OM85 ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting Notch expression and modulating the IFN-γ/IL-4 ratio.

Th1/Th2 balances may play a vital role in the processes of inflammation and fibrosis. The Th1/Th2 paradigm can be evaluated by representing IFN-γ for Th1 and IL-4 for Th2. OM-85 BV encouraged preferential development of the Th1-type immunity characterized by amplified IFN-γ and decreased IL-4 production.

A risk-predictive model for obstructive sleep apnea in patients with chronic obstructive pulmonary disease.

Background: Obstructive sleep apnea syndrome (OSA) is increasingly reported in patients with chronic obstructive pulmonary disease (COPD). Our research aimed to analyze the clinical characteristics of patients with overlap syndrome (OS) and develop a nomogram for predicting OSA in patients with COPD.

Methods: We retroactively collected data on 330 patients with COPD treated at Wuhan Union Hospital (Wuhan, China) from March 2017 to March 2022.

Development and validation of a predictive model for new-onset atrial fibrillation in sepsis based on clinical risk factors.

Objective: New-onset atrial fibrillation (NOAF) is a common complication and one of the primary causes of increased mortality in critically ill adults. Since early assessment of the risk of developing NOAF is difficult, it is critical to establish predictive tools to identify the risk of NOAF.

Methods: We retrospectively enrolled 1,568 septic patients treated at Wuhan Union Hospital (Wuhan, China) as a training cohort.

Stress distribution patterns during the gait cycle in patients with anterior femoral notching following total knee replacement.

Background: Anterior femoral notching (AFN) is a severe complication of total knee replacement (TKR), which in a percentage of patients may lead to fractures after surgery. The purpose of this study was to investigate the stress distribution in patients with AFN and the safety depth of AFN during the gait cycle.

Methods: We performed a finite element (FE) analysis to analyse the mechanics around the femur during the gait cycle in patients with AFN.

[Accuracy of patellar tendon at the attachment as anatomic landmark for rotational alignment of tibial component].

Objective: To investigate the accuracy of the modified Akagi line which referenced the patellar tendon at the attachment and the geometrical center point of the tibial osteotomy surface for tibial rotational alignment.

Methods: Between July 2021 and December 2021, 72 patients who underwent three-dimension (3D) CT for varus osteoarthritis knees were enrolled. Among 72 patients, 18 were male and 54 were female with a mean age of 64.

Approaching 18% efficiency of ternary organic photovoltaics with wide bandgap polymer donor and well compatible Y6 : Y6-1O as acceptor.

A series of ternary organic photovoltaics (OPVs) are fabricated with one wide bandgap polymer D18-Cl as donor, and well compatible Y6 and Y6-1O as acceptor. The open-circuit-voltage ( ) of ternary OPVs is monotonously increased along with the incorporation of Y6-1O, indicating that the alloy state should be formed between Y6 and Y6-1O due to their excellent compatibility. The energy loss can be minimized by incorporating Y6-1O, leading to the improvement of ternary OPVs.

Porous tantalum implant for treatment of early-stage osteonecrosis of the femoral head: a minimum 5-year follow-up study.

Background: To evaluate the survival rate of porous tantalum rod implantation in the treatment of osteonecrosis of the femoral head (ONFH), evaluate its clinical effect and imaging results.

Methods: From January 2008 to December 2013, porous tantalum rod implantation for ONFH was performed in two institutions. Statistical analysis of operation data, including operation time, blood loss and blood transfusion were recorded.

Cognitive behavioral therapy cannot relieve postoperative pain and improve joint function after total knee arthroplasty in patients aged 70 years and older.

Purpose: A randomized controlled trial was conducted to investigate whether cognitive behavioral therapy (CBT) can improve postoperative pain, knee function, and negative emotion in patients aged 70 years and older who underwent total knee arthroplasty (TKA).

Methods: This study used randomized, parallel group, controlled trial to divide the included 90 patients into CBT group and usual care group. The primary outcome measure of the study was the Visual Analogue Scale (VAS) at activity.

Staged vs simultaneous bilateral unicompartmental knee arthroplasty for clinical outcomes: A protocol of systematic review and meta-analysis.

Background: Bilateral unicompartmental knee arthroplasty (UKA) can be divided into one or two stages clinically. Compared with staged bilateral UKA, whether simultaneous bilateral UKA has better clinical efficacy remains to be verified.

Methods: PubMed, EBSCO, and Web of Science were searched by us for meta-analysis.

Early Stage Versus Late Stage Periarticular Injection during Unicompartmental Knee Arthroplasty for Postoperative Pain Relief: A Randomized Controlled Trial.

Controlling postoperative pain after unicompartmental knee arthroplasty (UKA) is essential to improve patient satisfaction and promote early recovery. The purpose of this study was to investigate the difference in clinical efficacy between early and late stage periarticular injection during UKA for postoperative pain relief. Eighty-four patients meeting the inclusion and exclusion criteria were randomly divided into the early stage periarticular injection group and late stage periarticular injection group by using a random number tables method.

Radiotherapy for the prophylaxis of heterotopic ossification after total hip arthroplasty: A systematic review and meta-analysis of randomized controlled trails.

Heterotopic ossification (HO) refers to the formation of lamellar bone in soft tissues and is a significant complication after total hip arthroplasty (THA). Radiotherapy has been proven as an effective prophylaxis especially for those patients with high risk of HO after THA. However the dose, timing, and frequency of radiation have yet to be determined.

Alloy-like ternary polymer solar cells with over 17.2% efficiency.

Ternary strategy has been considered as an efficient method to achieve high performance polymer solar cells (PSCs). A power conversion efficiency (PCE) of 17.22% is achieved in the optimized ternary PSCs with 10 wt% MF1 in acceptors.

Over 15.7% Efficiency of Ternary Organic Solar Cells by Employing Two Compatible Acceptors with Similar LUMO Levels.

Efficient organic solar cells (OSCs) are fabricated using polymer PM6 as donor, and IPTBO-4Cl and MF1 as acceptors. The power conversion efficiency (PCE) of IPTBO-4Cl based and MF1 based binary OSCs individually arrive to 14.94% and 12.

Semitransparent polymer solar cells with 12.37% efficiency and 18.6% average visible transmittance.

A series of opaque and semitransparent polymer solar cells (PSCs) were fabricated with PM6:Y6 as active layers, and 100 nm Al or 1 nm Au/(20, 15, 10 nm) Ag layer as electrode, respectively. The power conversion efficiency (PCE) of opaque PSCs arrives to 15.83% based on the optimized active layer with a thickness of 100 nm, resulting from the well-balanced photon harvesting and charge collection.

Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.

A series of new ferulic acid derivatives were designed, synthesized and evaluated as multi-target inhibitors against Alzheimer's disease. In vitro studies indicated that most compounds showed significant potency to inhibit self-induced β-amyloid (Aβ) aggregation and acetylcholinesterase (AChE), and had good antioxidant activity. Specifically, compound 4g exhibited the potent ability to inhibit cholinesterase (ChE) (IC, 19.

A new dicyanoisophorone-based ratiometric and colorimetric near-infrared fluorescent probe for specifically detecting hypochlorite and its bioimaging on a model of acute inflammation.

To explore how hypochlorous acid (HClO) affects human health, a highly sensitive, selective, and trace detection method for hypochlorite (ClO) is crucial for determining its non-negligible function in both environment and living systems. Herein, a dicyanoisophorone-phenylboronic acid-based novel ratiometric near-infrared fluorescent probe (Probe 1) was designed for the rapid and specific detection of ClO based on the intramolecular charge transfer (ICT) mechanism. Excess addition of HClO to the Probe 1 solution, 186-times ratio (I/I) augment were gained.

One key issue in characterization of organic solar cells with solution processed interfacial layers.

Solution processed interfacial layers are commonly employed in bulk heterojunction organic solar cells (OSCs) for better charge collection. PDIN interfacial layers were prepared by employing a static or dynamic spin coating method from PDIN methanol solution, and defined as the S-PDIN or D-PDIN layer. The OSCs with a S-PDIN layer exhibit 13.