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Plant basic helix-loop-helix (bHLH) transcription factors are involved in the regulation of various biological processes in plant growth, development, and stress response. However, members of this important transcription factor family have not been systematically identified and analyzed in pepper ( L.). In this study, we identified 122 genes in the pepper genome and renamed them based on their chromosomal locations. were divided into 21 subfamilies according to their phylogenetic relationships, and genes from the same subfamily had similar motif compositions and gene structures. Sixteen pairs of tandem and segmental duplicated genes were detected in the CabHLH family. -elements identification and expression analysis of the revealed that they may be involved in plant development and stress responses. This study is the first comprehensive analysis of the genes and will serve as a reference for further characterization of their molecular functions.
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http://dx.doi.org/10.3389/fgene.2020.570156 | DOI Listing |
Food Sci Nutr
September 2025
Department of Biology, College of Natural and Computational Sciences Mizan-Tepi University Tepi Ethiopia.
Climatic challenges increasingly threaten global food security, necessitating crops with enhanced multi-stress resilience. Through systematic transcriptomic analysis of 100 wheat genotypes under heat, drought, cold, and salt stress, we identified 3237 differentially expressed genes (DEGs) enriched in key stress-response pathways. Core transcription factors (, , ) and two functional modules governing abiotic tolerance were characterized.
View Article and Find Full Text PDFJ Neurosci
September 2025
Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived progenitor cells (MGPCs) in the adult male and female mouse retina. We found that S1P-related genes were dynamically regulated following retinal damage. (S1P receptor 1) and (sphingosine kinase 1) are expressed at low levels by resting MG and are rapidly upregulated following acute damage.
View Article and Find Full Text PDFPlant Sci
September 2025
College of Life Sciences, Henan Normal University, Xinxiang 453007, China; Henan International Joint Laboratory of Aquatic Toxicology and Health Protection, College of Life Sciences, Henan Normal University, Xinxiang 453007, China. Electronic address:
Catalpol, one of the major bioactive components in the traditional Chinese medicinal herb Rehmannia glutinosa, exhibits multiple pharmacological activities such as hypoglycemic and neuroprotective effects. Consequently, mechanistic elucidation of catalpol biosynthesis regulation in R. glutinosa is critically important.
View Article and Find Full Text PDFFront Plant Sci
August 2025
Nanfan Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Sanya, Hainan, China.
Introduction: Transcription factors (TFs) are essential regulators of gene expression, orchestrating plant growth, development, and responses to environmental stress. , a halophytic species renowned for its exceptional salt resistance, provides an ideal model for investigating the regulatory mechanisms underlying salt tolerance.
Methods: Here, we present a comprehensive genome-wide identification and characterization of TFs in .
Front Biosci (Landmark Ed)
August 2025
General Surgery, Shanghai Pudong New District Traditional Chinese Medicine Hospital, 200120 Shanghai, China.
Background: The most common endocrine cancer, thyroid carcinoma (TC), has a dismal prognosis when it reaches an advanced stage. Integrin α-2 () has been implicated in cancer progression, influencing both DNA damage and repair mechanisms. However, it is unknown how ITGA2 influences these processes in TC.
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