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Article Abstract
In search of unprecedented tri and/or tetrapod pharmacophoric conjugates, a series of 32 new 4-ethyl-1-benzo[][1,4]diazepin-2(3)-ones were synthesized and properly elucidated using MS, IR, NMR, and elemental analysis. investigation of 11 compounds of this series, using a panel of two human tumor cell lines namely; human breast adenocarcinoma (MCF-7), and human colorectal carcinoma (HCT-116), revealed promising cytotoxic activities. Among all synthesized compounds, analogue displayed maximum cytotoxicity with IC values of 16.19 ± 1.35 and 17.16 ± 1.54 μM against HCT-116 and MCF-7, respectively, compared to standard drug doxorubicin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248725 | PMC |
| http://dx.doi.org/10.3390/molecules25092051 | DOI Listing |
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