Synthesis and antifungal activity of novel pyrazolines and isoxazolines derived from cuminaldehyde.

J Pestic Sci

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R. China.

Published: August 2019


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Article Abstract

Two series of novel cuminaldehyde derivatives containing pyrazoline and isoxazoline moieties have been designed and synthesized. All of the compounds were characterized H-NMR,C-NMR, and HRMS. The antifungal activities were evaluated against six plant-pathogenic fungi. 3-(2-Fluorophenyl)-5-(4-isopropylphenyl) isoxazoline () and 1-acetyl-3-(2-fluorophenyl)-5-(4-isopropylphenyl)-2-pyrazoline () displayed higher antifungal activities than commercial fungicides against , and . The title compounds ( and ) with strong antifungal activities are worth being further evaluated and in the field.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718356PMC
http://dx.doi.org/10.1584/jpestics.D19-028DOI Listing

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