Proteomics and metabolomics studies in pigmented villonodular synovitis uncover the regulation of monocyte differentiation by the ADGRE5-NF-κB pathway.

Background: Pigmented villonodular synovitis (PVNS), or tenosynovial giant cell tumor (TGCT), is a locally aggressive soft tissue tumor primarily affecting the synovium of joints, particularly the knee. In PVNS, the synovial tissue thickens and becomes aggressive, leading to joint destruction, a process reminiscent of the tissue remodeling seen in autoimmune diseases. Despite being considered benign, PVNS often leads to severe joint damage and has a high recurrence rate following treatment.

Pars plana vitrectomy followed by subretinal or intravitreal injection with Conbercept and tissue plasminogen activator for clearance of submacular hemorrhage secondary to idiopathic polypoidal choroidal vasculopathy.

Purpose: The optimal treatment approach for submacular hemorrhage (SMH) secondary to idiopathic polypoid choroidal vasculopathy (IPCV) remains uncertain. This study aimed to explore the prognosis and complications of pars plana vitrectomy (PPV) followed by subretinal or intravitreal injection with Conbercept (0.05 ml, 10 mg/ml) and tissue plasminogen activator (t-PA) (0.

Comparison of extracorporeal shockwave therapy, ultrasound therapy, and corticosteroid injections for treatment of lateral epicondylitis: an umbrella review of meta-analyses.

Background: The purpose of this study was to assess the methodological quality of meta-analyses (MAs) and resolve evidence inconsistencies by quantifying overlap in primary studies, thereby providing enhanced evidence on the efficacy of extracorporeal shockwave therapy (ESWT) versus placebo, ultrasound therapy, and corticosteroid injections for lateral epicondylitis.

Methods: We conducted searches in four databases: PubMed, Embase, Cochrane Library, and Web of Science, until August 2024. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Suture Bridge Technique for Arthroscopic Repair of Posterior Cruciate Ligament Tibial Avulsion.

Arthroscopy has gradually become the routine method to treat posterior cruciate ligament tibial insertion avulsion. However, arthroscopic surgery possesses the advantages of being minimally invasive, having a good appearance, and having no need for revision surgery for internal fixation. Compared with open surgery, it is limited by disadvantages such as unstable fixation, unsatisfactory reduction, and fracture fragment displacement.

Is Bone Mineral Density at the Tendon-Bone Interface After ACL Reconstruction Associated With Graft Maturation? A Quantitative Computed Tomography Analysis.

Background: The revision rate due to postoperative instability after anterior cruciate ligament reconstruction (ACLR) remains at 4% to 25%. The physiological mechanisms of tendon-bone healing involve intricate processes, particularly neovascularization and osseointegration at the bone tunnel interface. Currently, no standardized noninvasive method exists to comprehensively evaluate tendon-bone healing progression.

Salt Stress Responses of Different Rice Varieties at Panicle Initiation: Agronomic Traits, Photosynthesis, and Antioxidants.

The utilization of saline-alkali land for rice cultivation is critical for global food security. However, most existing studies on rice salt tolerance focus on the seedling stage, with limited insights into tolerance mechanisms during reproductive growth, particularly at the panicle initiation stage (PI). Leveraging precision salinity-control facilities, this study imposed four salt stress gradients (0, 3, 5, and 7‱) to dissect the differential response mechanisms of six rice varieties (YXYZ: Yuxiangyouzhan, JLY3261: Jingliangyou3261, SLY91: Shuangliangyou91, SLY138: Shuangliangyou138, HLYYHSM: Hualiangyouyuehesimiao, and SLY11:Shuangliangyou111) during PI.

Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis.

Background: Intermittent claudication (IC) is a common manifestation of peripheral arterial disease. This study evaluates the efficacy of extracorporeal shock wave therapy (ESWT), a non-invasive treatment, for patients with IC.

Methods: A systematic review and meta-analysis of four major databases (PubMed, Embase, Cochrane Library, Web of Science) was conducted through March 2025.

Exploratory study on the association of fish consumption with serum cotinine levels in the general adult population.

Background: This cross-sectional study examined the association between fish consumption and serum cotinine levels, a biomarker of tobacco exposure, among adults in the United States.

Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. A total of 32,766 participants were included after applying eligibility criteria.

Dexmedetomidine Stimulates Cellular Senescence of Lung Cancer Cells Via NOX5.

Dexmedetomidine is a highly selective α- 2 adrenergic receptor agonist which has been considered as a promising anticancer agent. However, the underlying molecular mechanisms whereby Dexmedetomidine exerts its anticancer and chemopreventive actions need to be elucidated. In this study, we found that Dexmedetomidine reduced cell viability of the lung cancer cell line A549 cells in a dose-dependent manner.

Beverage consumption on bone and joint disorders: an umbrella review.

Background: Bone and joint disorders significantly contribute to disability worldwide. While meta-analyses have explored the relationship of these diseases and beverage consumption, the results remain inconsistent. In this umbrella review, we synthesised existing evidence to clarify these associations.

Can peroneus longus tendon autograft become an alternative to hamstring tendon autograft for anterior cruciate ligament reconstruction: a systematic review and meta-analysis of comparative studies.

Purpose: To perform a meta-analysis to compare and critically evaluate the short and medium-term clinical outcomes of peroneus longus tendon autograft and hamstring tendon autograft in anterior cruciate ligament (ACL) reconstruction. The study further evaluates the viability of the PLT autograft as a non-inferior alternative to the conventional HT autograft.

Method: We independently searched the following electronic databases: PubMed, Cochrane Library, Embase, and Web of Science for all relevant articles from inception to March 2025, in only the English language.

The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study.

While the central mechanisms of fibromyalgia have gained attention, the causal effects between brain networks and fibromyalgia remain unclear. Two-sample Mendelian randomization and Linkage Disequilibrium Score Regression were performed to investigate the relationship between 191 rsfMRI traits and 8 fibromyalgia-related traits. A total of 4 rsfMRI traits were genetically correlated with trouble falling asleep, 11 with back pain for 3+ months, 16 with pain all over the body, 14 with insomnia, 5 with fibromyalgia, 4 with fibromyalgia, and 3 with malaise and fatigue.

Emerging Applications of Photodynamic and Sonodynamic Therapies in Orthopedic Disorders: Mechanisms, Challenges, and Future Directions.

As non-invasive targeted therapeutic modalities, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have demonstrated significant clinical potential in orthopedic disorders management. PDT generates reactive oxygen species (ROS) through photosensitizer activation under specific light wavelengths, selectively inducing apoptosis in pathological cells. SDT employs sonosensitizers activated by low-intensity ultrasound to produce ROS while offering enhanced depth of tissue penetration.

Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.

Cerebral amyloid angiopathy (CAA) and insomnia are age-related neurological disorders increasingly recognized as being closely associated. However, research on the shared genes and their biological mechanisms remains limited. This study aims to identify common genes between CAA and insomnia and explore their potential molecular mechanisms, offering new insights for diagnosis and treatment.

Functional nucleic acid-powered hybrid nanocarriers for synchronized targeted delivery of dual-solubility therapeutics.

Combination chemotherapy presents a promising approach to overcome multidrug resistance in cancer treatment. However, conventional delivery systems struggle to achieve synchronized co-delivery of hydrophilic and hydrophobic therapeutics with tumor-specific targeting and controlled release. Here, we developed a multifunctional nanocarrier integrating poly (lactic-co-glycolic acid) nanoparticles with polydopamine and programmable nucleic acids.

Osteoimmunology and aging: Mechanisms, implications, and therapeutic perspectives.

Osteoimmunology is an interdisciplinary study of the interaction between the immune system and the skeletal system, aiming to reveal the immune regulation mechanisms that affect bone health and disease. Aging is a macro concept, which is not limited to the senescence of cells, but also includes the aging of the body as a whole. Studies have shown that aging can affect osteoimmune function through various mechanisms such as affecting the bone marrow microenvironment, causing immune cell dysfunction, triggering inflammatory responses, and destroying bone homeostasis, leading to the occurrence of bone diseases.

Analgesic effects of dexmedetomidine combined with shoulder nerve blocks before arthroscopy: a meta-analysis of randomized-controlled trials.

Purpose: Dexmedetomidine is a widely employed adjunct in nerve block anesthesia for shoulder arthroscopy. This study aimed to assess the analgesic efficacy of dexmedetomidine as a nerve block adjuvant in patients undergoing shoulder arthroscopy.

Methods: A thorough search of PubMed/MEDLINE, Embase, Web of Science and the Cochrane Library databases was conducted to identify randomized-controlled trials comparing the effects of dexmedetomidine-enhanced shoulder arthroscopy nerve blocks against those without dexmedetomidine.

Application of hyperbaric oxygen therapy in femoral head necrosis: a systematic review and meta-analysis.

Purpose: To evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of osteonecrosis of the femoral head (ONFH).

Methods: Search for term systems related to ONFH and HBOT in PubMed, Cochrane Library, Embase and Web of Science databases. The risk ratio (RR) was used as the effective index for dichotomous variables while mean difference (MD) and 95% confidence interval (CI) were used as the effective index for continuous variables, with a two-sided P < 0.

Treatments for rotator cuff calcific tendinitis: a systematic review and network meta-analysis of randomized-controlled trials.

Purpose: Various conservative and surgical treatments was clinically applied in rotator cuff calcific tendinitis (RCCT), the evaluation of distinction among all available intervention is still lacking. This study aims to systematically compare the efficacy and safety of these interventions and provide guidance for RCCT treatment.

Methods: The study utilized four electronic databases for literature retrieval and is registered in PROSPERO.

Leukocyte-Rich Platelet-Rich Plasma's Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials.

: Arthroscopic rotator cuff repair faces high retear risks in multi-tendon injuries due to insufficient biological healing; leukocyte-rich PRP may enhance tendon-bone integration through inflammatory modulation and growth factor release. : Four databases including PubMed, Embase, Cochrane Library, and Web of Science were searched until March 2025. Literature screening, quality evaluation, and data extraction were performed according to inclusion and exclusion criteria.

Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies.

The causal impact of blood metabolites on OA has yet to be definitively established, further studies are needed to explore the specific roles of metabolites in OA. This is a genetic correlation and two-sample bidirectional mendelian randomization study. GWAS summary data of metabolites and OA were extracted from large-scale GWAS study based on Europeans and Asians.

Biomarkers for sarcopenia, muscle mass, muscle strength, and physical performance: an umbrella review.

Background: Biomarkers in sarcopenia have garnered increasing interest. This study aims to systematically identify biomarkers with potential diagnostic significance for sarcopenia, as well as those exhibiting correlations with sarcopenia, particularly biomarkers reporting quantitative pooled data.

Methods: This umbrella review adhered to the PRISMA 2020 guidelines.

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects.

Resveratrol (RES), a naturally occurring polyphenolic compound, has garnered significant attention due to its diverse biological activities, which include anti-inflammatory, antioxidant, and antiaging properties. This review synthesizes current evidence concerning the molecular mechanisms, therapeutic efficacy, and safety profile of RES across a variety of pathologies, with an emphasis on the latest research conducted in recent years. Mechanistically, RES is known to modulate critical signaling pathways such as the activation of sirtuin 1.

Causal Relationship Between Blood Metabolites and Osteoporosis: A Two-Sample Mendelian Randomization and Genetic Correlation Analysis.

Osteoporosis (OP) is a systemic bone disease often undiagnosed until fractures occur. Metabolites may influence OP, offering potential biomarkers or therapeutic targets. This study investigates the causal relationship between circulating metabolites and OP-related phenotypes using Mendelian Randomization (MR).

Suture tape augmentation in the management of anterior cruciate ligament ruptures: a systematic review and meta-analysis.

Background: The employment of suture tape augmentation (SA) in surgical interventions for anterior cruciate ligament (ACL) ruptures is a subject of ongoing debate. This meta-analysis synthesizes prior research to assess the effectiveness of additional SA in treating ACL tears.

Methods: A total of four databases including PubMed, Embase, Cochrane Library, and Web of Science were searched up to September 2024.