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Objectives: This pilot study aimed to evaluate the feasibility of prospectively collecting electronic PROMs on patients being assessed as a result of musculoskeletal trauma, using a web-based application (APP), administered onto tablet and desktop computers (TCs or DCs) in the outpatient setting.
Methods: Following local research ethics approval, a web-based APP (TRAFIC) was developed. It consisted of a total of 12 questions (demographic information, employment, and rehabilitation status as well as quality of life (EQ5D)). The APP was viewable on TCs, with DCs being used in review cubicles when necessary with assistance from a medical professional. Eligible patients were invited to use TRAFIC during the 'Lag period'; the time period from the patient 'booking in' to 'being called' for their appointment. An evaluation of the total time spent using the app (APP-time), was recorded as well as the total time spent in the outpatient department (CLINIC-time) for all patients recruited. CLINIC-time was also assessed for a control group of patients not utilising the APP during their outpatient assessment.
Results: One hundred patients were recruited for the study n = 50 males, n = 50 females with a mean age of 49.1 (± 17.6 years). All recruited patients completed the questionnaire items with a median APP-time of 5 min (range 2-118 min). The median 'Lag period' was 16 min. (Range 2-166 min), with a median CLINIC-time of 81 min (range 4-428). The CLINIC-time was higher than for the control group (median 67 min (range 18-242) but this was not statistically significant (Mann Whitney U test; p = 0.199).
Conclusions: Electronic PROMs collection in the musculoskeletal trauma outpatient clinic using a web-based APP is feasible, with the APP-time falling well within the 'Lag period', and no significant impact on the total time spent for the appointment.
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http://dx.doi.org/10.1016/j.injury.2018.09.030 | DOI Listing |
Environ Epidemiol
October 2025
School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Background: Seasonal variation in mortality results from a combination of environmental, biological, and social factors, with ambient temperature recognized as a key contributor. However, comprehensive assessments disentangling temperature effects from other seasonal influences across a broad range of mortality causes remain limited. This study aimed to quantify and compare the mortality burden attributable to ambient temperature and broader seasonal variation across major causes of death in Spain.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Artificial Intelligence and Mathematical Modeling Lab, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Background: The H5N1 avian influenza A virus represents a serious threat to both animal and human health, with the potential to escalate into a global pandemic. Effective monitoring of social media during H5N1 avian influenza outbreaks could potentially offer critical insights to guide public health strategies. Social media platforms like Reddit, with their diverse and region-specific communities, provide a rich source of data that can reveal collective attitudes, concerns, and behavioral trends in real time.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environm
New evidence has revealed ambient fine particulate matter < 2.5 μm (PM) may have endocrine disrupting effect, such as thyroid hormone disorder, while which PM constituents contributed to the effect was debatable. The study aimed to identify the specific PM constituents regarding to acute endocrine disrupting effect.
View Article and Find Full Text PDFIndian J Endocrinol Metab
August 2025
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction: Ectopic adrenocorticotropic hormone (ACTH)/corticotropin-releasing hormone production by tumours causes 5-10% of Cushing's syndrome cases. We present a 21-patient case series with ectopic Cushing's syndrome (ECS) from a tertiary care institute in India.
Methods: Data were collected retrospectively for patients from 1984 to 2004 and prospectively thereafter till 2019.
Clin Pharmacol Ther
September 2025
School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
This cross-sectional study aims to demonstrate the impact of China's 2015 review and approval reform on the delays in market entry for novel geriatric drugs, as well as the capability of domestic innovation in developing geriatric drugs. We analyzed the novel geriatric drugs approved by the US Food and Drug Administration (FDA) between 2005 and 2024 to assess the drug lags in China by using the EU and Japan as comparators. During this period, the FDA approved a total of 183 novel drugs targeting geriatric diseases, of which 109 were also approved by the NMPA.
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