Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Since 2001 livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) has increased in Denmark. Transmission to people happens by contact with livestock and mainly pigs. The prevalence in animals is not known but the bacterial reservoir is huge. The incidence of human isolates is increasing. However, LA-MRSA seems to be less virulent than non-LA-MRSA. Well-designed studies focusing on LA-MRSA infection, carrier status and risk factors in populations at risk are needed in order to provide solid data of the health consequences due to this rural, mainly occupational exposure.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Screening extracts for antimicrobial compounds against methicillin-resistant and helper-compounds against aminoglycoside-resistant .
Open Res Eur
September 2025
Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, 1870, Denmark.
Background: Innovative antibiotic discovery strategies are urgently needed to successfully combat infections caused by multi-drug-resistant bacteria.
Methods: We employed a direct screening approach to identify compounds with antimicrobial and antimicrobial helper-drug activity against Gram-positive and Gram-negative bacteria. We used this platform in two different strains of methicillin-resistant (MRSA) and aminoglycoside-resistant strains of to screen for antimicrobials compounds, which potentiate the activity of aminoglycoside antibiotics.
Therapeutic Efficacy and Drug Metabolism of Griseorhodin A Induced by a Co-culture of Actinomycete Strain TMPU-20A002 and Mycobacterium smegmatis in Silkworm Infection Models.
Chem Pharm Bull (Tokyo)
September 2025
Division of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
In screening for antibacterial agents from co-cultures of Mycobacterium smegmatis and microbial resources, such as actinomycetes and fungi, the known hydroxyquinone antibiotic griseorhodin A (1) was isolated from a co-culture of actinomycete strain TMPU-20A002 and M. smegmatis. Compound 1 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE), with minimum inhibitory concentrations of 0.
View Article and Find Full Text PDFInjectable and tissue adhesive chrysomycin A-laden chitosan hydrogel depot for MRSA-infected wound healing and tumor recurrence prevention.
Int J Biol Macromol
September 2025
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals & College of Pharmaceutical Science, Zhejiang University of Technology, 310014, Hangzhou, China. Electronic address:
Tumor surgery often leads to tumor residue, tissue defects, and drug-resistant bacterial infections, resulting in high recurrence rates and chronic wounds. In this study, an injectable hydrogel was synthesized using glycidyl trimethyl ammonium chloride-chitosan (GCh) and formylbenzoic acid-modified chrysomycin A (CA)-loaded F127 micelles (F127FA-CA). The formation of the hydrogel is achieved through Schiff base conjugation, which occurs between the amino groups present in GCh and the aldehyde groups located on the micelle surfaces.
View Article and Find Full Text PDFEsculetin Mitigates MRSA Pathogenicity via Innovative Multitarget Inhibition of Staphylococcus aureus Sortase A, Coagulase, and Von Willebrand Factor-binding Protein.
Int J Antimicrob Agents
September 2025
Department of Pediatric Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:
The global proliferation of antibiotic-resistant Staphylococcus aureus, particularly methicillin-resistant Staphylococcus aureus (MRSA), highlights the urgent need for innovative antivirulence strategies. The redundancy and multiplicity of virulence factors produced by S. aureus necessitate interventions capable of concurrently targeting multiple virulence mechanisms.
View Article and Find Full Text PDFStaphylococcus aureus manipulates osteocytes to cause persistent chronic osteomyelitis and antibiotic resistance via pyroptosis pathway suppression.
Drug Resist Updat
September 2025
Department of Orthopaedic Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. Electronic address: fangxinyu0417
Aims: In chronic osteomyelitis, the cortical bone serves as the primary site for long-term persistence of Staphylococcus aureus (S. aureus), the present study aimed to explore the mechanisms of immune evasion and antibiotic resistance remain incompletely understood.
Methods: Clinical methicillin-resistant S.