Retrospective Study of Pediatric Sinonasal Tumors in a Tertiary Hospital Setting.

BACKGROUND Pediatric sinonasal tumors are rare, accounting for about 4% of all pediatric head and neck neoplasms. Due to their nonspecific symptoms such as nasal obstruction, epistaxis, and facial pain, these tumors often present diagnostic challenges and lead to delays in managment. Early and accurate diagnosis is crucial to optimize clinical outcomes.

An Analysis of Mental Health, Subjective Well-Being, and Self-Efficacy Among Nurses in the Qassim Health Cluster: Identification of Risk Levels.

Introduction: Nurses are the cornerstone of the healthcare system, playing a vital role in delivering consistent, high-quality patient care. However, working in high-stress environments such as hospitals and health clusters exposes them to ongoing well-being, emotional, and psychological challenges. If unaddressed, these factors can significantly compromise their mental health, subjective well-being, and self-efficacy, ultimately affecting workforce sustainability and patient outcomes.

Comparison of fine needle aspiration of thyroid nodules and lymph nodes with 22- and 25-gauge needles: a retrospective study.

Background: Approximately 15% of fine-needle aspiration biopsy (FNAB) procedures are considered inconclusive, caused by various factors such as nodule characteristics, level of expertise, and needle size. Since needle size may play a crucial role in both adequacy of FNAB samples and reduction of complications, our objective was to compare cytology specimen adequacy, blood contamination, and findings in thyroid nodules and lymph nodes using 22- and 25-gauge needles in fine-needle aspiration (FNA).

Materials And Methods: A retrospective comparative cohort study was conducted at King Fahad Specialist Hospital, Saudi Arabia.

Endoscopic ultrasound-guided radiofrequency ablation of pancreatic tumors: Current status and future perspectives.

Pancreatic neoplasms present a significant therapeutic challenge due to their complex anatomy and poor prognosis. In recent years, endoscopic ultrasound guided radiofrequency ablation (EUS-RFA) has emerged as a promising minimally invasive therapeutic option, aiming to provide targeted treatment with improved patients' outcomes. This review aims to shed light on current evidence about the efficacy, safety, and clinical outcomes of EUS-RFA in the management of pancreatic neoplasms.

Platelet-Rich Fibrin as a True Bone Graft Substitute: A Systematic Review and Meta-Analysis of Its Osteogenic Potential in Dental and Maxillofacial Surgery.

Platelet-rich fibrin (PRF) has gained popularity as an autologous biomaterial used to enhance bone healing. This systematic review and meta-analysis aimed to assess whether the use of PRF alone achieves comparable osteogenic outcomes to conventional bone grafts. It involved a comprehensive search of the databases PubMed, Scopus, and Google Scholar for articles published from 2019-2024, seeking to identify clinical studies comparing PRF alone to grafts or controls in bone regeneration procedures.

Incidence of PEG-Asparaginase-Induced Pancreatitis in Children During Acute Lymphoblastic Leukemia Treatment: A Multicenter Study.

Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer globally. PEG-asparaginase (PEG-ASPA), a cornerstone of ALL treatment, significantly improves outcomes but is associated with serious toxicities, including acute pancreatitis (AP). This study evaluates the incidence and associated risk factors of PEG-ASPA-induced AP among pediatric ALL patients in Saudi Arabia.

Revolutionizing cross professional collaboration outcomes in TBI: emerging trends in diagnostics, personalized medicine, technological innovations and neurorehabilitation.

Traumatic brain injury (TBI) is still considered a major cause of morbidity and mortality worldwide, and its prevalence is increasing daily. TBI patients are facing difficult diagnostic, management, and rehabilitative challenges. This review article represents the most relevant recent findings in all areas of TBI concerning pathophysiology, diagnostics, therapeutics, rehabilitation approaches and neuroplasticity.

A Descriptive Study of Caregivers' Awareness, Practices, Challenges Faced, and Methods of Adherence to the Ketogenic Diet in Children with Refractory Epilepsy.

: Refractory epilepsy refers to a type of epilepsy in which anti-epileptic medications do not yield results, necessitating alternative medical interventions. The ketogenic diet (KD) is utilized as a non-pharmacologic treatment for refractory epilepsy. This study aims to assess details regarding caregivers' awareness and practices, challenges faced, and other details regarding the KD as a treatment option for children with refractory epilepsy.

Vulvar dermatofibrosarcoma protuberans, an unusual anatomical location.

Vulvar dermatofibrosarcoma protuberans (DFSP) is a rare pathology. So far, only limited number of cases have been reported in literature. In the present case, we discuss a 38-year-old female presented with a painful left vulvar mass.

Is That a Tooth I See? Ovarian Teratoma on POCUS.

Ovarian teratomas (OT) are rarely first diagnosed in the emergency department (ED) setting. They are less likely to present with acute symptoms unless associated with more serious pathological conditions, such as ovarian torsion, which is considered a gynecological emergency that patients with OT are at risk of developing. We present a patient who complained of abdominal pain, and was diagnosed with an OT using Point-of-care ultrasound (POCUS).

Endoscopic ultrasound training: Current state, challenges, and the path to proficiency.

Endoscopic ultrasound (EUS) is an indispensable tool for the diagnosis and management of various diseases, particularly biliopancreatic disorders, as it provides detailed visualization of the gastrointestinal tract and surrounding structures. As the demand for diagnostic and interventional EUS procedures increases, ensuring high-quality training for endoscopists is essential to improve patient outcomes. This mini-review provides an overview of the current state of EUS training and emphasizes the importance of a structured approach that integrates theoretical knowledge and hands-on experience.

CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder characterized by the death of motor neurons in the spinal cord and brain regions, leading to a reduced survival rate in patients. Nearly 20 gene mutations are associated with ALS, with SOD1, FUS, TARDBP, and C9orf72 mutations being more common. Ninety percent of ALS cases are related to sporadic ALS, while the remaining 10 % are associated with familial ALS.

Mapping antimicrobial susceptibility of community-acquired uropathogenic Escherichia coli across low, middle and high-income countries highlights significant differences: insights for empiric treatment.

Objectives: Rising antimicrobial resistance (AMR) in urinary tract infections (UTI) poses a global challenge. Evidence-based treatment of cystitis requires local resistance data. The DASH to Protect Antibiotics (https://dashuti.

Prevalence of Irritable Bowel Syndrome and Its Association With Anxiety Among Family Physicians in Primary Healthcare in Tabuk, Saudi Arabia.

Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder influenced by multiple psychosocial factors, including anxiety. Physicians, particularly those working in primary healthcare settings, are exposed to high occupational stress, potentially increasing their risk for both anxiety and IBS.

Objective: This study aimed to determine the prevalence of IBS among family physicians in Tabuk, Saudi Arabia, and to explore its association with anxiety levels.

Postoperative Pedicle Fracture in an Adult With Idiopathic Scoliosis After Posterior Spinal Fusion: A Case Report.

This case report presents the case of a 22-year-old female patient with a history of adolescent idiopathic scoliosis who underwent posterior spinal fusion and instrumentation from T4 to L5 at age 17. Her postoperative course was uneventful for five years, during which she remained asymptomatic and functionally independent. At age 22, she developed insidious axial low back pain without trauma or neurological symptoms.

Modulating food craving-related neural oscillations using tACS: study protocol for a randomized sham-controlled trial.

Introduction: Food addiction is characterized by heightened craving and impaired inhibitory control, contributing to compulsive eating and obesity. Existing behavioral and pharmacological interventions often fail to achieve lasting effects. Transcranial alternating current stimulation (tACS), by modulating neural oscillations and connectivity, offers a novel, non-invasive approach for regulating craving-related neural circuits.

Plantar Ulcerative Lichen Planus as a Therapeutic Challenge: A Review of Literature.

Plantar ulcerative lichen planus (PULP) is a rare variant of lichen planus (LP), with fewer than 20 cases reported in the literature. It presents as chronic, painful ulcers on the soles, often without other classic LP manifestations. The condition remains poorly understood, with unclear pathogenesis and no standardized treatment.

Prevalence of Obsessive-Compulsive Symptoms Among University Students in Tabuk: A Cross-Sectional Study.

Background: Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder that can significantly impair functioning and well-being. While OCD has been extensively studied in various populations, data on its prevalence among university students in the Tabuk region of Saudi Arabia remain limited.

Objective: To determine the prevalence of obsessive-compulsive symptoms among students at Tabuk University and explore their association with demographic and academic characteristics.

Pioneering SMA therapies for all types: survival gains, cost dynamics, and performance-based agreements.

Background: The purpose of this study was to assess the impact of survival improvements and performance-based managed entry agreements (PBMEAs) on the cost implications of introducing innovative spinal muscular atrophy (SMA) treatments, nusinersen, onasemnogene abeparvovec, and risdiplam, for managing SMA Types 1, 2, and 3 from the perspective of the Saudi Ministry of Health (MoH).

Methods: A budget impact model was created using inputs such as total population, market share, median survival, and resource utilization obtained through literature review and validated by expert committees. The model projected the overall cost (drug acquisition, administration, and disease management) for best supportive care (BSC) with and without these interventions over a 5-year period using Microsoft Excel as the analytical tool.

Primary reconstruction of depressed frontal bone fracture including cranialization of frontal sinus and repair of forehead skin: a case report and literature review.

Background: Traumatic brain injuries (TBIs) are significant causes of morbidity and mortality worldwide. A compound depressed skull fracture (DSF) occurs when a laceration over the fracture exposes the internal cranial cavity to the external environment. DSFs are considered surgical emergencies that require prompt intervention to reduce morbidity and mortality.

Outcome of two siblings with late-onset Krabbe disease following allogeneic hematopoietic stem cell transplantation: And review of literature.

Objectives: To compare delayed-onset Krabbe disease (KD) and outcomes between two siblings in relation to allogeneic hematopoietic stem cell transplantation (HSCT).

Methods: We provide a descriptive report on two siblings with late-onset KD and their clinical course before and after HSCT.

Results: The index case presented with neurological symptoms that were presumptively diagnosed with multiple sclerosis (MS).

Surgeons Knowledge, Attitude, and Practice Toward Preoperative Inflammatory Bowel Disease Medications and Post-Operative Complications.

Background: Biologics, particularly anti-TNF agents, have transformed the management of inflammatory bowel disease (IBD), but concerns about their perioperative safety persist.

Objective: This study evaluates the knowledge, attitudes, and practices of surgeons in Saudi Arabia regarding the preoperative management of IBD patients undergoing surgery while on biological treatments.

Methods: A cross-sectional survey was conducted among 115 surgeons.

Efficacy and Safety of 1 L PEG-ASC Preparation for Colonoscopy in Patients with Inflammatory Bowel Diseases: A Multicenter Observational Study.

: The effectiveness of 1 L PEG-ASC preparation in inflammatory bowel disease (IBD) patients is still unclear. The aim of this study was to determine the efficacy and safety of 1 L PEG-ASC in a series of IBD patients. : Data from a study conducted on a series of 284 patients collected in three centers between 2020 and 2025 were analyzed.

Solitary fibrous tumor of the nasal septum: a case report and literature review.

Solitary fibrous tumors (SFT) are rare spindle cell neoplasms of mesenchymal origin, typically occurring in the pleura, with extra-pleural manifestations being uncommon. SFTs of the nasal cavity are particularly rare, with limited cases documented in the literature. This report presents the case of a 62-year-old female with a solitary fibrous tumor arising from the nasal septum.

Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data.

Early prediction of disability progression in multiple sclerosis (MS) remains challenging despite its critical importance for therapeutic decision-making. We present the first systematic evaluation of personalized federated learning (PFL) for 2-year MS disability progression prediction, leveraging multi-center real-world data from over 26,000 patients. While conventional federated learning (FL) enables privacy-aware collaborative modeling, it remains vulnerable to institutional data heterogeneity.