Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Atherosclerosis is considered a chronic inflammatory disease of arteries associated with the aging process. Many risk factors have been identified and they are mainly related to life-styles, gene-environment interactions and socioeconomic status. Carotid and coronary artery diseases are the two major atherosclerotic conditions, being the primary cause of stroke and heart attack, respectively. Nevertheless, carotid plaque assumes particular aspects not only for the specific molecular mechanisms, but also for the types of atheroma which may be associated with a better or a worst prognosis. The identification of circulating blood biomarkers able to distinguish carotid plaque types (stable or vulnerable) is a crucial step for the improvement of adequate therapeutic approaches avoiding or delaying endarterectomy in the oldest old individuals (> 80 years), a population predicted to growth in the next years. The review highlights the most recent knowledge on carotid plaque molecular mechanisms, focusing on microRNAs (miRs), as a site-specific accelerated aging within the conceptual framework of Geroscience for new affordable therapies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arr.2020.101090 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between remnant cholesterol and atherosclerosis plaques in single and multiple vascular territories.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Hepatobiliary and Pancreatic Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: In recent years, the role of remnant cholesterol (RC) in the development and progression of cardiovascular diseases has gained increasing attention. However, evidence on the association between RC and subclinical atherosclerosis is limited. This study aims to examine the relationship between RC and atherosclerotic plaques in single and multiple vascular territories.
View Article and Find Full Text PDFMachine Learning Models for Carotid Artery plaque Detection: A Systematic Review of Ultrasound-Based Diagnostic Performance.
J Stroke Cerebrovasc Dis
September 2025
College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.. Electronic address:
Background: Carotid artery plaques, a hallmark of atherosclerosis, are key risk indicators for ischemic stroke, a major global health burden with 101 million cases and 6.65 million deaths in 2019. Early ultrasound detection is vital but hindered by manual analysis limitations.
View Article and Find Full Text PDFDevelopment and Validation of a Prediction Model for Acute Ischemic Stroke Based on a Novel Ultrasound-Based Carotid Plaque Scoring System and Clinical Factors.
J Clin Ultrasound
September 2025
Hebei General Hospital, Shijiazhuang, China.
Background: Acute ischemic stroke (AIS) is characterized by high incidence, sudden onset, and often poor prognosis. Carotid atherosclerosis plays a crucial role in its pathogenesis, and ultrasound imaging offers a non-invasive method for evaluating carotid plaque characteristics. This study aimed to develop and validate a prediction model for AIS risk based on a novel ultrasound-based carotid plaque scoring system combined with clinical risk factors.
View Article and Find Full Text PDFSingle-Cell RNA Sequencing Reveals Granzyme K CD8 T Cells as a Target for Mitigating Plaque Instability Following Radiation.
J Am Heart Assoc
September 2025
Background: Cardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy-induced plaque instability and changes in plaque characteristics on imaging remain unclear. This study used single-cell RNA sequencing to identify key features of vulnerable plaques following radiotherapy.
View Article and Find Full Text PDFEvaluation of risk factors for acute stroke using combined CTA and MR HR-VWI imaging.
Front Neurol
August 2025
Department of Medical Imaging Center, Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
Objective: To investigate the correlation between the changes of peripheral carotid fat density (PFD), the occurrence of acute cerebral ischemia events and the characteristics of different dangerous plaques.
Methods: A retrospective analysis was performed on patients diagnosed with carotid plaque by head and neck CTA in the Affiliated Hospital of Qinghai University from January 2021 to March 2023. All patients received head magnetic plain scan, DWI and high resolution vascular wall imaging (MR HR-VWI).