Sub-nanometer FeOOH clusters drive mercury immobilization and methylation inhibition in paddy soil-water systems via iron-modified biochar.

Mercury (Hg) contamination in paddy systems poses severe environmental and public health threats due to the microbial transformation of inorganic Hg into highly toxic methylmercury (MeHg). Although biochar (BC) has been widely applied for heavy metal remediation, its limited capacity to immobilize Hg constrains its practical effectiveness. Here, we present a comprehensive study combining batch experiments and density functional theory (DFT) calculations to elucidate the molecular mechanisms by which iron-modified biochar (Fe-BC) enhances Hg stabilization and inhibits MeHg formation in paddy systems.

A Polar Zinc-Based Water-Resistant White-Light Emission Organic Inorganic Hybrid Metal Halide.

Developing lead-free hybrid metal halides with stable and efficient white-light emission remains a critical challenge for next-generation optoelectronics. Here, we report a polar zinc-based organic-inorganic hybrid halide, [EMPA]ZnBr (EMPA = 5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-amine), which exhibits broadband white-light emission with a high color rendering index of 90 and high photoluminescence quantum yield of 43.9%.

Artificial neurons made of active matter memristors.

In this study we propose a new class of artificial neurons and memristors made of active chiral particles. We formulate a single-particle model to simulate active chiral particle behavior in a two-terminal device, with resistance depending on the particle position. We create a dynamical phase map connecting particle trajectories and memristor electrical properties to applied voltage and particle's self-propulsion parameters.

RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.

Resistance to tyrosine kinase inhibitors (TKIs) dampens their clinical efficacy in hepatocellular carcinoma (HCC). Stress granules formed by phase separation are essential to stress response and can be involved in therapy resistance, but their mechanisms in HCC are unclear. Here our screen shows that the atypical serine/threonine kinase RIOK1 is highly expressed in HCC, linked to poor prognosis, and transcriptionally activated by NRF2 under various stress conditions.

Water-Resistant Zero-Dimensional Hybrid Copper Halide for High-Efficiency X-ray Scintillation and Sensitive Fluorescent Probing.

Low-dimensional hybrid metal halides, known for their highly tunable structures and exceptional photophysical properties, have attracted considerable interest for luminescent, optoelectronic, and sensing applications. In this study, we report on the synthesis and characterization of [ACPP]CuBr (ACPP = protonated 1-amino-4-cyclopentylpiperazine), a lead-free zero-dimensional organic-inorganic copper(I) halide with outstanding scintillation performance. The material achieves a high photoluminescence quantum yield (92.

Analysis of Self-Disclosure and Empathic Interaction Willingness Among Couples with Malignant Gynaecological Tumours.

Objective: This cross-sectional study aimed to analyse the interaction willingness regarding empathy and self-disclosure among patients with malignant gynaecological tumours and their spouses and elucidate the underlying mechanisms.

Methods: A total of 201 couples, each including one partner diagnosed with a malignant gynaecological tumour, were selected using a convenience sampling method between March 2023 and January 2024. Participants' general information, empathy capabilities, self-disclosure and support coping were assessed by a general information questionnaire, the Interpersonal Reactivity Index-C, the Distress Disclosure Index and the Couple Support Coping Scale, respectively.

Dual-emission fluorescent probe with sequential two-step ESIPT activation mechanism for selective hydrazine detection and multifunctional applications.

Hydrazine is a commonly used chemical in various industries, including pharmaceuticals, agriculture, and aerospace. However, its high toxicity may cause serious harm to the natural environments and human health. The development of new methods for sensitive and selective detection of hydrazine is of great significance.

Single-Cell Sequencing-Guided Annotation of Rare Tumor Cells for Deep Learning-Based Cytopathologic Diagnosis of Early Lung Cancer.

Deep learning (DL) models for medical image analysis are majorly bottlenecked by the lack of well-annotated datasets. Bronchoalveolar lavage (BAL) is a minimally invasive procedure to diagnose lung cancer, but BAL cytology suffers from low sensitivity. The success of DL in BAL cytology is rare due to the rarity of exfoliated tumor cells (ETCs) and their subtle morphological differences from normal cells.

The Correlation Between Medication Self-Management with Rational Medication Use Self-Efficacy and Medication Literacy in Patients with Stroke.

Objective: To investigate medication self-management in patients with stroke and its relationship with general demographics, self-efficacy and medication literacy.

Methods: This was a cross-sectional study. Patients with stroke who received treatment in Jiangnan University Affiliated Hospital between July 2023 and January 2024 were selected as the study participants.

Decreased CCL5 expression in endometrial stromal cells induces deficient CCR5 CD4 T cells in endometriosis.

Endometriosis (EMS) is a benign gynecological disease characterized by the growth of endometrial tissue outside the uterine cavity. Evidence shows that the survival of patients with ectopic endometrial implants is associated with a dysregulated immune microenvironment. CD4 T cells can regulate EMS through diverse cytokines, the inflammatory response, and angiogenesis.

Sclerosing angiomatoid nodular transformation of the spleen: clinical, computed tomography, and magnetic resonance imaging characteristics.

Background: Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a benign, vasculogenic lesion with unclear etiology. Despite increased recognition of its imaging features, the rates of imaging misinterpretation and unnecessary surgery for SANT remain high, and a possible association with benign and malignant tumors have been suggested. This study aimed to systematically analyze the clinical and imaging characteristics of SANT to improve clinician and radiologist knowledge, reduce overtreatment, and increase the awareness of potential concomitant diseases in other organs.

Hydration Mechanism of Solid Waste Gelling Materials Containing Semi-Dry Desulfurization Ash.

This study investigated the feasibility of using semi-dry desulfurization ash (DA) in combination with blast furnace slag (BFS) to prepare gelling materials, aiming to improve the resource utilization of DA. The effects of DA dosage and mechanical grinding on the compressive strength and hydration mechanism of BFS-DA gelling materials were investigated. The results showed that the optimum BFS-DA ratio was 60:40, and the compressive strengths were 14.

SCM-198 Inhibits EMS Development by Reversing Decreased Proportions of IFN-γT Cells and CCR5T Cells.

Endometriosis is a common gynecological disease that causes severe pain and infertility. However, the available treatments for EMS are limited. SCM-198, a synthetic form of leonurine, possesses various abilities, including anti-inflammatory, immunomodulatory, antioxidant, anti-fibrotic, and anti-proliferative effects.

Crystalline phase regulates transformation and methylation of mercury sulfide nanoparticles in paddy systems.

Mercury sulfide nanoparticles (HgS) represent an important source of bioavailable mercury (Hg) for microbial methylation in paddy systems, depending on their size and crystalline phases. However, little is known about the phase compositions of HgS in Hg-contaminated paddy fields with dynamically changed redox conditions, their transformation, and methylation potential. Applying transmission electron microscopy (TEM) and synchrotron radiation X-ray absorption spectroscopy (SR-XAS), we found β-HgS as the predominant Hg species in newly contaminated areas, whereas α-HgS dominated in paddies near mining areas.

A Effector Targets Splicing Factor to Reprogram Alternative Splicing and Regulate Plant Immunity.

Alternative splicing is a critical post-transcriptional regulatory mechanism in eukaryotes. While infection with GMI1000 significantly alters plant alternative splicing patterns, the underlying molecular mechanisms remain unclear. Herein, the effect of the GMI1000 Type III secretion system effectors on alternative splicing in the tomato cultivar Heinz 1706 was investigated.

Screening and Characteristics of Cadmium-Tolerant Microorganisms in Soil Remediation.

Cadmium (Cd) pollution of soil is a severe environmental problem. Bioremediation of Cd-contaminated soil is an environmentally friendly and low-cost remediation method. In this work, three Cd-tolerant fungi strains, named L1, L2, and L3, were screened and domesticated.

Performance Assessment of All-Solid-Waste High-Strength Concrete Prepared from Waste Rock Aggregates.

In order to solve the problems of the large-scale resource utilization of iron ore waste rock, waste rock is used to prepare green building materials, but it needs to be further promoted for use in high-strength concrete. In this study, high-strength concrete was prepared using iron ore waste rock as coarse and fine aggregates combined with solid waste-based cementitious materials. The mechanical and durability properties of washed and unwashed concrete with two types of aggregates were compared, including compressive strength, freeze resistance, chloride ion resistance, carbonation resistance, pore distribution, microstructural characteristics, and environmental and economic benefits.

Auxin signaling related to H-ATPase synthesis and antioxidant enzyme activities regulates fluoranthene uptake by ryegrass roots.

Previous research has shown that fluoranthene (Flu) exhibits dual uptake behavior in ryegrass. At low concentrations (1-10 mg/L), Flu uptake is higher, whereas at higher concentrations (20-40 mg/L), uptake appears to decrease. Furthermore, indole-3-acetic acid (IAA) content and antioxidant enzyme activity play distinct roles in this process.

CT and MRI characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of 11 patients with pathological correlation.

Objective: This study aimed to outline the computed tomography (CT) and magnetic resonance imaging (MRI) characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) in the spleen and to link these imaging features with histopathological findings.

Materials And Methods: A retrospective analysis was conducted on 11 patients (3 males, 8 females; mean age, 63.3 ± 9.

Effects of drought stress on the secondary metabolism of Scutellaria baicalensis Georgi and the function of SbWRKY34 in drought resistance.

The pharmacological properties of the dried root of Scutellaria baicalensis Georgi, a Chinese medicinal herb, include antioxidant, antibacterial, and antiviral effects. In S. baicalensis quality assessment, concentrations of baicalin, wogonoside, baicalein, and wogonin in the root are crucial.

Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity.

Four novel macrocyclic trichothecenes, termed mytoxins D-G (1-4), along with four known analogs (5-8), were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus Myrothecium verrucaria PA57. Each compound features a tricyclic 12,13-epoxytrichothec-9-ene (EPT) core. Notably, mytoxin G (4) represents the first instance of a macrocyclic trichothecene incorporating a glucosyl unit within the trichothecene structure.

Arabidopsis thaliana YUC1 reduced fluoranthene accumulation by modulating IAA content and antioxidant enzyme activities.

Indole-3-acetic acid (IAA) can regulate plant growth and thus modulate the accumulation of polycyclic aromatic hydrocarbons (PAHs). However, the effect of endogenous IAA on PAHs accumulation and its influencing factors remains unclear. To unravel this, two different IAA expression genotypes of Arabidopsis thaliana, i.