Formation of the self-assembled magnesium oxychloride cement in the alkali-activated geopolymerized municipal solid waste incineration fly ashes and exploration of interactive mechanisms.

The disposal of municipal solid waste incineration fly ashes (MSWI-FA) is complicated by soluble chlorides, which increase the risk of heavy metals (HMs) leaching toxicity and hinder the further use of remediated MSWI-FA. In this study, the self-assembly potentiality of magnesium oxychloride cement (MOC) in geopolymerization was explored and utilized to enhance the solidification/stabilization (S/S) of the MSWI-FA. The MOC-self-assembled geopolymerization kinetics can be suitably described by the JMAK model.

A Deep Learning-Augmented Density Functional Framework for Reaction Modeling with Chemical Accuracy.

Accurate prediction of reaction energetics remains a fundamental challenge in computational chemistry, as conventional density functional theory (DFT) often fails to reconcile high accuracy with computational efficiency. Here, we introduce Deep post-Hartree-Fock (DeePHF), a machine learning framework that integrates neural networks with quantum mechanical descriptors to achieve CCSD-(T)-level precision while retaining the efficiency of DFT to solve the reaction problems. By establishing a direct mapping between the eigenvalues of local density matrices and high-level correlation energies, DeePHF circumvents the traditional accuracy-scalability tradeoff.

Comparison of Ciprofol Versus Propofol for the General Anaesthesia During Gynecological Day Surgery: A Prospective, Randomized, Double-Blind, Non-Inferiority Trial.

Purpose: To compare the safety and efficacy of ciprofol and propofol in general anesthesia for gynecological day surgery.

Patients And Methods: A total of 196 patients undergoing gynecological day surgery under general anesthesia were randomly divided into ciprofol and propofol group. All patients received total intravenous anesthesia.

Efficacy and safety of atezolizumab and bevacizumab with or without TACE as first-line therapy for unresectable HCC: a multicenter cohort study.

Background And Aims: Transarterial chemoembolization (TACE) combined with immunotherapy and targeted therapy provides a promising therapy for unresectable hepatocellular carcinoma (HCC). This study aimed to compare the efficacy and safety of TACE combined with atezolizumab and bevacizumab (TACE-Ate-Bev) or atezolizumab and bevacizumab alone (Ate-Bev) as first-line treatment for unresectable HCC.

Methods: This multicenter cohort study recruited patients with unresectable HCC who received TACE-Ate-Bev or Ate-Bev as first-line treatment between July 1, 2020 and December 31, 2023.

Mechanism of Shenyuan Yiqi Huoxue capsule alleviating coronary microvascular dysfunction: network analysis and experimental evidence.

Background: Shenyuan Yiqi Huoxue Capsule (SYYQ) has clinical evidence to improve coronary microvascular dysfunction (CMD) by tonifying qi and removing blood stasis, but the underlying mechanism remains unclear.

Objective: This study aims to explore the mechanism by which SYYQ alleviates CMD through a combination of network analysis and both and experiments.

Methods: First, network pharmacology was employed to predict the mechanism of SYYQ on CMD.

Characteristics and risk factors for medical malpractice among obstetric and gynecologic physicians in China.

Background: Limited information is available on malpractice claims against obstetricians and gynecologists in China. This study identifies risk factors associated with malpractice and explores the correlation between the hospital characteristics and medical errors in obstetrics and gynecology.

Methods: This observational study analyzed all obstetric and gynecologic malpractice claims submitted to the Chinese Medical Association (CMA) from 2016 to 2023.

Emodin Alleviates Sepsis-Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL-10.

Sepsis is a life-threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation. Neutrophil extracellular traps (NETs) formation bridges these two pathological processes. Through both in vivo and in vitro experiments, it is observed that Emodin, a natural anthraquinone derivative derived from Dahuang, significantly ameliorates the cytokine storm and coagulation abnormalities induced by sepsis, demonstrating remarkable efficacy in inhibiting NETs formation.

Highly sensitive detection of cervical cancer biomarker miR-21 using surface-enhanced Raman scattering (SERS).

Cervical cancer's frequent late-stage diagnosis due to asymptomatic progression necessitates advanced early detection tools. This study pioneers a SERS platform for ultrasensitive detection of miR-21-a key cervical cancer biomarker-combining thiol-modified DNA probes for high-affinity miR-21 capture with AgNP-enhanced SERS substrates that convert hybridization events into amplified Raman signals. The platform achieves sensitivity in serum and demonstrates exceptional stability through DNA-RNA duplex formation, enabling robust reproducibility in complex biofluids.

Rosa roxburghii Tratt fruit extract ameliorate free fatty acid induced steatosis in HepG2 cells through activating PI3K-Akt and PPAR pathways.

There has been a continuous increase in the global incidence of obesity. Rosa roxburghii Tratt (RRT), a plant with medicinal and edible uses, contains active components that can alleviate obesity, indicating an anti-obesity potential. This research sought to investigate the anti-obesity effects of RRT fruit extract (RRTE) and elucidate the underlying mechanisms and components responsible for its action.

Taurine up-regulated 1: A dual regulator in immune cell-mediated pathogenesis of human diseases.

Taurine up-regulated 1 (TUG1) is a long non-coding RNA (lncRNA) that plays a significant role in the pathogenesis of both cancer and non-cancer diseases. Recent studies have revealed its involvement in regulating the development of various diseases by modulating the activity of the body's immune cells. In non-cancer diseases, TUG1 primarily influences disease progression through the competing endogenous RNA (ceRNA) network, promoting the expression of pro-inflammatory cytokines via pathways such as the NF-κB inflammatory signaling pathway.

Identification and Validation of a Prognostic Model Based on Tumour Necrosis Factor-Related mRNAs for Kidney Renal Clear Cell Carcinoma.

Tumour necrosis factor (TNF) plays a critical role in tumour progression, but the specific involvement of mRNA in this process, particularly in kidney renal clear cell carcinoma (KIRC) remains insufficiently understood. Our study aims to develop a TNF-related mRNA (TRmRNA) model to predict prognosis and inform treatment strategies in KIRC. KIRC expression data from The Cancer Genome Atlas (TCGA) and TNF-related genes (TRGs) from the Genecards database were used to construct and validate a TRmRNA prognostic model.

Liposome encapsulation for casein-derived peptides: Release behavior, digestibility, nutrient absorption, and gut microbiota.

Protein-derived bioactive peptides hold great potential for promoting health while face significant challenges during digestion, including structural degradation by gastrointestinal enzymes and limited stability, which hinder their effective utilization. Encapsulation technology offers a promising solution to protect bioactive peptides and ensure their targeted delivery. In this study, casein peptides (CP) were encapsulated into liposomes (CPL) prepared using the thin-film hydration method.

Prevalence and Risk Factors Associated with Venous Thrombosis in Hospitalized Patients in Eastern Liaoning: A Cross-Sectional Study.

Background: Venous thromboembolism (VTE) is a multifactorial disease that is associated with long-term morbidity, dysfunction, and mortality. Although numerous studies reported on the prevalence and risk factors of VTE in hospitalized patients, the results varied due to the complexity of the disease and differences in genetic characteristics, social environment, and disease spectrum. Therefore, this study aimed to investigate the prevalence, clinical features, and risk factors for VTE in hospitalized patients in the eastern Liaoning.

Extreme Drought Events (1585-1590) and Spatiotemporal Patterns of Infectious Diseases Outbreaks in Ming Dynasty China.

Droughts, historically recognized as drivers of societal transformation, have been implicated in the emergence of infectious diseases. While existing research has concentrated on the impact of climate change on infectious diseases outbreaks in modern, industrialized, and urban settings, there is a dearth of epidemiological evidence regarding the historical interplay between drought and disease. Here, we analyze the 1585-1590 extreme drought in Ming Dynasty China to investigate the concurrent development of drought and infectious diseases, as well as the temporal and spatial effects of drought on disease outbreaks.

Development of Multiplex qPCR Method for Accurate Detection of Enzyme-Producing Psychrotrophic Bacteria.

Microbial detection in milk is crucial for food safety and quality, as beneficial and harmful microorganisms can affect consumer health and dairy product integrity. Identifying and quantifying these microorganisms helps prevent contamination and spoilage. The study employs advanced molecular techniques to detect and quantify the genomic DNA for the target hydrolytic enzyme coding genes and based on the multi-align sequence conserved region, specific primer pair, and hydrolysis probes designed using the singleplex qPCR and multiplex qPCR.

sciLaMA: A Single-Cell Representation Learning Framework to Leverage Prior Knowledge from Large Language Models.

Single-cell RNA sequencing (scRNA-seq) enables high-resolution exploration of cellular diversity and gene regulation, yet analyzing such data remains challenging due to technical and methodological limitations. Existing task-specific deep generative models like Variational Auto-Encoder (VAE) and its variants struggle to incorporate external biological knowledge, while transformer-based foundational large Language Models (LLMs or large LaMs) face limitations in computational cost and applicability to tabular gene expression data. Here, we introduce sciLaMA (single-cell interpretable Language Model Adapter), a novel representation learning framework that bridges these gaps by integrating static gene embeddings from multimodal LLMs with scRNA-seq tabular data through a paired-VAE architecture.

Shared hub genes in membranous nephropathy and kidney renal clear cell carcinoma: investigating molecular overlap and tumor progression.

Background: Membranous nephropathy (MN) and kidney renal clear cell carcinoma (KIRC) are distinct kidney diseases with potential shared molecular mechanisms. Identifying common biomarkers may improve our understanding of disease pathogenesis and provide novel diagnostic and therapeutic targets.

Methods: The study primarily employed bioinformatics tools to analyze publicly available datasets to identify differentially expressed genes (DEGs) and hub genes in KIRC and MN.

Efficacy and Safety of Xinmailong Injection for Chronic Heart Failure: A Systematic Review and Meta-Analysis for Randomized Clinical Trials.

Xinmailong injection (XMLI) is a common Traditional Chinese Medicine for treating chronic heart failure (CHF) in China. However, strong evidence-based medical evidence for XMLI is lacking. To evaluate the efficacy and safety of XMLI in patients with CHF.

Assessing the impacts of climate anomalies on plague risk in China during 1754-1949.

Plague, a disease influenced by climatic and social factors, has historically caused devastating disasters in China. However, limited data availability has hindered our understanding of the relationship between climate, social conditions, and plague. Here we address a critical data gap by collecting and digitizing county-level plague grade data from China during 1754-1949 together with socio-climatic factors.

Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma.

CD19-targeted chimeric antigen receptor T cells (CAR-T19) have shown remarkable success in B cell malignancies, but most patients relapse within 1-2 years. Here, we identified interleukin-1 (IL-1) receptor antagonist (IL-1ra) as a mediator of M2-like macrophage-derived inhibition of CAR-T19 in mantle cell lymphoma (MCL), as well as a potential target to enhance CAR-T19 efficacy. In preclinical models that recapitulated interactions between tumor, macrophages, and T cells, we demonstrated that M2-derived IL-1ra impairs IL-1 signaling and functions of CAR-T19.

Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation.

Background: Evidence for the benefits of resveratrol (Res) in the treatment of asthma is progressively accumulating. However, the full spectrum of its molecular targets and the precise mechanisms remain incompletely characterized.

Method: Targets of Res were obtained from Swiss Target Prediction, TCMCP, and DrugBank.

DiSC: a statistical tool for fast differential expression analysis of individual-level single-cell RNA-seq data.

Motivation: Single-cell RNA sequencing (scRNA-seq) has become an important method for characterizing cellular heterogeneity, revealing more biological insights than the bulk RNA-seq. The surge in scRNA-seq data across multiple individuals calls for efficient and statistically powerful methods for differential expression (DE) analysis that addresses individual-level biological variability.

Results: We introduced DiSC, a method for conducting individual-level DE analysis by extracting multiple distributional characteristics, jointly testing their association with a variable of interest, and using a flexible permutation testing framework to control the false discovery rate (FDR).

Fecal microbiota transplantation alleviates cirrhotic portal hypertension in rats via butyrate-mediated HDAC3 inhibition and PI3K/Akt/eNOS signaling regulation.

Background: Portal hypertension (PHT) is a severe complication of liver cirrhosis, with limited therapeutic options. Despite emerging evidence linking gut microbiota dysbiosis to PHT progression, the mechanisms by which microbial metabolites modulate liver sinusoidal endothelial cells (LSECs) dysfunction and the therapeutic efficacy of fecal microbiota transplantation (FMT) remain poorly understood. This study investigated the potential of FMT to alleviate PHT in cirrhotic rats, exploring the underlying mechanisms involving butyrate-mediated HDAC3 inhibition and PI3K/Akt/eNOS signaling regulation in LSECs.

Utilization of Native CRISPR-Cas9 System for Expression of Glucagon-like Peptide-1 in .

Type 2 diabetes is one of the main causes of cardiovascular diseases, kidney diseases, and visual impairments, posing a global healthcare challenge. The current treatment of this disease, involving glucagon-like peptide-1 (GLP-1), is faced with problems such as frequent injections and plasmid instability. In this study, we used the native clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9 (CRISPR-Cas9) system of to develop a novel, genetically stable, and orally administrable strain expressing human GLP-1.