Highly luminescent quantum dots functionalized and their conjugation with IgG.

J Colloid Interface Sci

School of Materials Science and Engineering, University of Jinan, 250022 Jinan, PR China.

Published: May 2010


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Article Abstract

A sol-gel approach including partially removing capping agents, depositing SiO(2) monomers, and growing a SiO(2) shell was developed to generate a bio-compatible functionalization on CdTe quantum dots (QDs). The QDs retained their high photoluminescence (PL) efficiency after coating with a SiO(2) shell (22.5%) by controlling the surface state of the QDs to decrease PL degradation during a sol-gel preparation. Furthermore, the CdTe QDs with a SiO(2) shell were conjugated with IgG using 3-sulfo-N-hydroxysuccinimide or streptavidin-maleimide as linkers. The biotin-streptavidin linker resulted in a high PL efficiency retained (only ~23% lower than the initial value of the QDs), which is crucial for bio-applications.

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http://dx.doi.org/10.1016/j.jcis.2010.01.072DOI Listing

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