The impact of exercise self-efficacy on depression in firefighters: mediating effect of basic psychological needs and moderating effect of perceived social support.

Background: Firefighters are exposed to high-stress work environments and are prone to depression, which has a significant impact on their professional performance and quality of life. Although exercise self-efficacy has been suggested to potentially influence psychological wellbeing, its mechanism of action on firefighters' depression has not been clarified.

Methods: This study investigated the relationship between exercise self-efficacy and depression in firefighters and examined the mediating role of basic psychological needs and the moderating role of perceived social support.

Rumination and psychological resilience in Chinese civil aviation flight students: the chain mediating role of proactive coping and generalized anxiety disorder.

Background: As the focus of aviation safety shifts from technology to human factors, the central role of psychological resilience in flight safety has become increasingly prominent. However, the internal mechanism of how rumination affects psychological resilience, particularly the chain mediating effect of proactive coping and generalized anxiety, has not been thoroughly explored in high-stress populations.

Methods: Employing a cross-sectional design, 1,235 flight students from the Civil Aviation Flight University of China were surveyed using the Ruminative Response Scale (RRS), Connor-Davidson Resilience Scale (CD-RISC), Simplified Coping Style Questionnaire (SCSQ), and Generalized Anxiety Disorder Scale (GAD-7) to gather data.

The role of the Steroidogenesis-Associated gene cyp11a in regulating gonadal development in Hyriopsis cumingii.

The Cyp11a gene is essential for steroid hormone synthesis, which is closely associated with gonadal development. To explore the role of Cyp11a in the gonadal development of Hyriopsis cumingii, we cloned the 2951 bp H. cumingii Cyp11a gene (Hccyp11a), which includes a 2376 bp open reading frame (ORF) encoding 791 amino acids.

Gut microbiota: emerging biomarkers and potential therapeutics for premature ovarian failure.

Premature ovarian failure is a prevalent gynecological endocrine disorder with an increasing incidence rate each year, impacting women's physical and mental health. The causes of POF are poorly understood, but genetic, immune, iatrogenic, environmental, and psychological factors are key contributors. Clinically, POF manifests as oligomenorrhea, amenorrhea, elevated follicle-stimulating hormone (FSH) levels, and decreased estrogen levels, leading to infertility in women.

Undiagnosed placenta percreta complicated by bowel injury and puerperal infection: a case report.

Background: The refractory obstetric hemorrhage occurring as a result of placenta percreta has been a major cause of maternal mortality. The incidence of placenta accreta spectrum (PAS) disorders has significantly increased recently, with the increasing frequency of cesarean sections and other procedures such as myomectomy, which contribute to uterine scarring. Placenta percreta resulting in uterointestinal injury, however, is far less common.

Advances in the interrelated nature of vaginal microecology, HPV infection, and cervical lesions.

Vaginal microecology serves as a crucial defense mechanism in women's reproductive health. It encompasses vaginal anatomy, microbial flora, endocrine regulation, and immune responses. species dominate this ecosystem, maintaining a dynamic balance essential for vaginal health.

Rejuvenation of Tumor-Specific T Cells via Ultrahigh DAR Antibody-Polymeric Imidazoquinoline Complexes: Coordinated Targeting of PDL1 and Efficient TLR7/8 Activation in Intratumoral Dendritic Cells.

Intratumoral dendritic cells (DCs) are pivotal in tumor treatment due to their immature and pro-tumoral state induced by the tumor microenvironment. Clinically, these immature DCs correlate with disease progression and recurrence, adversely affecting prognosis. Activation of DCs by the TLR7/8 agonist imidazoquinoline (IMDQ) has yielded promising results, but they are limited by systemic inflammation risks, and high programmed death ligand 1 (PDL1) expression on DCs impedes CD8 T cell activity.

Polymeric Multivalent Fc Binding Peptides-Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA-4.

Dual Opdivo plus Yervoy immunotherapy, targeting the immune checkpoints PD1 and CTLA-4, is successful in clinical use. However, it is associated with a high incidence of adverse events, and its therapeutic efficacy needs improving. In this study, polymeric multivalent Fc-binding peptides (PLG-Fc-III-4C) are employed to fabricate a bispecific antibody (PD1/CTLA-4 BsAb) to potentiate dual immunotherapy targeting PD1 and CTLA-4.

Friend or foe: The role of stress granule in neurodegenerative disease.

Stress granules (SGs) are dynamic membraneless organelles that form in response to cellular stress. SGs are predominantly composed of RNA and RNA-binding proteins that assemble through liquid-liquid phase separation. Although the formation of SGs is considered a transient and protective response to cellular stress, their dysregulation or persistence may contribute to various neurodegenerative diseases.

Hyaluronic acid modified extracellular vesicles targeting hepatic stellate cells to attenuate hepatic fibrosis.

Rationale: Transforming growth factor-beta1 (TGF-β1) plays a pivotal role in promoting hepatic fibrosis, pirfenidone (PFD) could inhibit TGF-β1 signaling pathway to alleviate hepatic stellate cells (HSC) activation mediated hepatic fibrosis. The targeting delivery strategy of PFD to hepatic stellate cells is a challenge. Extracellular vesicles (EVs), cell-derived membranous particles are intraluminal nano-vesicles that play a vital role in intercellular communication, they also be considered as an ideal nano-carrier.

Relationship between perceived social support and mental health among Chinese college football athletes: a moderated mediation model.

Previous researches have confirmed that perceived social support has a profound effect on individuals' mental health. However, the effects and potential mechanisms of perceived social support on mental health of college athletes are still largely unknown, especially during and after the COVID-19 pandemic. Thus, the aim of this study was to explore the relationship between perceived social support and mental health in college football athletes, and to evaluate whether hopelessness and psychological pressure affected this relationship.

Study on the Role of Mitophagy Receptor PHB2 in Doubly Uniparental Inheritance of Hyriopsis cumingii.

In bivalves, the heterogeneity of mitochondrial DNA and its unique mode of transmission have been the focus of attention, which is called doubly uniparental inheritance (DUI). Prohibitin-2 (phb2) is a mitochondrial inner membrane protein that is a key mitophagy receptor for parental mitochondrial removal. Hyriopsis cumingii is a freshwater bivalve in China, the full-length cDNA of H.

Post-Traumatic Stress Disorder and Mental Health in Chinese College Athletes during and after the COVID-19 Pandemic: The Multiple Mediating Effects of Basic Psychological Needs and Generalized Anxiety Disorder.

Psychological issues have a complex and multidimensional impact on a college athlete's training and performance. As the reserve talent of competitive sports, it is very important to investigate the psychological health of athletes. This study aims to explore the association between generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), basic psychological needs (BPN), and mental health (MH) among Chinese college athletes.

The protective role of vitamin C on intestinal damage induced by high-dose glycinin in juvenile Rhynchocypris lagowskii Dybowski.

This study was to evaluate the mitigative effects of vitamin C (VC) on growth inhibition and intestinal damage induced by glycinin in juvenile Rhynchocypris lagowskii Dybowski. 270 healthy juvenile Rhynchocypris lagowskii Dybowski (4.65 ± 0.

The Mediating Role of Perceived Stress and Academic Procrastination between Physical Activity and Depressive Symptoms among Chinese College Students during the COVID-19 Pandemic.

Depressive symptoms, a prevalent mood illness, significantly harm college students' physical and mental health. Individuals have experienced some degree of psychological harm as a result of the COVID-19 pandemic. Taking this into account, the purpose of this study was to investigate the relationship between physical activity (PA) and depressive symptoms among college students during the COVID-19 pandemic, as well as the mediating roles of perceived stress and academic procrastination.

The Association between Occupational Stress and Mental Health among Chinese Soccer Referees in the Early Stage of Reopening Soccer Matches during the COVID-19 Pandemic Outbreak: A Moderated Mediation Model.

Background: The sudden and unpredictable changes caused by the COVID-19 pandemic are a serious threat to the occupational stress and mental health of referees worldwide, which has not attracted widespread attention. The mental health of football referees has a certain influence on their job satisfaction or the accuracy of judgments.

Methods: This study constructed a moderated mediation model to explore the buffer factors between occupational stress and mental health in Chinese soccer referees in the early stage of reopening soccer matches during the COVID-19 pandemic outbreak.

The effect of the perceived social support on mental health of Chinese college soccer players during the COVID-19 lockdown: The chain mediating role of athlete burnout and hopelessness.

The isolation and blockade during the COVID-19 pandemic have a great impact on the mental health of Chinese college soccer players. This study aimed to explore the effect of perceived social support on mental health of college soccer players, as well as the mediating role of athlete burnout and hopelessness during the COVID-19 lockdown. Based on a sample of 674 college soccer players from several universities in China, the study used the Perceived Social Support Scale (PSSS), Kessler Psychological Distress Scale (K10), Athlete Burnout Questionnaire (ABQ) and Beck Hopelessness Scale (BHS).

Identification and Functional Analysis of in .

() is an important regulator of the p38 mitogen-activated protein kinase (p38 MAPK) pathway, which is involved in a plethora of cellular processes concluding the development of gamete cells in meiosis and resisting pathogenic bacterial infestation. is a significant mussel resource in China and a good material for pearl breeding. To explore the role of in was identified and cloned, whose full-length cDNA was 1568 bp, including 87 bp in 5' UTR, 398 bp in 3' UTR, and 1083 bp in the open reading frame (ORF) region, encoding 360 amino acids.

Taurine can improve intestinal function and integrity in juvenile Rhynchocypris lagowskii Dybowski fed high-dose glycinin.

The present study evaluated the protective effect and the regulatory mechanism of taurine on growth inhibition and intestinal damage induced by glycinin in juvenile Rhynchocypris lagowskii Dybowski. The control diets had no glycinin and taurine, the glycinin diets contained only 80 g/kg glycinin, and the glycinin + taurine diets contained 80 g/kg glycinin+10 g/kg taurine. Juvenile Rhynchocypris lagowskii Dybowski (4.

Relationship Between Physical Activity, Parental Psychological Control, Basic Psychological Needs, Anxiety, and Mental Health in Chinese Engineering College Students During the COVID-19 Pandemic.

The issue of mental health among college students is of increasing concern during the COVID-19 outbreak. Since course characteristics of engineering college students determine the particularities of their mental health, the specific objectives of this study were: (1) to analyze the relationship between physical activity, parental psychological control, basic psychological needs, anxiety, and mental health in Chinese engineering college students during COVID-19 pandemic; and (2) to examine the mediation effect of anxiety between the relationship of basic psychological needs and mental health. A cross-sectional study was conducted among several universities in Shandong Province, China.

A deep learning approach for medical waste classification.

As the demand for health grows, the increase in medical waste generation is gradually outstripping the load. In this paper, we propose a deep learning approach for identification and classification of medical waste. Deep learning is currently the most popular technique in image classification, but its need for large amounts of data limits its usage.