Mapping the Relationship Between Diffusion Characteristics of Warm-Mix Recycled Asphalt on Molecular Dynamics (MD) and High-Low Temperature Properties of Mixtures.

Warm-mix recycled asphalt (WMA-R) technology for reclaimed asphalt pavement (RAP) significantly reduces energy consumption and environmental pollution while maintaining the performance of asphalt mixtures. Significant progress has been made at home and abroad in evaluating the impact of regenerated asphalt mixtures on the performance of regenerated asphalt. However, the performance improvement of WMA-R depends on the effective diffusion of regenerated agents and their interaction mechanism with aged asphalt, which has not been fully studied.

Highly Efficient Perovskite/Organic Hybrid White Electroluminescent Devices with Extended Operational Lifetime and Wide Color Gamut.

Rapid and substantial progress is made in monochromatic perovskite light-emitting diodes (LEDs), however, challenges remain in achieving white electroluminescence for high-definition display and lighting applications with perovskites as emitters. Here, a proof-of-the-concept configuration is proposed that successfully demonstrates monolithic perovskite/organic hybrid white LEDs (P/O-WLEDs) with a wide color gamut for the first time. In this configuration, pure-green and deep-blue organic emission units are successively superimposed onto a red emission perovskite layer, forming a hybrid emissive system.

Decoding tumors from fibroblast activation protein: A review of the latest diagnostic and therapeutic prospects.

Fibroblast activation protein (FAP), as a molecule closely associated with the tumor microenvironment (TME), has garnered widespread attention in recent years. FAP is a type II transmembrane serine protease primarily expressed in cancer-associated fibroblasts (CAFs), and it plays a significant role in tumor growth, invasion, metastasis, and immune evasion processes. FAP is highly expressed in over 90 % of epithelial cancers, which makes it a satisfactory diagnostic marker on account of its exceptional sensitivity and specificity.

Synergistic Control of Organic Lead Chloride Perovskite Crystallization through the Precursor and Growth Substrate for High-Performance and Stable Transparent Optoelectronics.

Transparent optoelectronics are crucial in modern applications, advancing display technologies in smartphones and smart windows, and supporting high-speed communication systems and advanced sensors. CHNHPbCl (MAPbCl) has garnered significant attention due to its ideal optical bandgap and outstanding optoelectronic performance. However, the fabrication of high-quality MAPbCl thin films faces significant challenges, primarily due to the uncontrolled nucleation process, which results in nonuniform crystallization, poor surface coverage with numerous voids, and high roughness.

Effects of Hand Strength and Walking Speed Combined and in Isolation on the Prediction of Cognitive Decline and Dementia in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis.

Objective: This review aims to further elucidate the relationship between reduced walking speed and grip function and cognitive decline.

Design: Systematic review and meta-analysis.

Settings And Participants: Adults without dementia.

Spiro Units Embedded in the B/N Center for Constructing Highly Efficient Multiple Resonance TADF Emitters.

Departing from conventional molecular design strategies that rely on spiro units merely as peripheral components (side chains, terminal groups, or linkage units), we fully or partially incorporate the rigid 9,9'-spirobi[fluorene] (SF) unit into the boron/nitrogen multiple resonances (B/N-MR) emitting core, thereby successfully developing a series of proof-of-concept isomerized multiple resonance thermally activated delayed fluorescence (MR-TADF) emitters, namely SF-BN1, SF-BN2, SF-BN3, and SF-BN4. Remarkably, these novel emitters exhibit exceptionally narrow full-width at half-maximum (FWHM) values of 15-21 nm in dilute toluene solutions and high photoluminescence quantum yields (PLQYs) of up to 90% in doped films. The corresponding organic light-emitting diode (OLED) based on SF-BN1 achieved high external quantum efficiency (EQE) of up to 29.

High-Temperature-Induced Fused Polycyclic Aromatic Multiple Resonance Emitters Exhibiting Narrowband and Pronounced Red-Shifted Emission.

Synthetic methodology is a fundamental framework for preparing functional materials, significantly advancing their development. Herein, a novel 6π electrocyclization reaction is unexpectedly discovered that promotes further ring closure in materials derived from multi-resonance thermally activated delayed fluorescence (MR-TADF) compounds, known for their narrow emission. By simply raising the reaction temperature, this process significantly red-shifts the emission peak of the target material while effectively narrowing its emissive width and greatly enhancing its optoelectronic performance.

Surface Nanostructure Fabrication by Initiated Chemical Vapor Deposition and Its Combined Technologies.

Initiated chemical vapor deposition (iCVD) is a versatile technique that enables the direct growth of nanostructures and surface modification of such structures. Unlike traditional CVD methods, iCVD operates under mild conditions, allowing for damage-free processing of delicate substrates. It can produce highly uniform polymer layers, with thicknesses ranging from over 15 μm to sub-10 nm, conformally coating intricate geometries.

[Clinical dilemma and indication selection of restoration for permanent tooth defects in adolescents].

Adolescence is defined as a population ranging from ten to nineteen years old. Permanent teeth in adolescents are of critical significance as they are actively involved in mastication, contribute to aesthetic appearance, play a role in pronunciation, and are integral to the growth and development of the stomatognathic system. Specifically, permanent teeth in adolescents comprise those with incomplete root development and those with complete root development but unstable gingival margin positions.

Bifunctional Group Modulation Strategy Enables MR-TADF Electroluminescence Toward BT.2020 Green Light Standard.

Herein, a parallel "bifunctional group" modulation method is proposed to achieve controlled modulation of the emission wavelength and full-width at half-maximum (FWHM) values. As a result, three proof-of-concept emitters, namely DBNDS-TPh, DBNDS-DFPh, and DBNDS-CNPh, are designed and synthesized, with the first functional dibenzo[b,d]thiophene unit concurrently reducing the bandgap and elevate their triplet state energy. A second functional group 1,1':3',1″-triphenyl, and electron acceptors 1,3-difluorobenzene and benzonitrile, respectively, to deepen the HOMO and LUMO levels.

PbS Quantum Dot-Based Optoelectronic Memristors toward Multi-Task Reservoir Computing.

The rise of big data and the internet of things has driven the demand for multimodal sensing and high-efficiency low-latency processing. Inspired by the human sensory system, we present a multifunctional optoelectronic-memristor-based reservoir computing (OM-RC) system by utilizing a CuSCN/PbS quantum dots (QDs) heterojunction. The OM-RC system exhibits volatile and nonlinear responses to electrical signals and wide-spectrum optical stimuli covering ultraviolet, visible, and near-infrared (NIR) regions, enabling multitask processing of dynamic signals.

Comparison of multi-phase contrast-enhanced T1-weighted volumetric interpolated breath-hold examination and fat-suppressed T2-weighted combined with diffusion-weighted magnetic resonance imaging in anal fistula evaluation.

Background: Anal fistula is a common anorectal disorder that significantly diminishes the quality of life for affected patients. Accurate preoperative evaluation of the fistula's traits is essential for customizing surgical strategies, improving patient outcomes, and reducing the likelihood of the disease returning. This study aimed to evaluate the diagnostic accuracy of multi-phase contrast-enhanced fat-suppressed T1-weighted imaging using three-dimensional gradient echo sequence volumetric interpolated breath-hold examination (CE-FS-T1-3D-VIBE) and fat-suppressed T2-weighted imaging combined with diffusion-weighted imaging (FS-T2WI-DWI) sequence in delineating the characteristics of anal fistulas.

Epicatechin-mediated modulation of the Nrf2/HO-1 pathway alleviates senile cerebral ischemic/reperfusion injury.

Excessive reactive oxygen species (ROS) generated during cerebral ischemic reperfusion (CIRI) are crucial for subsequent tissue damage. However, despite the potential benefits of antioxidants reported in clinical applications, few have proven effective in treating CIRI, particularly in the elderly. Epicatechin (EC) is a catechol flavonoid monomer derived from natural tea plants.

Electrical Doping Regulation of Carrier Recombination Enhances the Perovskite Solar Cell Efficiency beyond 28.

With the power conversion efficiency (PCE) of perovskite solar cells (PSCs) exceeding 26.7%, achieving further enhancements in device performance has become a key research focus. Here, we investigate the impact of electrical doping in the perovskite layer using the drift-diffusion equation-based device physics model, coupled with a self-developed equivalent circuit model.

Model-free adaptive consensus design for a class of unknown heterogeneous nonlinear multi-agent systems with packet dropouts.

This paper studies the consensus problem for a class of unknown heterogeneous nonlinear multi-agent systems via a network with random packet dropouts. Based on the dynamic linearization technique, novel model-free adaptive consensus protocols with the data compensation mechanism are designed for both leaderless and leader-following cases. The advantage of this approach is that only neighborhood input and output data of the agents are required in the protocol design.

Regional Functionalization Molecular Design Strategy: A Key to Enhancing the Efficiency of Multi-Resonance OLEDs.

Herein, we propose a regional functionalization molecular design strategy that enables independent control of distinct pivotal parameters through different molecule segments. Three novel multiple resonances thermally activated delayed fluorescence (MR-TADF) emitters A-BN, DA-BN, and A-DBN, have been successfully synthesized by integrating highly rigid and three-dimensional adamantane-containing spirofluorene units into the MR framework. These molecules form two distinctive functional parts: part 1 comprises a boron-nitrogen (BN)-MR framework with adjacent benzene and fluorene units forming a central luminescent core characterized by an exceptionally rigid planar geometry, allowing for narrow FWHM values; part 2 includes peripheral mesitylene, benzene, and adamantyl groups, creating a unique three-dimensional "umbrella-like" conformation to mitigate intermolecular interactions and suppress exciton annihilation.

Highly Horizontal Oriented Tricomponent Exciplex Host with Multiple Reverse Intersystem Crossing Channels for High-Performance Narrowband Electroluminescence and Eye-Protection White Organic Light-Emitting Diodes.

Despite multiple-resonance thermally activated delayed fluorescence (MR-TADF) emitters with small full-width at half maximum are attractive for wide color-gamut display and eye-protection lighting applications, their inefficient reverse intersystem crossing (RISC) process and long exciton lifetime induce serious efficiency roll-off, which significantly limits their development. Herein, a novel device concept of building highly efficient tricomponent exciplex with multiple RISC channels is proposed to realize reduced exciton quenching and enhanced upconversion of nonradiative triplet excitons, and subsequently used as a host for high-performance MR-TADF organic light-emitting diodes (OLEDs). Compared with traditional binary exciplex, the tricomponent exciplex exhibits obviously improved photoluminescence quantum yield, emitting dipole orientation and RISC rate constant, and a record-breaking external quantum efficiency (EQE) of 30.

Optimizing the energy level alignment for achieving record-breaking efficiency in hot exciton deep red OLEDs.

To effectively compete with the quenching process in long-wavelength regions like deep red (DR) and near-infrared (NIR), rapid radiative decay is urgently needed to address the challenges posed by the "energy gap law". Herein, we confirmed that it is crucial for hot exciton emitters to attain a narrow energy gap (Δ) between the lowest singlet excited (S) state and second triplet excited (T) state, while ensuring that T slightly exceeds S in the energy level. Two proofs-of-concept of hot exciton DR emitters, namely αT-IPD and βT-IPD, were successfully designed and synthesized by coupling electron-acceptors ,-diphenylnaphthalen-2-amine (αTPA) and ,-diphenylnaphthalen-1-amine (βTPA) with an electron-withdrawing unit 5-(4-(-butyl) phenyl)-5H-pyrazino[2,3-]indole-2,3-dicarbonitrile (IPD).

Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake.

Accumulating evidence has demonstrated that apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs; MSC-apoVs) are vital for bone regeneration, and possess superior capabilities compared to MSCs and other extracellular vesicles derived from MSCs (such as exosomes). The osteoinductive effect of MSC-apoVs is attributed to their diverse contents, especially enriched proteins or microRNAs (miRNAs). To optimize their osteoinduction activity, it is necessary to determine the unique cargo profiles of MSC-apoVs.

Safety and Pharmacokinetic Assessment of the FIC CLDN18.2/4-1BB Bispecific Antibody in Rhesus Monkeys.

Gastric cancer is one of the most common cancers worldwide, particularly in China, with over half a million new cases and over 400 thousand deaths in 2022. Zolbetuximab, a first-in-class investigational monoclonal antibody (mAb) targeting tumor-associated antigen CLDN18.2 which is highly expressed on gastric cancer cells, was recently reported to meet the primary endpoint in Phase III trial as first-line treatment in CLDN18.

Phase-Pure α-FAPbI Perovskite Solar Cells via Activating Lead-Iodine Frameworks.

Narrow bandgap cubic formamidine perovskite (α-FAPbI) is widely studied for its potential to achieve record‑breaking efficiency. However, its high preparation difficulty caused by lattice instability is criticized. A popular strategy for stabilizing the α-FAPbI lattice is to replace intrinsic FA or I with smaller ions of MA, Cs, Rb, and Br, whereas this generally leads to broadened optical bandgap and phase separation.

Surgical Essentials and 2-Year Follow-Up Results of Channel Repair in Endoscopic Transcorporeal Discectomy for Cervical Disc Herniation.

Objective: To evaluate long-term outcomes and surgical essentials of channel repair in endoscopic transcorporeal discectomy for cervical disc herniation.

Methods: From October 2019 to March 2020, 24 patients with cervical disc herniation underwent channel repair after percutaneous full-endoscopic anterior transcorporeal cervical discectomy. Five interventions were performed at C3-C4, 11 were performed at C4-C5, and 8 were performed at C5-C6.

Digital measurement method for comparing the absolute marginal discrepancy of three-unit ceramic fixed dental prostheses fabricated using conventional and digital technologies.

Background: In clinical practice, control of the marginal fit of fixed dental prostheses is hindered by evaluation method, which needs to be further improved to increase its clinical applicability. This study aimed to quantitatively analyze the absolute marginal discrepancy of three-unit ceramic fixed dental prostheses fabricated by conventional and digital technologies using a digital measurement method based on the digital impression technology and open source software.

Methods: A digital workflow and the conventional impression combined with the lost-wax heat-pressed technique were adopted to separately fabricate 10 glass ceramic fixed dental prostheses.