Characterization and expression analysis of transcription factors in unveil their critical roles in salt stress resistance.

Introduction: Transcription factors (TFs) are essential regulators of gene expression, orchestrating plant growth, development, and responses to environmental stress. , a halophytic species renowned for its exceptional salt resistance, provides an ideal model for investigating the regulatory mechanisms underlying salt tolerance.

Methods: Here, we present a comprehensive genome-wide identification and characterization of TFs in .

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis.

Salt stress presents a substantial threat to cereal crop productivity, especially in coastal agricultural regions where salinity levels are high. Addressing this challenge requires innovative approaches to uncover genetic resources that support molecular breeding of salt-tolerant crops. In this study, a novel machine learning model, KANMB is introduced, designed to analyze integrated multi-omics data from the natural halophyte Spartina alterniflora under various NaCl concentrations.

Correlation of Doppler Pulmonary Artery Parameters With Gestational Age in Normal Fetuses at 20-32 Weeks.

Objective: To measure pulmonary artery (PA) diameters and Doppler values in normal fetuses and to analyze their trends and correlations with gestational age (GA).

Methods: We took PA ultrasound measurements of normal fetuses with GAs of 20-32 weeks, including the main pulmonary artery (MPA), right pulmonary artery (RPA), and left pulmonary artery (LPA) inner diameters and MPA Doppler parameters [acceleration time (AT), ejection time (ET), AT/ET ratio, peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility index (PI), and resistance index (RI)]. The subjects were divided into early (20-24 weeks), middle (24-28 weeks), and late (28-32 weeks) GA groups.

Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway.

Background: Hyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage to human pulmonary microvascular endothelial cells (HPMVECs) via the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) pathway.

Comprehensive analysis of the gene family reveals the regulatory role of in plant development.

Introduction: The gene family, prevalent in eukaryotes, assumes diverse roles in cellular processes. , a halophyte with exceptional salt tolerance, flood tolerance, reproduction, and diffusion ability, offers great potential for industrial applications and crop breeding analysis. The exploration of growth and development-related genes in this species offers immense potential for enhancing crop yield and environmental adaptability, particularly in industrialized plantations.

GSK-3β inhibitor TWS119 promotes neuronal differentiation after hypoxic-ischemic brain damage in neonatal rats.

Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis after hypoxic-ischemic brain damage in neonatal rats remains unclear.

A study protocol for investigating the sonographic characteristics of neonates with critical illness: an observational cohort study.

Background: Haemodynamic instability and hypoxaemia are common and serious threats to the survival of neonates. A growing body of literature indicates that critical care ultrasound has become the optimal evaluation tool for sick neonates. However, few studies have described sonographic characteristics of haemodynamics systematically in the neonates with critical illness.

Noninvasive high-frequency oscillatory ventilation versus nasal intermittent positive pressure ventilation for preterm infants as an extubation support: A systematic review and meta-analysis.

Objective: We aimed to explore whether noninvasive high-frequency oscillatory ventilation (NHFOV) could reduce the incidence of reintubation compared with nasal intermittent positive pressure ventilation (NIPPV) in the postextubation phase of preterm infants.

Methods: Randomized controlled trials of NHFOV versus NIPPV were searched in PubMed, EMBASE, Cochrane Central, and MEDLINE. Meta-analysis was performed using Review Manager 5.

Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury.

Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on.

[Effect of Anti-Oxidative of Ethyl Pyruvate and Taurine on the Red Blood Cell Storage at 4 ℃].

Objective: To investigate the anti-oxidative effect of ethyl pyruvate (EP) and taurine (TAU) on the quality of red blood cells stored at 4±2 ℃, hemolysis, energy metabolism and lipid peroxidation of the red blood cells in the preservation solution were studied at different intervals.

Methods: At 4±2 ℃, the deleukocyte red blood cells were stored in the citrate-phosphate-dextrosesaline-adenine-1 (CPDA-1) preservation (control group), preservation solution with EP (EP-AS), and TAU (TAU-AS) for long-term preservation. The enzyme-linked immunoassay and automatic blood cell analyzer were used to detect hemolysis and erythrocyte parameters.

Systematic review and meta-analysis: the effect of bronchopulmonary dysplasia on neurodevelopment in very low birth weight premature infants.

Background: A meta-analysis was performed to study the effect of steroid intervention on the neurodevelopment of extremely low birth weight preterm infants complicated with bronchopulmonary dysplasia, and to provide a theoretical basis for clinical treatment.

Methods: The Wanfang database, Chinese Biomedical Literature database, VIP database, Baidu Academic, CNKI database, The Cochrane Library, Medline, Embase, and PubMed database were searched by computer from establishment to 2021. Randomized controlled trials on the effect of steroids on neurodevelopment in very low birth weight preterm infants with bronchial dysplasia published from January 10, 2007 were retrieved.

Endothelial Progenitor Cell-Derived Microvesicles Promote Angiogenesis in Rat Brain Microvascular Endothelial Cells .

Brain microvascular endothelial cells (BMECs) are a major component of the blood-brain barrier that maintains brain homeostasis. Preserving and restoring the normal biological functions of BMECs can reverse or reduce brain injury. Endothelial progenitor cells (EPCs) may promote brain vascular remodeling and restore normal endothelial function.

A 3-armed multicenter randomized controlled trial: Placental Transfusion in Very Preterm Infants (PT-VPI).

Preterm infants constitute an important proportion of neonatal deaths and various complications, and very preterm infants (VPI) are more likely to develop severe complications, such as intraventricular hemorrhage (IVH), anemia, and sepsis. It has been confirmed that placental transfusion can supplement blood volume in infants and reduce preterm-associated complications, which is further conducive to the development of the nervous system and a better long-term prognosis. Based on these advantages, placental transfusion has been widely used in VPI.

Hydrocortisone to treat early bronchopulmonary dysplasia in very preterm infants: study protocol for a randomized controlled trial.

Background: Bronchopulmonary dysplasia (BPD) is still a common complication in very premature infants. At present, there is no effective treatment for BPD. Glucocorticoids are drugs commonly used to prevent or treat BPD before and after birth.

The application value of lung ultrasound findings in preterm infants with bronchopulmonary dysplasia.

Background: The purpose of this study was to investigate the association between ultrasound findings and preterm infants with bronchopulmonary dysplasia (BPD).

Methods: Preterm infants with a gestation age of less than 28 weeks or birthweight less than 1,500 g admitted to the neonatal intensive care unit (NICU) in the Chengdu Women's & Children's Central Hospital from June 2018 to June 2019 were enrolled in the study and divided into 2 groups: the BPD group and the non-BPD group. All clinical data and lung ultrasound were retrospectively analyzed.

[Value of bedside lung ultrasound in the diagnosis of neonatal pneumonia].

Objective: To study the value of bedside lung ultrasound in the diagnosis of neonatal pneumonia.

Methods: A total of 49 neonates who were admitted to the Neonatal Intensive Care Unit of Chengdu Women and Children's Central Hospital in March 2017 with respiratory symptoms as the chief complaint were enrolled. Bedside lung ultrasound was performed within 24 hours after admission.

Application of low field NMR T2 measurements to clathrate hydrates.

Low field (2 MHz) Nuclear Magnetic Resonance (NMR) proton spin-spin relaxation time (T(2)) distribution measurements were employed to investigate tetrahydrofuran (THF)-deuterium oxide (D(2)O) clathrate hydrate formation and dissociation processes. In particular, T(2) distributions were obtained at the point of hydrate phase transition as a function of the co-existing solid/liquid ratios. Because T(2) of the target molecules reflect the structural arrangements of the molecules surrounding them, T(2) changes of THF in D(2)O during hydrate formation and dissociation should yield insights into the hydrate mechanisms on a molecular level.

NMR/MRI study of clathrate hydrate mechanisms.

Clathrate hydrates are of great importance in many aspects. However, hydrate formation and dissociation mechanisms, essential to all hydrate applications, are still not well understood due to the limitations of experimental techniques capable of providing dynamic and structural information on a molecular level. NMR has been shown to be a powerful tool to noninvasively measure molecular level dynamic information.

Detecting gas hydrate behavior in crude oil using NMR.

Because of the associated experimental difficulties, natural gas hydrate behavior in black oil is poorly understood despite its grave importance in deep-water flow assurance. Since the hydrate cannot be visually observed in black oil, traditional methods often rely on gas pressure changes to monitor hydrate formation and dissociation. Because gases have to diffuse through the liquid phase for hydrate behavior to create pressure responses, the complication of gas mass transfer is involved and hydrate behavior is only indirectly observed.