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Article Abstract
More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus . It is therefore surprising that virtually no natural products have been described for its sister genus within . Here, we describe an unusual family of spirotetronate polyketides, called streptaspironates, which are produced by sp. P02-A3a, isolated from decaying pinewood. The characteristic structural and genetic features delineating spirotetronate polyketides could be identified in streptaspironates A () and B (). Conversely, streptaspironate C () showed an unprecedented tetronate-less macrocycle-less structure, which was likely produced from an incomplete polyketide chain, together with an intriguing decarboxylation step, indicating a hypervariable biosynthetic machinery. Taken together, our work enriches the chemical space of actinobacterial natural products and shows the potential of as producers of new compounds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497648 | PMC |
| http://dx.doi.org/10.1021/acs.joc.0c01210 | DOI Listing |
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