98%
921
2 minutes
20
Download full-text PDF |
Source |
---|
Sci Adv
September 2025
Key Laboratory of Soybean Disease and Pest Control (Ministry of Agriculture and Rural Affairs), Key Laboratory of Plant Immunity, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Salicylic acid (SA) is a key defense hormone shaped by temperature. High temperatures suppress, while low temperatures enhance, SA biosynthesis and signaling, thereby influencing plant immunity and temperature resilience. This review synthesizes current understanding of how temperature modulates SA pathways and their cross-talk with other hormones to balance growth and defense.
View Article and Find Full Text PDFSci Adv
September 2025
Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300350, China.
Acoustic tweezers leverage acoustic radiation forces for noncontact manipulation. One of the core bottlenecks in multidimensional manipulation is the lack of a systematic design methodology, which prevents the generation of an acoustic field that simultaneously meets the collaborative control requirements of multi-degree-of-freedom forces and torques, making it difficult to achieve precise control under conditions of stable suspension, high-frequency rotation, and complex spatial constraints. To address this challenge, we develop an end-to-end inverse design methodology for acoustic tweezers based on coding metasurfaces, establishing a dual-objective, dual-scale optimization paradigm.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
College of Chemistry and Molecular Sciences, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430072, P. R. China.
The in-depth integration of gene regulation with protein modulation can enhance cellular information processing, yet it is significantly constrained by ineffective and complex protein-to-gene transduction strategies. Herein, we developed a simple protease-guided autocatalytic gene silencing platform named iPAD (intelligent peptide-programmed deoxyribonuclease) that converts the protease recognition events into versatile DNA readout signals by rationally designing a native protease-responsive cationic peptide (PP) to efficiently modulate the DNAzyme (Dz) activity. Without requiring additional chemical modifications, the multifunctional PP regulator consists simply of one cell-specific targeting peptide segment and two cationic peptide segments isolated by one protease-specific peptide substrate.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
In eukaryotic systems, three major types of cell junctions have been well characterized. While bacterial adhesion mechanisms also exhibit remarkable diversity, the molecular processes that regulate the dynamic modulation of binding strength between elongated bacterial cells and host cells remain poorly understood. () utilizes the surface adhesin CbpF to interact with the highly expressed host receptors CEACAM1 and CEACAM5 on cancer cells to facilitate tumor colonization.
View Article and Find Full Text PDFCereb Cortex
August 2025
Department of Psychology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical hearing remains unclear. This study examined adaptation to unilateral CI use in the first and seventh months after CI activation using speech comprehension measures and electroencephalography recordings, both during passive listening and an active spatial listening task.
View Article and Find Full Text PDF