel precursor solution was prepared, and then the CA/SA/MTMS/MXene aerogel with directional holes was prepared by directional freeze-drying. As a flexible sensor material, it can be used for human wear, monitoring the electrical signals generated by the movement of human joints and other parts, and can still maintain a current of about 0.
View Article and Find Full Text PDFCureus
August 2025
Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, JPN.
Background A cold-sensitivity constitution (CSC), termed "Hiesho" in Japanese, is a common condition among young women that impairs quality of life through reduced peripheral circulation and autonomic imbalance. In our previous study, we reported that cold intolerance is associated with an imbalance in autonomic nervous function, as evaluated by heart rate variability (HRV). Conversely, footbathing increases parasympathetic nervous activity (PNA) and increases both peripheral blood flow and epidermal temperature.
View Article and Find Full Text PDF