Polychlorinated biphenyls-153 induces fat accumulation and lifespan shortening through CYP450 family genes in Caenorhabditis elegans.

A class of persistent organic pollutants, polychlorinated biphenyls (PCBs), are ubiquitous in the environment and human tissues which are continuously and long-term threatened. We aim to investigate the toxic effects and the underlying mechanisms of PCB153 using Caenorhabditis elegans as a model organism. Our findings demonstrated that exposure to an optimized concentration of 2 µmol/L PCB153 had adverse effects on C.

EAT-Lancet diet and risk of metabolic dysfunction-associated steatotic liver disease and other liver chronic diseases: a large prospective cohort study in the UK Biobank.

Background And Aim: As a newly recommended healthy dietary blueprint, the EAT-Lancet diet emphasizes both environmental sustainability and human health. However, its impact on chronic liver diseases remains unclear. This study examined the influence of the EAT-Lancet diet on the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) and other chronic liver diseases.

Air pollution and maternal vitamin D Status: Critical time window identification and ultraviolet radiation-mediated pathways.

Background: Maternal vitamin D deficiency (VDD) is a global health concern, with air pollution emerging as a potential risk factor. However, the underlying mechanisms, particularly the mediating role of Ultraviolet Radiation (UVR), remain poorly understood. This study investigated the impact of air pollution exposure, including PM chemical components, on 25-hydroxyvitamin D [25(OH)D] status in pregnant women, focusing on the mediating role of UVR.

Association of the triglyceride-glucose index with risk of depression and anxiety: A prospective cohort study.

Background: The relationship between the triglyceride glucose (TyG) index and depression/anxiety remains unclear. This study prospectively examines whether elevated TyG index increases depression and anxiety risk.

Methods: Our analysis included 383,621 individuals from the UK Biobank who were free of depressive and anxiety disorders at enrollment.

Association between coffee and caffeine consumption and chronic kidney disease.

Chronic kidney disease (CKD) is a significant global health issue associated with cardiovascular complications. While coffee, tea, and caffeine consumption have been linked to various health benefits, their relationship with CKD remains unclear. We conducted a cross-sectional analysis of NHANES 1999-2018 data, including 49,827 participants, assessing dietary intake through two 24-hour recalls and determining CKD status via the CKD-EPI equation.

Association of ambient fine particulate matter and its chemical constituents with preterm birth: a population-based cohort study with sibling comparison design.

Effects of ambient fine particulate matter (PM) chemical constituents on preterm birth (PTB) are inconclusive. We performed a sibling-matched cohort study to explore the association between PM constituents and the risk of PTB. Changes in PM and the constituents (ΔPM ΔOC, ΔBC, ΔSO, ΔNH, ΔNO) were calculated as the value at a follow-up pregnancy minus exposures in prior pregnancy.

Associations of Accelerated Biological Aging With Dementia and the Mediation Role of Brain Structure: Findings From a Longitudinal Study.

Background And Objectives: The association between biological aging and dementia, as well as the underlying mechanism, remains limited. The aim of this study was to investigate the relationships of biological age (BA) with incident dementia and examine the underlying neurobiological mechanisms.

Methods: This study used data from the UK Biobank, a prospective longitudinal study.

Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.

Observational studies have suggested that shorter telomere length (TL) may be a risk factor for psychiatric disorders. However, whether this association underlie causal effects remains unknown. This study aims to investigate the potential association between TL and psychiatric disorders by conducting a bidirectional Mendelian randomization (MR) study.

The mediating mechanism of Oct4 in the process of cleft palate induced by 2, 3, 7, 8-tetrachlorodibenz-p-dioxin (TCDD) and all-trans retinoic acid.

2, 3, 7, 8-tetrachlorodiphenyl-p-dioxin (TCDD) and all-trans retinoic acid (atRA) have been shown to be inducers of cleft palate (CP). Relevant studies have shown that Oct transcription factor 4 (Oct4) can regulate the expression of the aromatic hydrocarbon receptor (AhR), a target gene of TCDD, as well as influence the retinoic acid signaling pathway. However, the mechanism of Oct4 regulating the interaction between TCDD and atRA in CP pathogenesis remains unclear.

Meg3-NONO-RAR axis mediates RA pathway activation in TCDD-induced cleft palate.

Dioxins, a group of environmental pollutants, can cause developmental toxicity through interaction with the aromatic hydrocarbon receptor (AHR). Retinoic acid (RA) functions via binding to retinoic acid receptor (RAR)/retinoid X receptor (RXR). Both AHR and RA pathways can be activated by dioxins.

Human health risks of heavy metals in water and vegetables: a deterministic and probabilistic study in Gilgit-Baltistan, Pakistan.

There is a growing global concern about the presence of heavy metals in the environment due to their detrimental effects on human health. These metals are eminent poisons with carcinogenic features that can harm organs such as brain, kidney, lungs, etc. This study investigated the human health risks associated with toxic metals such as lead (Pb), nickel (Ni), cadmium (Cd), chromium (Cr), and copper (Cu) in drinking water and vegetable sources from Northern Areas, Gilgit-Baltistan, Pakistan.

Ambient ozone exposure and pregnancy complications and adverse birth outcomes: A systematic review and meta-analysis.

Background: Ambient ozone pollution is becoming a global health threat under global warming. Evidence on the association between ambient ozone and pregnancy complications and adverse birth outcomes has grown enormously. To provide a comprehensive assessment of the evidence, we performed a systematic review and meta-analysis to outline current epidemiological evidence.

Evaluating the Carcinogenic and Non-Carcinogenic Health Risks of Heavy Metals Contamination in Drinking Water, Vegetables, and Soil from Gilgit-Baltistan, Pakistan.

Environmental pollutants significantly impact health and quality of life. High levels of harmful metals in drinking water, vegetables, and soil can accumulate in the body, leading to serious health issues. In Gilgit-Baltistan, Pakistan, the prevalence of cancer is notably high, and heavy metals are considered among the possible risk factors.

The mechanism of all-trans retinoic acid-induced cleft palate may be related to the novel ENSMUST00000159153-miR-137-5p-Wnt7a and ENSMUST000000236086-miR-34b-3p-EphA10/TRPM2 ceRNA crosstalk.

Cleft palate is the most prevalent congenital condition. Cleft palate is brought on by an exogenous chemical called all-trans retinoic acid (atRA). In order to indirectly control gene expression, long chain non-coding RNAs (lncRNAs) act as competitive endogenous RNA (ceRNA) sponges.

AKT/mTOR-mediated autophagic signaling is associated with TCDD-induced cleft palate.

In utero exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can contribute to high rates of cleft palate (CP) formation, but the mechanistic basis for these effects remains uncertain. Here, multi-omics-based metabolomic and transcriptomic analyses were employed to characterize the etiological basis for TCDD-induced CP on gestational day 14.5 (GD14.

Association between organophosphate esters exposure and all-cause and cause-specific mortality: a national population-based cohort study.

Exposure to organophosphate esters (OPEs) is associated with several chronic diseases, but the relationship with mortality risk is unclear. Therefore, we used the National Health and Nutrition Examination Survey 2011-2018 data to evaluate these relationships. 6,869 participants aged 18 years or older were included.

Recognition and detection technology for microplastic, its source and health effects.

Microplastic (MP) is ubiquitous in the environment which appeared as an immense intimidation to human and animal health. The plastic fragments significantly polluted the ocean, fresh water, food chain, and other food items. Inadequate maintenance, less knowledge of adverse influence along with inappropriate usage in addition throwing away of plastics items revolves present planet in to plastics planet.

Upregulated LncRNA-Meg3 modulates the proliferation and survival of MEPM cells via interacting with Smad signaling in TCDD-induced cleft palate.

Exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero can result in high rates of cleft palate (CP) formation, yet the underlying mechanisms remain to be characterized. In vivo, the lncRNA Meg3 was upregulated following TCDD treatment in CP-associated murine embryonic palatal tissue, with concomitant changes in proliferative and apoptotic activity in these murine embryonic palatal mesenchymal (MEPM) cells. Meg3 can modulate the TGF-β/Smad to control the proliferation, survival, and differentiation of cells.

Cadmium-induced reproductive toxicity combined with a correlation to the oogenesis process and competing endogenous RNA networks based on a Caenorhabditis elegans model.

Accumulation of the heavy metal Cadmium (Cd) in the ovaries and placenta can affect the structure and function of these organs and induce female reproductive toxicity. This toxicity may be due to Cd's similarity to estrogen and its ability to disrupt endocrine systems. However, the exact molecular mechanism by which Cd causes reproductive toxicity at the transcriptome level remains poorly understood.

Dynamic changes in ambient PM and body mass index among old adults: a nationwide cohort study.

Outdoor air pollution has been considered as a severe environmental health issue that almost affecting everyone in the world, and intensive actions were launched. However, little is known about the association between dynamic changes in ambient fine particulate matter (PM) exposure and body mass index (BMI) among old adults. To investigate the dynamic changes in ambient PM and body mass index among the elderly, we included a total of 7204 participants from 28 provinces of China during 2011-2015 in the China Health and Retirement Longitudinal Study (CHARLS).

Associations between the proliferation of palatal mesenchymal cells, Tgfβ2 promoter methylation, Meg3 expression, and Smad signaling in atRA-induced cleft palate.

All-trans retinoic acid (atRA) is a teratogen that can induce cleft palate formation. During palatal development, murine embryonic palate mesenchymal (MEPM) cell proliferation is required for the appropriate development of the palatal frame, with Meg3 serving as a key regulator of the proliferative activity of these cells and the associated epithelial-mesenchymal transition process. DNA methylation and signaling via the TGFβ/Smad pathway are key in regulating embryonic development.

Association of greenspace with hypertension in adult: a systematic review and meta-analysis of epidemiological studies.

Background: Several studies have investigated the relationship of greenspace with blood pressure (BP) and hypertension, but the results were inconsistent. We aimed to assess the relationship of greenspace with BP/hypertension.

Methods: We searched PubMed, Embase and Web of Science on greenspace and BP/hypertension published before 5 April 2023.

Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis.

Background: Birth weight (BW) is an indicator of fetal growth and development. Previous studies showed inconsistent results on the association of ambient particulate matter (PM) exposure with BW, and the role of maternal thyroid function has not been clarified.

Methods: We recruited 1711 gravidas between 2017 and 2019 in Henan, China.