Geometric phase amplification in a clock interferometer for enhanced metrology.

High-precision measurements are crucial for testing the fundamental laws of nature and advancing the technological frontier. Clock interferometry, where particles with an internal clock are coherently split and recombined along two spatial paths, has sparked interest due to its fundamental implications, especially at the intersection of quantum mechanics and general relativity. Here, we demonstrate that a clock interferometer provides metrological improvement compared to its technical noise-limited counterpart using a single internal quantum state.

Improved YOLOv8-Based Method for the Carapace Keypoint Detection and Size Measurement of Chinese Mitten Crabs.

The carapace size of the Chinese mitten crab () is a vital indicator for assessing the growth performance of crabs. However, measuring the carapace sizes of Chinese mitten crabs remains challenging due to environmental complexity, species-specific behavioral patterns, and the current limitations of data acquisition methods characterized by labor-intensive manual measurements and subjective empirical judgments. Our study proposes an automated carapace dimension-measuring method integrating enhanced computer vision techniques to address the above challenges.

Metabolites from YMF3.00690 Against .

The strains in spp. have the potential to control plant-parasitic nematodes. In our experiment, YMF3.

Immobilization of Multivalent Titanium Cations on Magnetic Composite Microspheres for Highly Efficient DNA Extraction and Amplification.

Magnetic-assisted DNA testing technology has attracted much attention in genetics, clinical diagnostics, environmental microbiology, and molecular biology. However, achieving satisfying DNA adsorption and desorption efficiency in real samples is still a big challenge. In this paper, a new kind of high-quality magnetic composite microsphere of MM@PGMA-PA-Ti was designed and prepared for DNA extraction and detection based on the strong interaction of Ti and phosphate groups.

Visualization of a Machine Learning Framework toward Highly Sensitive Qualitative Analysis by SERS.

Surface-enhanced Raman spectroscopy (SERS), providing near-single-molecule-level fingerprint information, is a powerful tool for the trace analysis of a target in a complicated matrix and is especially facilitated by the development of modern machine learning algorithms. However, both the high demand of mass data and the low interpretability of the mysterious black-box operation significantly limit the well-trained model to real systems in practical applications. Aiming at these two issues, we constructed a novel machine learning algorithm-based framework (Vis-CAD), integrating visual random forest, characteristic amplifier, and data augmentation.

Development of shipboard automatic flow injection analysis-Surface-enhanced Raman spectroscopy instrument toward onsite detection of trace polycyclic aromatic hydrocarbons in water environment.

The qualitative and quantitative analysis of polycyclic aromatic hydrocarbons (PAHs) has been important for the environmental control of persistent organic pollutants for decades. Considering the potential risk of deterioration, degradation, and external pollution during transportation, the development of rapid and onsite detection of trace PAHs is in demand. Here, taking the advantage of high sensitivity of surface-enhanced Raman spectroscopy (SERS), we developed a shipboard instrument by combining a portable Raman instrument and a flow injection device, integrating the sample pretreatment and target detection step by step.

Developing a Peak Extraction and Retention (PEER) Algorithm for Improving the Temporal Resolution of Raman Spectroscopy.

In spectroscopic analysis, push-to-the-limit sensitivity is one of the important topics, particularly when facing the qualitative and quantitative analyses of the trace target. Normally, the effective recognition and extraction of weak signals are the first key steps, for which there has been considerable effort in developing various denoising algorithms for decades. Nevertheless, the lower the signal-to-noise ratio (SNR), the greater the deviation of the peak height and shape during the denoising process.

Realization of a complete Stern-Gerlach interferometer: Toward a test of quantum gravity.

The Stern-Gerlach effect, found a century ago, has become a paradigm of quantum mechanics. Unexpectedly, until recently, there has been little evidence that the original scheme with freely propagating atoms exposed to gradients from macroscopic magnets is a fully coherent quantum process. Several theoretical studies have explained why a Stern-Gerlach interferometer is a formidable challenge.

Single-Handed Double Helix and Spiral Platelet Formed by Racemate of Dissymmetric Cages.

Spontaneous deracemization has been used to separate homochiral domains from the racemic system. However, homochirality can only be referred to when the scales of these domains and systems are specified. To clarify this, we report self-assembly of racemates of dissymmetric cages DC-1 with a cone-shape propeller geometry, forming a centrosymmetric columnar crystalline phase (racemic at crystallographic level).

Homozygosity mapping and next generation sequencing for the genetic diagnosis of hereditary ataxia and spastic paraplegia in consanguineous families.

Introduction: Genetic inheritance plays key roles in patients with ataxia and/or spastic paraplegia in consanguineous families. This study aims to clarify the genetic spectrum of patients with autosomal recessive hereditary ataxia and spastic paraplegias (AR-HA/HSPs) in consanguineous families.

Methods: A total of 36 AR-HA/HSPs consanguineous pedigrees from China were recruited into this study.

Trace detection of polycyclic aromatic hydrocarbons in environmental waters by SERS.

Polycyclic aromatic hydrocarbons (PAHs) are among the most hazardous pollutants and have attracted significant attention in the last decades. Up to now, rapid and on-site trace detection of PAHs remains a challenging issue. Here, taking advantage of the high sensitivity and reliable qualification of Surface-enhanced Raman Spectroscopy (SERS), we firstly carried out trace analyses of 16 typical PAHs in water at concentrations as low as 100-0.

An experimental test of the geodesic rule proposition for the noncyclic geometric phase.

The geometric phase due to the evolution of the Hamiltonian is a central concept in quantum physics and may become advantageous for quantum technology. In noncyclic evolutions, a proposition relates the geometric phase to the area bounded by the phase-space trajectory and the shortest geodesic connecting its end points. The experimental demonstration of this geodesic rule proposition in different systems is of great interest, especially due to the potential use in quantum technology.

BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells.

Breast cancer is the leading cause of cancer-related deaths in women; however, its underlying etiology remains largely unknown. In this study, we systematically analyzed breast cancer tissues using comprehensive iTRAQ labeled quantitative proteomics, identifying 841 differentially expressed proteins (474 and 367 significantly over- and under-expressed, respectively), which were annotated by protein domain analysis. All the heat shock proteins identified were upregulated in breast cancer tissues; Hsp90 upregulation was also validated by RT-qPCR and immunohistochemistry, and high Hsp90 protein levels correlated with poorer survival.

CFTR interacts with Hsp90 and regulates the phosphorylation of AKT and ERK1/2 in colorectal cancer cells.

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF cells and tissues exhibit various mitochondrial abnormalities. However, the underlying molecular mechanisms remain elusive.

JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression.

Most traditional cytotoxic chemotherapeutic agents have poor aqueous solubility and significant toxicity. Hence, there is a need to develop molecule-targeted drugs. Programmed death-ligand 1 (PD-L1) is associated with the prognosis of several cancer types, and blockade of PD-1/PD-L1 signaling increases the amplitude of anti-tumor immunity.

Microstructural Alterations in Asymptomatic and Symptomatic Patients with Spinocerebellar Ataxia Type 3: A Tract-Based Spatial Statistics Study.

Objective: Spinocerebellar ataxia type 3 (SCA3) is the most commonly occurring type of autosomal dominant spinocerebellar ataxia. The present study aims to investigate progressive changes in white matter (WM) fiber in asymptomatic and symptomatic patients with SCA3.

Methods: A total of 62 participants were included in this study.

Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons of the brain, brainstem and spinal cord. To date, mutations in more than 30 genes have been linked to the pathogenesis of ALS. Among them, SOD1, FUS and TARDBP are ranked as the three most common genes associated with ALS.

Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia.

Schizophrenia (SCZ) is a serious psychiatric disease with strong heritability. Its complexity is reflected by extensive genetic heterogeneity and much of the genetic liability remains unaccounted for. We applied a combined strategy involving detection of copy number variants (CNVs), whole-genome mapping, and exome sequencing to identify the genetic basis of autosomal-dominant SCZ in a Chinese family.

A self-interfering clock as a "which path" witness.

In Einstein's general theory of relativity, time depends locally on gravity; in standard quantum theory, time is global-all clocks "tick" uniformly. We demonstrate a new tool for investigating time in the overlap of these two theories: a self-interfering clock, comprising two atomic spin states. We prepare the clock in a spatial superposition of quantum wave packets, which evolve coherently along two paths into a stable interference pattern.

Compact diode-laser-pumped quantum light source based on four-wave mixing in hot rubidium vapor.

Using a nondegenerate four-wave mixing process in hot rubidium vapor, we demonstrate a compact diode-laser-pumped system for the generation of intensity-difference squeezing down to 8 kHz with a maximum squeezing of -7 dB. To the best of our knowledge, this is the first demonstration of kilohertz-level intensity-difference squeezing using a semiconductor laser as the pump source. This scheme is of interest for experiments involving atomic ensembles, quantum communications, and precision measurements.

Temporally multiplexed storage of images in a gradient echo memory.

We study the storage and retrieval of images in a hot atomic vapor using the gradient echo memory protocol. We demonstrate that this technique allows for the storage of multiple spatial modes. We study both spatial and temporal multiplexing by storing a sequence of two different images in the atomic vapor.

Realization of low frequency and controllable bandwidth squeezing based on a four-wave-mixing amplifier in rubidium vapor.

We experimentally demonstrate the creation of two correlated beams generated by a nondegenerate four-wave-mixing amplifier at λ=795 nm in hot rubidium vapor. We achieve intensity difference squeezing at frequencies as low as 1.5 kHz which is so far the lowest frequency to observe squeezing in an atomic system.