Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography.

Background: The retina serves as a non-invasive window to visualize systemic health, with optical coherence tomography angiography (OCTA) enabling simultaneous assessment of retinal structural thickness and vascular density. Suboptimal cardiovascular-kidney-metabolic (CKM) health status, defined by the early stage of CKM syndrome, may impact retinal neurovascular integrity, yet comprehensive OCTA-based evaluations remain limited and controversial. This study aimed to investigate retinal structural and vascular alterations in the early-stage CKM using OCTA and explore its potential as a biomarker tool.

Ovatodiolide alleviates renal fibrosis through regulating metabolic reprogramming via targeting glucose-6-phosphate dehydrogenase.

Background: Ovatodiolide (Ova) is a bioactive compound from Anisomeles indica (l.) Kuntze, which has been traditionally utilized to tonify the kidney function. There is limited targeted therapies available for renal fibrosis (RF) in chronic kidney disease (CKD).

Untargeted metabolomics reveals homogeneity and heterogeneity between physiological and pathological ovarian aging.

Background: Ovarian aging is the main cause of reduced reproductive life span, yet its metabolic profiles remain poorly understood. This study aimed to reveal the metabolic homogeneity and heterogeneity between physiological and pathological ovarian aging.

Methods: Seventy serum samples from physiological ovarian aging participants, pathological ovarian aging participants (including diminished ovarian reserve (DOR), subclinical premature ovarian insufficiency (scPOI) and premature ovarian insufficiency (POI)), as well as healthy participants were collected and analyzed by untargeted metabolomics.

Core-shell structured waste paper/biocarbon composite providing exceptional electromagnetic interference shielding and flame retardancy.

The widespread use of electronic devices significantly facilitates daily human life, but also leads to increasingly serious electromagnetic pollution. Therefore, it is necessary to develop eco-friendly electromagnetic interference (EMI) shielding materials with excellent overall performance. Here, we prepare a waste paper/biocarbon (WP/BC) composite with a distinct densely self-bonded core-shell structure through the partial dissolution co-mixing process.

The impact of lymph node dissection on stage I ovarian endometrioid carcinoma: A US-China Comparative Analysis.

This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database conducted in USA and NUWA database in China, we found that patients who underwent LND in the SEER cohort exhibited significantly improved long-term survival rates compared to those who did not undergo LND, while the difference was not statistically significant in the NUWA cohort. Cox regression and restricted cubic spline analyses indicated an inverted U-shaped association between the number of LNDs and hazard ratios, identifying 29-34 lymph nodes as the optimal range.

Zuogui pills ameliorate chemotherapy-induced ovarian aging by improving stemness, regulating cell cycle and reducing apoptosis of oogonial stem cells via the Notch1/Nrf2 pathway.

Ethnopharmacological Relevance: Zuogui Pills (ZGP) is a classic traditional Chinese herbal formula originating from the Ming Dynasty. It has been widely used in the treatment of kidney deficiency-related diseases, including ovarian aging.

Aim Of The Study: To investigate the effects and potential mechanisms of ZGP on ovarian aging induced by the chemotherapeutic agent cyclophosphamide (CTX), as well as its impact on the therapeutic target, oogonial stem cells (OSCs), involving the Notch1/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.

HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis.

Background: Ferroptosis, a newly identified form of regulated cell death triggered by small molecules or specific conditions, plays a significant role in virus-associated carcinogenesis. However, whether tumours arising after high-risk HPV integration are associated with ferroptosis is unexplored and remains enigmatic.

Methods: High-risk HPV16 integration was analysed by high-throughput viral integration detection (HIVID).

Sustainable design of photo-Fenton-like oxidation process in actual livestock wastewater through the highly dispersed FeCl anchoring on a g-CN substrate.

Photocatalytic technology emerges as a promising solution for the sustainable treatment of contaminated wastewater. However, the practical implementation of designed photocatalysts often faces challenges due to the intricate 'high carbon footprint' process and limited outdoor laboratory investigations. Herein, a simple yet versatile impregnation approach is proposed to anchor highly dispersed FeCl on a g-CN substrate (Fe-CN) with minimal energy consumption and post-processing.

Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with nonalcoholic simple fatty liver disease: a randomized controlled trial.

Background: Our previous studies showed that curcumin prevented hepatic steatosis in animal models.

Objectives: This study aimed to assess the effects of curcumin on hepatic fat content, body composition, and gut microbiota-dependent bile acid (BA) metabolism in patients with nonalcoholic simple fatty liver (NASFL).

Methods: In a 24-wk double-blind randomized trial, 80 patients with NASFL received 500 mg/d curcumin or placebo.

Perception Methods for Adverse Weather Based on Vehicle Infrastructure Cooperation System: A Review.

Environment perception plays a crucial role in autonomous driving technology. However, various factors such as adverse weather conditions and limitations in sensing equipment contribute to low perception accuracy and a restricted field of view. As a result, intelligent connected vehicles (ICVs) are currently only capable of achieving autonomous driving in specific scenarios.

Different crystalline manganese dioxide and biochar co-conditioning aerobic composting: Reduced ammonia volatilization and improved organic fertilizer quality.

Aerobic composting is a sustainable and effective waste disposal method. However, it can generate massive amounts of ammonia (NH) via volatilization. Effectively reducing NH volatilization is vital for advancing aerobic composting and protecting the ecological environment.

Amelioration of Atherosclerosis by lycopene is linked to the modulation of gut microbiota dysbiosis and related gut-heart axis activation in high-fat diet-fed ApoE mice.

Background: Interplay between gut microbiota and heart, termed "gut-heart" axis, has a crucial role in the pathogenesis of atherosclerosis. Our previous study showed that lycopene possesses anti-inflammatory and anti-atherosclerotic effects, but its link to the gut microbiota is poorly understood. Herein, we surmised that lycopene could regulate the gut microbiota, exert anti-atherosclerotic effect by regulating the "gut-heart" axis.

A novel porous lignocellulosic standing hierarchical hydroxyapatite for enhanced aqueous copper(II) removal.

Potentially toxic metal-polluted water resources are a heavily discussed topic the pollution by potentially toxic metals can cause significant health risks. Nanomaterials are actively developed towards providing high specific surface area and creating active adsorption sites for the treatment and remediation of these polluted waters. In an effort to tackle the limitations of conventional type adsorbents, nano-hydroxyapatite (HAp) was developed in this study by in situ generation onto wood powder, resulting in the formation of uniform hybrid powder (HAp@wood composite) structure consisting of HAp nanoparticles that showed the removal efficiency up to 80 % after 10 min; the maximum adsorption capacity for Cu(II) ions (98.

Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.

Podocyte damage is the major cause of glomerular injury and proteinuria in multiple chronic kidney diseases. Metadherin (MTDH) is involved in podocyte apoptosis and promotes renal tubular injury in mouse models of diabetic nephropathy and renal fibrosis; however, its role in podocyte injury and proteinuria needs further exploration. Here, we show that MTDH was induced in the glomerular podocytes of patients with proteinuric chronic kidney disease and correlated with proteinuria.

Removing DOM from chloride modified hydrochar could improve Cu adsorption capacity from aqueous solution.

The behavior and composition of hydrochar-based dissolved organic matter (DOM) would affect the efficiency of copper (Cu) removal from wastewater through adsorption. In this study, the reed was hydrolyzed in the presence of feedwater with and without ZnCl, FeCl, and SnCl to produce pristine hydrochars (PHCs), which were named HO-HC, ZnCl-HC, FeCl-HC, and SnCl-HC. After removal of DOM, washed hydrochars (WHCs) were obtained, labelled as W-HO-HC, W-ZnCl-HC, W-FeCl-HC, and W-SnCl-HC.

Advances in gum-based hydrogels and their environmental applications.

Gum-based hydrogels (GBHs) have been widely employed in diverse water purification processes due to their environmental properties, and high absorption capacity. More desired properties of GBHs such as biodegradability, biocompatibility, material cost, simplicity of manufacture, and wide range of uses have converted them into promising materials in water treatment processes. In this review, we explored the application of GBHs to remove pollutants from contaminated waters.

Niacin/β-hydroxybutyrate regulates milk fat and milk protein synthesis the GPR109A/G/mTORC1 pathway.

As a crucial receptor of BHBA and niacin, GPR109A is largely expressed in the mammary gland. However, the role of GPR109A in milk synthesis and its underlying mechanism is still largely unknown. In this study, we first investigated the effect of GPR109A agonists (niacin/BHBA) on milk fat and milk protein synthesis in a mouse mammary epithelial cell line (HC11) and PMECs (porcine mammary epithelial cells).

Effects of Lysine on the Interfacial Bonding of Epoxy Resin Cross-Linked Soy-Based Wood Adhesive.

Soy protein isolate (SPI) is an attractive natural material for preparing wood adhesives that has found broad application. However, poor mechanical properties and unfavorable water resistance of wood composites with SPI adhesive bonds limit its more extensive utilization. The combination of lysine (Lys) with a small molecular structure as a curing agent for modified soy-based wood adhesive allows Lys to penetrate wood pores easily and can result in better mechanical strength of soy protein-based composites, leading to the formation of strong chemical bonds between the amino acid and wood interface.

A Dynamic Lane-Changing Driving Strategy for CAV in Diverging Areas Based on MPC System.

Freeway-diverging areas are prone to low traffic efficiency, congestion, and frequent accidents. Because of the fluctuation of the surrounding traffic flow distribution, the individual decision-making of vehicles in diverging areas is typically unable to plan a departure trajectory that balances safety and efficiency well. Consequently, it is critical that vehicles in freeway-diverging regions develop a lane-changing driving strategy that strives to improve both the safety and efficiency of divergence areas.

Remediation competence of nanoparticles amalgamated biochar (nanobiochar/nanocomposite) on pollutants: A review.

Advanced biochar blended nanoparticles substances, such as nano biochar or nanocomposites, have provided long-term solutions to a wide range of modern-day problems. Biochar blended nano-composites can be created to create better composite materials that combine the benefits of biochar and nanoparticles. Such materials have been typically improved with active functional groups, porous structure, active surface area, catalytic deterioration ability, as well as easy recovery or separation of pollutants.

Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus.

Background: Gestational diabetes mellitus (GDM) places both the mother and offspring at high risk of complications. Increasing evidence suggests that the gut microbiota plays a role in the pathogenesis of GDM. However, it is still unclear whether the gut microbiota is related to blood biochemical traits, particularly glucagon-like peptide-1 (GLP-1), in GDM patients.

Facile synthesis of biogenic palladium nanoparticles using biomass strategy and application as photocatalyst degradation for textile dye pollutants and their in-vitro antimicrobial activity.

Among biological applications, plant-mediated Pd NPs for multi-drug resistance (MDR) developed in pathogenic bacteria were synthesized with the help of biomass of lemon peel, a biological material, with a non-toxic, environmentally friendly, human-nature green synthesis method. Characterization of synthesized Pd NPs was carried out by UV-Vis spectrometry, Transmissive Electron Microscopy (TEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) techniques. According to TEM analysis, Pd NPs were confirmed to be in a spherical shape and the mean particle size was determined to be 4.

Dynamic miRNA Landscape Links Mammary Gland Development to the Regulation of Milk Protein Expression in Mice.

Mammary gland morphology varies considerably between pregnancy and lactation status, e.g., virgin to pregnant and lactation to weaning.