[Guihuang Formula for type III prostatitis with damp-heat stasis syndrome in the essence chamber: A clinical trial].

Objective: To investigate the efficacy and safety of Guihuang Formula (GHF) in the treatment of type III prostatitis with the syndrome of damp-heat stasis in the essence chamber.

Methods: This study included 120 cases of type III prostatitis with damp-heat stasis syndrome in the essence chamber, which were randomly and equally divided into a GHF and a control group, the former treated with GHF and the latter with Tamsulosin Hydrochloride Sustained-Release Capsules, both for 6 successive weeks. We followed up the patients for 4 weeks, recorded the NIH-CPSI, TCM symptom scores, and results of prostatic fluid routine, blood and urine routine, liver and kidney function and electrocardiogram examinations, and compared them between the two groups of patients before and after treatment.

Dissecting the roles of Taiman in pupation and female reproduction of Helicoverpa armigera.

In insects, metamorphosis and reproduction are coordinated by juvenile hormone (JH) and 20-hydroxyecdysone (20E). A transcription factor Taiman (Tai) serves as a coactivator of the functional 20E receptor and heterodimerizes with JH receptor Methoprene-tolerant (Met) to form an active receptor complex, encoding a key modulator of JH and 20E signaling pathways. However, direct evidence for the participation of Tai in metamorphic actions and vitellogenesis is quite limited.

Targeting Decidual Macrophage Polarization through JNK Signaling Pathway Inhibition Alleviates Adverse Pregnancy Outcomes in Early Spontaneous Abortion.

Early spontaneous abortion (ESA) is associated with abnormal decidual macrophage polarization at the maternal-fetal interface. While JNK signaling is recognized in implantation and immunomodulation, its contribution to decidual macrophage polarization in the ESA is poorly understood. The decidual tissues of ESA patients were collected to detect the polarization status and the expression of JNK1/2 and p-JNK in decidual macrophages (DMs) through flow cytometry assessment.

[Rapid and simultaneous determination of 11 ergot alkaloids in cereals and their products by ultra performance liquid chromatography-tandem mass spectrometry combined with Captiva EMR-Lipid column purification].

Ergot alkaloids (EAs) are mycotoxins produced by and are present in cereals and their products; their residues pose significant threats to human health through food consumption, resulting in ergotism and sickness. Herein, a sensitive and rapid method for the determination of 11 EAs in cereals and their products using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) were developed. Eleven EAs were extracted with 20 mL acetonitrile-200 mg/L ammonium acetate solution (80∶20, v/v) for 15 min using the vortex shock method followed by 15 min of ultrasonication.

Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice.

Background: Major depressive disorder is a significant global cause of disability, particularly among adolescents. The dopamine system and nearby neuroinflammation, crucial for regulating mood and processing rewards, are central to the frontostriatal circuit, which is linked to depression. This study aimed to investigate the effect of post-weaning isolation (PWI) on depression in adolescent mice, with a focus on exploring the involvement of microglia and dopamine D1 receptor (D1R) in the frontostriatal circuit due to their known links with mood disorders.

[Treatment of chronic prostatitis with Xiongji Formula based on the concept of "brain-heart-kidney-essence chamber" axis of medication].

Chronic prostatitis is a process of kidney deficiency and blood stasis mixed with various pathological factors involving the essence chamber, which is manifested as kidney deficiency and blood stasis. Based on the concept of the "brain-heart-kidney-essence chamber" axis of medication, Xiongji Formula is applied to the treatment of chronic prostatitis, due to its "simultaneous holistic and local action" and effects of tonifying the kidney yang and assisting the systemic yang, acting on the brain, heart and kidney as a whole, and meanwhile activating blood circulation, eliminating blood stasis and restoring the function of the essence chamber. This paper discusses the etiology and pathogenesis of chronic prostatitis with kidney deficiency and blood stasis in Chinese medicine, expounds the significance of "brain-heart-kidney-essence chamber" axis of medication, and explores the specific value and clinical application of Xiongji Formula.

Singular dielectric nanolaser with atomic-scale field localization.

Compressing the optical field to the atomic scale opens up possibilities for directly observing individual molecules, offering innovative imaging and research tools for both physical and life sciences. However, the diffraction limit imposes a fundamental constraint on how much the optical field can be compressed, based on the achievable photon momentum. In contrast to dielectric structures, plasmonics offer superior field confinement by coupling the light field with the oscillations of free electrons in metals.

Dipole Moment Influences the Reversibility and Corrosion of Lithium Metal Anodes.

Lithium metal batteries (LMBs) must have both long cycle life and calendar life to be commercially viable. However, "trial and error" methodologies remain prevalent in contemporary research endeavors to identify favorable electrolytes. Here, a guiding principle for the selection of solvents for LMBs is proposed, which aims to achieve high Coulombic efficiency while minimizing the corrosion.

[Discussion on the biological basis of chronic prostatitis based on the "brain-centre-kidney-vessel" axis].

Chronic prostatitis is a common disease in male clinics. The theory of "brain-centre-kidney-vessel" axisis based on the basic theories of traditional Chinese medicine, the pathogenesis of modern men's diseases, and the theory of traditional Chinese medicine in men's medicine proposed by clinical practice. It takes the "brain-heart-kidney-vessel" axis as the entry point, the use of the vessel as the core pathogenesis, the meridians as the link, and the dysfunction of the brain, heart, and kidneys as the important conditions, and proposes that the biological basis between chronic prostatitis and the "brain-heart-kidney-vessel" axis is related to neurological, endocrine, and immunological disorders, as well as the biological basis of the "brain-heart-kidney-vessel" axis.

Genome-wide characterization of SmZHD gene family and the role of SmZHD12 in regulating anthocyanin biosynthesis in eggplant (Solanum melongena L.).

SmZHDs was highly expressed in anthocyanin-rich parts of eggplant. SmZHD12 can activate the expression of SmCHS, SmANS, SmDFR and SmF3H. Overexpression of SmZHD12 promotes anthocyanin biosynthesis in Arabidopsis.

Reconfigurable moiré nanolaser arrays with phase synchronization.

Miniaturized lasers play a central role in the infrastructure of modern information society. The breakthrough in laser miniaturization beyond the wavelength scale has opened up new opportunities for a wide range of applications, as well as for investigating light-matter interactions in extreme-optical-field localization and lasing-mode engineering. An ultimate objective of microscale laser research is to develop reconfigurable coherent nanolaser arrays that can simultaneously enhance information capacity and functionality.

[Characteristics of sympathetic skin response in children with Guillain-Barré syndrome].

Objectives: To explore the value of sympathetic skin response (SSR) in the early diagnosis and prognostic evaluation of Guillain-Barre syndrome (GBS) in children.

Methods: A retrospective analysis was conducted on the clinical data of 25 children with GBS who were diagnosed from October 2018 to November 2022, and 30 children who were diagnosed with Tourette's syndrome during the same period were selected as the control group. The characteristics of SSR were compared between the two groups, and the association of SSR with autonomic dysfunction (AD), disease severity, and prognosis was analyzed.

Identification and immuno-infiltration analysis of cuproptosis regulators in human spermatogenic dysfunction.

Cuproptosis seems to promote the progression of diverse diseases. Hence, we explored the cuproptosis regulators in human spermatogenic dysfunction (SD), analyzed the condition of immune cell infiltration, and constructed a predictive model. Two microarray datasets (GSE4797 and GSE45885) related to male infertility (MI) patients with SD were downloaded from the Gene Expression Omnibus (GEO) database.

[Simultaneous determination of seven quaternary ammonium compounds in frozen food by ultra performance liquid chromatography-tandem mass spectrometry combined with modified QuEChERS method].

Quaternary ammonium compounds (QACs) are a class of cationic surfactants that can be used as the main active ingredient of disinfectants. The increased use of QACs is concerning as exposure from inhalation or ingestion to these compounds that has been associated with adverse effects on the reproductive and respiratory systems. Humans are exposed to QACs primarily by food consumption and inhalation of air.

Understanding the Origin and Evolution of Tea (Camellia sinensis [L.]): Genomic Advances in Tea.

Tea, which is processed by the tender shoots or leaves of tea plant (Camellia sinensis), is one of the most popular nonalcoholic beverages in the world and has numerous health benefits for humans. Along with new progress in biotechnologies, the refined chromosome-scale reference tea genomes have been achieved, which facilitates great promise for the understanding of fundamental genomic architecture and evolution of the tea plants. Here, we summarize recent achievements in genome sequencing in tea plants and review the new progress in origin and evolution of tea plants by population sequencing analysis.

Relationship between pyroptosis-mediated inflammation and the pathogenesis of prostate disease.

The largest solid organ of the male genitalia, the prostate gland, is comprised of a variety of cells such as prostate epithelial cells, smooth muscle cells, fibroblasts, and endothelial cells. Prostate diseases, especially prostate cancer and prostatitis, are often accompanied by acute/chronic inflammatory responses or even cell death. Pyroptosis, a cell death distinct from necrosis and apoptosis, which mediate inflammation may be closely associated with the development of prostate disease.

Twisted lattice nanocavity with theoretical quality factor exceeding 200 billion.

Simultaneous localization of light to extreme spatial and spectral scales is of high importance for testing fundamental physics and various applications. However, there is a longstanding trade-off between localizing a light field in space and in frequency. Here we discover a new class of twisted lattice nanocavities based on mode locking in momentum space.

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study.

Background: Triglyceride-glucose (TyG) index, a novel surrogate marker of insulin resistance, has been demonstrated to be significantly associated with cardiovascular disease. It remains indistinct regarding the association between TyG index and non-culprit coronary plaque characteristics in patients following acute coronary syndrome (ACS).

Methods: The present study retrospectively recruited patients who were diagnosed with ACS and underwent non-culprit optical coherence tomography (OCT) examination.

Visceral Adiposity Index Plays an Important Role in Prognostic Prediction in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome and Type 2 Diabetes Mellitus Undergoing Percutaneous Coronary Intervention.

Visceral adiposity index (VAI), a surrogate marker of adiposity and insulin resistance, has been demonstrated to be significantly related to cardiovascular disease. It remains indistinct whether VAI predicts adverse prognosis after percutaneous coronary intervention (PCI) for patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and type 2 diabetes mellitus (T2DM). A total of 798 participants who met the enrollment criteria were finally brought into this study.

Comparison of various insulin resistance surrogates on prognostic prediction and stratification following percutaneous coronary intervention in patients with and without type 2 diabetes mellitus.

Background: Insulin resistance (IR), evaluation of which is difficult and complex, is closely associated with cardiovascular disease. Recently, various IR surrogates have been proposed and proved to be highly correlated with IR assessed by the gold standard. It remains indistinct whether different IR surrogates perform equivalently on prognostic prediction and stratification following percutaneous coronary intervention (PCI) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients with and without type 2 diabetes mellitus (T2DM).

Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice.

Adult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g.

Pancreas-Brain Crosstalk.

The neural regulation of glucose homeostasis in normal and challenged conditions involves the modulation of pancreatic islet-cell function. Compromising the pancreas innervation causes islet autoimmunity in type 1 diabetes and islet cell dysfunction in type 2 diabetes. However, despite the richly innervated nature of the pancreas, islet innervation remains ill-defined.

Antioxidant Effects and Phytochemical Properties of Seven Taiwanese Species Extracts.

In the present investigation, we compared the radical-scavenging activities and phenolic contents of seven Taiwanese species with a spectrophotometric method. We further analyzed their phytochemical profiles with high-performance liquid chromatography-photodiode array detection (HPLC-DAD). We found that the flower part of var.