On-liquid surface synthesis of diyne-linked two-dimensional polymer crystals.

The synthesis of thin crystalline two-dimensional polymers (2DPs) typically relies on reversible dynamic covalent reactions. While substantial progress has been made in solution-based and interfacial syntheses, achieving 2DPs through irreversible carbon-carbon coupling reactions remains a formidable challenge. Herein, we present an on-liquid surface (a mixture of N,N-dimethylacetamide and water, DMAc-HO) synthesis method for constructing diyne-linked 2DP (DY2DP) crystals via Glaser coupling, assisted by a perfluoro-surfactant (PFS) monolayer.

ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search.

In a multicellular organism, cell lineages share a common evolutionary history. Knowing this history can facilitate the study of development, aging, and cancer. Cell lineage trees represent the evolutionary history of cells sampled from an organism.

Hydroxy-Methylated Lignin for the Preparation of UV Shielding PVA/Lignin Films.

Traditional plastic films have caused serious environmental issues due to "white pollution". This study isolates lignin from cottonseed hulls to explore alternatives to plastic films. Using both cottonseed hull lignin and commercially sourced white lignin as raw materials, we performed hydroxy-methylation modification via physical and chemical cross-linking to obtain hydroxy-methylated cottonseed hull lignin and hydroxy-methylated white lignin, resulting in hydroxy-methylated lignin with improved hydrophilicity.

An examination of online physical education participation and its effects on health promotion.

Introduction: The COVID-19 epidemic significantly impacted global education patterns. To protect the health of students, many countries and regions implemented online curricula during the peak of the epidemic, allowing teaching to continue despite the suspension of classes. However, whether all subjects, such as physical education (PE), can be effectively learned online is worth exploring.

Associations Between Body Roundness Index and Cardiovascular Outcomes: A China Kadoorie Biobank Prospective Cohort Study.

Background: Obesity traditionally scaled by body mass index, and visceral fat are independent risk factors for cardiovascular diseases (CVDs). Assessing obesity's impact on CVDs based solely on height or weight can be inaccurate. The body roundness index (BRI) estimates visceral fat distribution, but its association with CVDs in large-scale Chinese cohort remained unexplored.

Metal-Organic Frameworks (MOFs)-Derived Mesoporous Carbon Encapsulated Ultrafine Scandium Oxide Electrocatalyst for Highly Efficient Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid.

Green electrochemical synthesis of 2,5-furandicarboxylic acid (FDCA) from biomass is an essential alternative for the substitution of petroleum-based terephthalic acid. The rational design and application of high-performance electrocatalysts are the key to advance this technique. In this work, mesoporous carbon encapsulated ultrafine ScO nanoparticles are reported as a new, highly efficient and selective electrocatalyst that realizes the concurrent electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to FDCA coupled with hydrogen evolution.

GPS: Harnessing data fusion strategies to improve the accuracy of machine learning-based genomic and phenotypic selection.

Genomic selection (GS) and phenotypic selection (PS) are widely used for accelerating plant breeding. However, the accuracy, robustness, and transferability of these two selection methods are underexplored, especially when addressing complex traits. In this study, we introduce a novel data fusion framework, GPS (genomic and phenotypic selection), designed to enhance predictive performance by integrating genomic and phenotypic data through three distinct fusion strategies: data fusion, feature fusion, and result fusion.

Review of Cu-based Dual-Site Catalysts for Multi-Step Nitrate Reduction: Bridging Material Properties and Catalytic Mechanisms through Strategic Design.

Dual-site catalysts exhibit a range of catalytic properties and coordination synergies, providing an ideal reaction platform for multi-step electrocatalytic nitrate reduction reactions (NORR). The preparation of dual-site catalysts requires creating two distinct reaction sites, leading to various synthesis methods. Introducing movable reaction sites can also modify the original atomic arrangement, triggering changes in the electron distribution of materials.

EGFR exon 20 insertions mutation in lung adenocarcinoma and its response by high-dose of Furmonertinib: a real-world study.

Background: LUAD patients with EGFR exon 20 insertions (ex20ins) have a poorer prognosis than those with EGFR 19del or L858R mutations. The FAVOUR study showed high-dose furmonertinib's efficacy in ex20ins patients. However, more real-world data are needed to validate these findings.

Small-scale heterogeneity of soil properties in farmland affected fava beans growth through rhizosphere differential metabolites and microorganisms.

Background: Soil heterogeneity has been acknowledged to influence plant growth, with the small-scale soil heterogeneity always being overlooked in practice. It remains unclear how rhizosphere soil biotics and abiotics respond to soil heterogeneity and how rhizosphere interactions influence crop growth.

Results: In this study, we planted fava beans in a farmland around an e-waste dismantling site, and a distinct boundary (row spacing is 30 cm) was observed in the field during the flowering stage, which divided fava beans phenotypes into two distinct groups (Big vs Little) based on the differences in biomass and height.

Monotherapy and combination therapy using antibody‑drug conjugates for platinum‑resistant ovarian cancer.

Platinum‑resistant ovarian cancer (PROC) is a significant clinical challenge due to the limited number of treatment options and poor outcomes. Moreover, cytotoxic drugs have an unsatisfactory therapeutic efficacy, high toxicity and side effects. An antibody‑drug conjugate (ADC) is a novel cancer therapeutic strategy that combines an antibody, a linker and a payload.

Interfacial-Free-Water-Enhanced Mass Transfer to Boost Current Density of Hydrogen Evolution.

The advancement of water electrolysis highlights the growing importance of electrolyzers capable of operating at high current densities, where mass transfer dynamics plays a crucial role. In the electrode reactions, the interfacial water is a key factor in regulating these dynamics. However, the potential of utilizing interfacial-free water (IFW) to modulate electrode behavior remains underexplored.

Diagnostic Value of Umbilical Cord Blood Interleukin-6 Level in Premature Infants with Early-Onset Sepsis.

Objective: Early-onset sepsis (EOS) is a serious, grave, and frequently fatal condition in premature infants. This study aimed to assess the diagnostic value of interleukin-6 (IL-6) levels in umbilical cord blood for identifying EOS in preterm infants.

Methods: This prospective cohort study was conducted on preterm infants between May 2019 and April 2021.

Biomechanical properties of tetrahedral microstructure for design of the porous stem in total hip arthroplasty.

Different internal strut architectures affect the biomechanical performance of porous lattice structures. This study aims to investigate these properties under various conditions using different methods.The finite element simulations of tetrahedral microstructures were conducted with varying internal strut thicknesses under different loads.

Typical heavy metals in wastewater treatment plants in Nanjing, China: perspective of abundance, removal, and microbial response.

Heavy metals (HMs) are hazardous contaminants with persistence and bioaccumulation, attracting widespread attention. Wastewater treatment plants (WWTPs) play vital roles in the pollution control of sewage, closely related to human health and the biological environment. Therefore, eight HMs in three typical WWTPs of Nanjing were determined in this study.

Mechanism for meeting the care of older adults in rural China-relying on spouse, offspring or community?

Background: Within the population aging and the trend of aging in place on the rise, it is crucial to explore how care needs are being met for this demographic within the community.

Methods: This study utilizes data from the 2019-2021 survey on 1,126 rural older adults aged 60 years and above across 11 provinces and 31 villages in China. This study aims to examine the influence of spouse, offspring, and community status on the extent to which the care needs of rural older adults are met.

Chromatin accessibility mediated by CHROMATIN REMODELING 11 promotes chilling tolerance in rice.

Chromatin remodeling plays a crucial role in controlling gene transcription by modifying chromatin structure. However, the involvement of chromatin remodeling in plant stress responses, especially cold tolerance, through chromatin accessibility remains largely unexplored. Here, we report that rice (Oryza sativa L.

Dynamic Chromatin Accessibility and Gene Expression Regulation During Maize Leaf Development.

Background/objectives: Chromatin accessibility is closely associated with transcriptional regulation during maize () leaf development. However, its precise role in controlling gene expression at different developmental stages remains poorly understood. This study aimed to investigate the dynamics of chromatin accessibility and its influence on genome-wide gene expression during the BBCH_11, BBCH_13, and BBCH_17 stages of maize leaf development.

Photocatalytic acceptorless dehydrogenation of flavanones by cationic Eosin Y as a bifunctional catalyst.

We report the first example of photocatalytic acceptorless dehydrogenation using cationic Eosin Y as a bifunctional photocatalyst, without metal catalysts or HAT reagents. Under Bayesian optimized conditions, a wide range of flavones were synthesized in moderate to excellent yields, many of which were reported with biological activities. Mechanistic studies suggest that flavones likely form through two HAT processes, with hydrogen release occurring photoredox.

Construction of an Sc-NiFe-LDH electrocatalyst for highly efficient electrooxidation of 5-hydroxymethylfurfural at industrial current density.

Renewable electricity-powered electrooxidation of 5-hydroxymethylfurfural (HMFOR) to FDCA offers a green and sustainable approach to producing an essential monomer for bio-polymers, provided that a highly efficient electrocatalyst is present. Herein, we show that the doping of scandium (Sc) into an NiFe-LDH electrocatalyst (Sc-NiFe-LDH) considerably promotes HMFOR by enhancing the formation of high-valence Ni-O active sites, facilitating electron transport and HMF adsorption and suppressing the oxygen evolution reaction. In the presence of the Sc-NiFe-LDH electrocatalyst, an FDCA faradaic efficiency and selectivity of 96.

Efficient recovery of valuable metals from electroplating sludge smelting soot via a combined alkali roasting and acid-free aluminum salts leaching methods.

Electroplating sludge smelting soot (ESSS), contains high-grade value metals (such as Zn, Sn, Pb, precious metals Au and Pt) and large amounts of harmful elements Br and S, which could potentially cause valuable resources wastage and environmental pollution, therefore requires responsible recycling. An efficient and eco-friendly process for the cascade recovery of Zn, Sn, Pb, and precious metals Au and Pt from ESSS was proposed, combining NaOH roasting and acid-free aluminum salts leaching. Optimal NaOH roasting conditions achieved high extraction efficiencies for Zn, Sn, and Pb, which were then separated via water leaching.

Hyperactivity of the IL-33-ILC2s-IL-13-M-MDSCs axis promotes cervical cancer progression.

The interleukin-33(IL-33) - group 2 innate lymphoid cells (ILC2s) - interleukin-13(IL-13) - monocytic myeloid-derived suppressor cells (M-MDSCs) axis plays a critical role in promoting immune evasion in tumors; however, its specific function in cervical cancer remains poorly understood. In this study, we observed that the proportion of IL-33-ILC2s-IL-13-M-MDSCs were significantly elevated in both cervical cancer patients and the subcutaneous U14 cervical cancer mouse model, compared to normal controls. Our results suggest that IL-33 stimulates ILC2s to secrete IL-13, which, in turn, regulates M-MDSCs to enhance their immune evasion capabilities.

Applying cross-scale regulations to Sedum plumbizincicola for strengthening the bioremediation of the agricultural soil that contaminated by electronic waste dismantling and revealing the underlying mechanisms by multi-omics.

Electronic waste dismantling has induced the surrounding agricultural soils suffered from combined contamination of heavy metals and organic pollutants. Lower efficiency and complex mechanisms of bioremediation remain to be resolved. Here, we adopted regulations to Sedum plumbizincicola cross aboveground and belowground scales to strengthen the bioremediation efficiency.

Metabolomic and transcriptomic analyses reveals candidate genes and pathways involved in secondary metabolism in Bergenia purpurascens.

Bergenia purpurascens is an important medicinal, edible and ornamental plant. The lack of omics information hinders the study of its metabolic pathways and related genes. In order to investigate candidate genes and pathways involved in secondary metabolism in B.