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Article Abstract
Materials And Methods: Bark extracts of these plants (1 and 25 g/mL) were added 3 hours before coincubating H9c2 cardiomyoblasts with Dox (0.5 and 1 M) for 24 hours more. We measured cell mass and metabolic viability, mitochondrial transmembrane potential, superoxide anion content, and activity-like of caspase-3 and caspase-9 following treatment with the extracts and/or Dox. Also, selenium and vitamin C contents were measured in the plant extracts.
Results: The results confirmed that Dox treatment decreased cell mass, mitochondrial membrane potential and metabolic viability, increased mitochondrial superoxide anion, and stimulated caspase-3 and caspase-9-like activities. Pretreatment of the cells with the plant extracts significantly inhibited Dox cytotoxicity, with more significant results at the higher concentration. Measurements of selenium and vitamin C in the extracts revealed higher concentration of both when compared with other Cameroonian spices.
Conclusion: Both extracts of and were effective against Dox-induced cytotoxicity, most likely due to their content in antioxidants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920721 | PMC |
| http://dx.doi.org/10.1155/2021/8858165 | DOI Listing |
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