Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Intermittent hypoxia is the main pathophysiological cause of the obstructive sleep apnea syndrome. Astragalus shows improvement of spatial learning and memory abilities under intermittent hypoxia. Our study aimed to investigate the protective effect of astragalus against intermittent hypoxia induced-hippocampal neurons impairment in rats and lay the theoretical foundation for the sleep apnea improvement in cognitive function by astragalus.
Methods: Male Wistar rats were divided into 4 groups: blank control group, normoxia group, intermittent hypoxia group and astragalus treated intermittent hypoxia group. After 6-week treatment, apoptosis of neurons was evaluated by terminal deoxynucleotidyl-transferase-mediated dUTP nick end-labeling (TUNEL) assay. Furthermore, the expression of HIF-1a was detected by real-time reverse transcription polymerase chain reaction (RT-PCR) at the mRNA level as well as by immunohistochemistry (IHC) and Western blotting at the protein level.
Results: HPLC analysis indicated that astragaloside IV, astragaloside II and astragaloside I were the main compounds in astragals extract. Astragalus extract reduced the apoptosis of hippocampal neurons (P < 0.05) and decreased the expression of HIF-1a at both the mRNA and protein levels in hippocampus compared with non-treated groups (P < 0.05).
Conclusion: Astragalus protects against intermittent hypoxia-induced hippocampal neurons impairment in rats.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Brain functional alterations in type 2 diabetes with obstructive sleep apnea patients: A multicenter resting-state fMRI study.
Sleep Med
August 2025
Department of Radiology Imaging Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, PR China. Electronic address:
Objective: This multicenter study aimed to investigate resting-state brain functional alterations in patients with type 2 diabetes mellitus (T2DM) comorbid with obstructive sleep apnea (OSA), and to elucidate the underlying neural mechanisms.
Methods: A total of 139 participants were enrolled from two centers, including 48 healthy controls (HCs), 46 T2DM patients, and 45 T2DM with OSA patients. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to assess brain function using degree centrality (DC), amplitude of low-frequency fluctuation (ALFF), and seed-based functional connectivity (FC).
Aortic Dissection With Pseudoaneurysm Formation Masquerading as Pulmonary Embolism After Transcatheter Aortic Valve Replacement.
Catheter Cardiovasc Interv
September 2025
Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Transcatheter aortic valve replacement (TAVR) is a commonly performed procedure for the treatment of severe aortic stenosis. While it is generally considered a low-risk procedure, one of the rare potentially life-threatening complications includes aortic dissection. We report the case of a 75-year-old immunocompromised female who presented 2 weeks post-TAVR with persistent and worsening dyspnea, intermittent chest pain, and hypoxia.
View Article and Find Full Text PDFExosomes in obstructive sleep apnea-related diseases.
Chin Med J (Engl)
September 2025
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Obstructive sleep apnea (OSA) is a global public health concern characterized by repeated upper airway collapse during sleep. Research indicates that OSA is a risk factor for the development of various diseases, including cardiovascular disease, metabolic disorders, respiratory diseases, neurodegenerative diseases, and cancer. Exosomes, extracellular vesicles released by most cell types, play a key role in intercellular communication by transporting their contents-such as microRNA, messenger RNA, DNA, proteins, and lipids-to target cells.
View Article and Find Full Text PDFExosomal LncRNA MALAT1 Derived from Hepatocytes in Nonalcoholic Fatty Liver Disease Regulates the miR-579-3p/Keap1/Nrf2 Pathway to Exacerbate Obstructive Sleep Apnea Syndrome.
Mol Biotechnol
September 2025
Hypertension Center, Yan'an Hospital Affiliated to Kunming Medical University, Kunming Technical Diagnosis and Treatment Center for Refractory Hypertension, No.245 Renmin East Road, Kunming, 650000, Yunnan, China.
Background And Objective: Obstructive sleep apnea syndrome (OSAS) is a common sleep breathing disorder, and nonalcoholic fatty liver disease (NAFLD) may affect OSAS. This study aimed to explore the influence of exosomes (Exos) derived from liver cells in NAFLD on the progression of OSAS and the underlying molecular mechanisms.
Methods: C57BL/6J mice were exposed to chronic intermittent hypoxia (CIH) to establish an OSAS animal model, and SH-SY5Y cells treated with CIH were used as the in vitro cellular model.
Hypoxia Disrupted Serotonin Levels in the Prefrontal Cortex and Striatum, Leading to Depression-like Behavior.
Biology (Basel)
July 2025
Department of Physiology, School of Medicine, Ankara University, Ankara 06230, Türkiye.
Hypoxia can adversely affect multiple organ systems. This study investigated the impact of intermittent hypoxia on serotonin levels and depression-like behaviors across distinct neuroanatomical regions. Sixteen adult female Wistar albino rats were divided into two groups: control ( = 8) and hypoxia ( = 8).
View Article and Find Full Text PDF