Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Tubeimoside-1 (TBMS1) is one of the extracts of rhizoma bolbostemmae, which has remarkable anti-cancer function in the treatment of esophagus and gastric cancer in traditional Chinese medicine. However the mechanisms of its anti-cancer function is remain unclear. In this study, we demonstrate that TBMS1 could inhibit cell growth and metastasis in glioblastoma. MET is a member of the receptor tyrosine kinase family, which amplifies frequently in various human cancers. As an important proto-oncogene, multiple inhibitors have been developed for the therapy of cancers. Here, we found TBMS1 could reduce/decrease the protein level of MET via increasing its Ubiquitination degradation. Therefore, TBMS1 is a promising compound for the treatment of glioblastoma and an inhibitor of MET.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721480 | PMC |
| http://dx.doi.org/10.3390/cells8080774 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nanoengineered Scheelite-Structured SrWO Decorated on MXene Sheets: A Novel Platform for Electrochemical Sensing of the Anti-Cancer Drug Nilutamide with DFT Insights.
Environ Res
September 2025
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan; High-value Biomaterials Research and Commercialization Center, National Taipei University of Technology, Taipei 10608, Taiwan. Electronic address:
The persistent presence of the pharmaceutical pollutant nilutamide (NLT) in environmental and biological systems poses a serious threat to ecosystems and human health, necessitating efficient and sustainable detection strategies. In this study, we present a nanoengineered SrWO@MXene electrocatalyst as a high-performance platform for electrochemical sensing. The hybrid material seamlessly integrates the catalytic activity and electrochemical stability of SrWO with the exceptional conductivity and tunable surface chemistry of MXenes, resulting in a synergistic architecture optimized for rapid and selective NLT detection.
View Article and Find Full Text PDFElucidating the correlation between polychlorinated dibenzo-p-dioxins and prostate cancer progression: Insights from gene expression and molecular docking.
Ecotoxicol Environ Saf
September 2025
Department of Urology, Urology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Department of Urology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China; Fujian Key Labo
Objective: Polychlorinated dibenzo-p-dioxins (PCDDs) present a significant long-term threat to human health attributable to their toxicological properties, chemical stability and propensity for bioaccumulation. This study seeks to explore the correlation between PCDDs exposure and prostate cancer (PCa) through comprehensive analysis.
Methods: The multi-dimensional analysis was conducted based on various online databases.
Dual-Functional Nanoliposome with High BPA Loading for Targeted MRI-Guided BNCT of Glioblastoma.
ACS Appl Mater Interfaces
September 2025
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Glioblastoma is a highly malignant brain tumor with few available therapeutic options, for which boron neutron capture therapy (BNCT) has emerged as a promising precision radiotherapy approach. However, its efficacy remains suboptimal due to inadequate tumor targeting of boron agents and lack of in vivo visualization. Herein, a gadolinium-boron integrated lipid nanocarrier (BPA-F&DOTA-Gd@LIPO-ANG) was developed for targeted boron delivery and MRI-guided BNCT.
View Article and Find Full Text PDFChromatin-associated circRNA ciCRLF3(2) regulates cell differentiation blockage via activating non-homologous end joining-based DNA repair.
Cell Death Differ
September 2025
MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
DNA damage response (DDR) is a complicated network that responds to DNA lesions to prevent their accumulation; a defective DDR is one hallmark of cancer. Although targeting DDR pathways has been considered as a therapeutic approach, DDR inhibitors have also been reported ineffective for treating some low mutation burden cancers, such as Mixed-lineage leukemia (MLL)-rearranged (MLL-r) leukemia, a clinically fatal and refractory malignancy. Exploring the roles and mechanisms of DDR pathways in these low mutation burden cancers may help understand the chromatin biology and develop therapeutic strategies.
View Article and Find Full Text PDFEstablishing the China-UK Cancer Prevention and Control Alliance.
Lancet Oncol
September 2025
Xijing Hospital, Shaanxi, China.