Advances in the mechanism of small extracellular vesicles promoting the development of hepatocellular carcinoma through multi-network fusion.

Hepatocellular carcinoma (HCC) is a highly malignant epithelial tumor characterized by global high incidence and poor clinical prognosis. Radical surgical resection, as the standard treatment for early-stage HCC patients, has been extensively validated for its therapeutic efficacy. However, epidemiological studies indicate that most patients are already in advanced stages at initial diagnosis, losing eligibility for radical treatment.

Survival benefit of surgery for inflammatory breast cancer patients.

Background: Inflammatory breast cancer (IBC) is considered as the most aggressive subtype of breast cancer. The purpose of this study is to evaluate the effect of surgical treatments on IBC patients.

Methods: Based on propensity score matching (PSM) analysis, we evaluated the prognostic significance of surgical intervention in patients with IBC by Cox proportional hazard models.

Enhanced fluoride removal from drinking water by activated carbon supported Ce-Al oxides: performance and mechanism.

Elevated fluoride levels in drinking water pose a significant challenge to human health, necessitating affordable and effective adsorbents for fluoride removal. This study presents the synthesis of a Ce-Al binary metal oxide composite adsorbent supported on activated carbon (Ce-Al-O/AC) for the defluoridation of drinking water. The adsorbent, employing the synergistic bimetallic effect, demonstrates robust fluoride removal performance across a wide pH range of 4-10.

Transcranial magnetic stimulation-based neuroplasticity in the treatment of amblyopia.

Background: In recent years, repetitive transcranial magnetic stimulation (rTMS) has shown positive clinical effects in improving neuroplasticity by modulating cortical neural activity, particularly the functional connectivity of visual-related brain regions. This research was aimed to investigate the effects of rTMS on visual function in adult amblyopia and to assess changes in brain neuronal activity before and following remedy using resting-state functional magnetic resonance imaging (rs-fMRI).

New Method: A total of 148 patients with anisometropic amblyopia were enrolled and randomly divided into: intraocular lens (ICL) group and ICL+rTMS group, with 74 cases in each group.

Novel insights into the causal relationship between endocrine-disrupting chemicals and breast cancer mediated by circulating metabolites.

The relationship between endocrine-disrupting chemicals (EDCs) and breast cancer has not been extensively investigated. Although EDCs can disrupt human endocrine system, the underlying mechanism of EDCs on breast cancer requires further exploration. This study aimed to investigate the causal relationship between EDCs and breast cancer through Mendelian randomization (MR) and Generalised Summary-data-based Mendelian Randomization (GSMR) approach.

Clinical advances in kidney autotransplantation: a review.

Kidney autotransplantation is a surgical procedure with multiple indications and advancing technological approaches. Kidney autotransplantation is used to address complex kidney-related diseases including renal vascular lesions, ureteral diseases, tumors, loin pain-hematuria syndrome, and conditions affecting a solitary kidney or both kidneys. Renal artery lesions, including aneurysms and stenoses, often necessitate kidney autotransplantation in cases involving renal artery bifurcation or distant failure of endovascular repair.

Relationship of depression and asthma: a observational and Mendelian randomization study.

Background: Both depression and asthma have a significant impact on the quality of life for individuals. Studies have shown that patients with depression often experience comorbid asthma; however, the precise relationship between these two conditions remains unclear. The objective of this study is to investigate the causal relationship between depression and asthma.

Multi-miRNAs-Mediated Hepatic Lepr Axis Suppression: A Pparg-Dicer1 Pathway-Driven Mechanism in Spermatogenesis for the Intergenerational Transmission of Paternal Metabolic Syndrome.

Bisphenol A (BPA) is an "environmental obesogen" and this study aims to investigate the intergenerational impacts of BPA-induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure to BPA induces metabolic disorders in the paternal mice, which are then transmitted to offspring, leading to late-onset MetS. Mechanistically, BPA upregulates Srebf1, which in turn promotes the Pparg-dependent transcription of Dicer1 in spermatocytes, increasing the levels of multiple sperm microRNAs (miRNAs).

Drug repurposing opportunities for breast cancer and seven common subtypes.

Breast cancer is a substantial global health problem, and drug repurposing provides novel opportunities to address the urgent need for therapeutics. According to significant Mendelian randomization (MR) results, we identified 26 genes for overall breast cancer, 25 genes for ER+ breast cancer and 4 genes (CASP8, KCNN4, MYLK4, TNNT3) for ER- breast cancer. In order to explore the differences between 5 intrinsic subtypes, we found 29 actionable druggable genes for Luminal A breast cancer, 2 genes (IGF2 and TNNT3) for Luminal B breast cancer, 1 gene (FAAH) for Luminal B HER2 negative breast cancer, and 3 genes (CASP8, KCNN4, and TP53) for triple-negative breast cancer.

Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study.

Background: The relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors and prostate cancer is still unknown. Although these inhibitors can influence tumor glycolysis, the underlying mechanism requires further exploration.

Methods: A two-sample two-step MR was used to determine 1) causal effects of SGLT2 inhibition on prostate cancer; 2) causal effects of 1,400 circulating metabolites or metabolite ratios on prostate cancer; and 3) mediation effects of these circulating metabolites.

Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular characteristics using public databases. TCGA pan-cancer dataset was used to analyze DHODH expression in different cancer types and TCGA ccRCC dataset was used to assess differential expression, prognosis correlation, immune infiltration, single-gene, and functional enrichment due to DHODH.

Identification of hub genes and diagnostic efficacy for triple-negative breast cancer through WGCNA and Mendelian randomization.

Objective: Triple-negative breast cancer (TNBC) represents a particularly aggressive form of breast cancer with a poor prognosis due to a lack of targeted treatments resulting from limited a understanding of the underlying mechanisms. The aim of this study was the identification of hub genes for TNBC and assess their clinical applicability in predicting the disease.

Methods: This study employed a combination of weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEGs) to identify new susceptible modules and central genes in TNBC.

Elucidating the relationship between metabolites and breast cancer: A Mendelian randomization study.

The evidence about the causal roles of metabolites in breast cancer is lacking. This study conducted a systematic evaluation of the potential causal relationship between 1091 human blood metabolites, 309 metabolite ratios, and the likelihood of developing breast cancer and its subtype by employing a two-sample bidirectional Mendelian randomization (MR) approach Four metabolites, including tryptophan betaine (Odds Ratio [OR] = 1.07, 95%CI = 1.

Improved Interface Construction on Anode and Cathode for Na-Ion Batteries Using Ultralow-Concentration Electrolyte Containing Dual-Additives.

Compared with Li, Na with a smaller stokes radius has faster de-solvation kinetics. An electrolyte with ultralow sodium salt (0.3 M NaPF) is used to reduce the cell cost.

Elucidating the relationship between breast cancer and brain cortical structure: a Mendelian randomization study.

Cancer-associated cognitive impairment is a significant challenge for individuals who have survived breast cancer, affecting their quality of life. In this study, we conducted an inaugural comprehensive Mendelian randomization analysis discerning the causal relationship between breast cancer, including its two subtypes, and the cerebral cortical structure. Our analysis indicated that estrogen receptor-negative breast cancer significantly decreased surface area (β = -593.

Nanoplastic propels diet-induced NAFL to NASH via ER-mitochondrial tether-controlled redox switch.

Nonalcoholic steatohepatitis (NASH) is multifactorial that lifestyle, genetic, and environmental factors contribute to its onset and progression, thereby posing a challenge for therapeutic intervention. Nanoplastic (NP) is emerged as a novel environmental metabolism disruptor but the etiopathogenesis remains largely unknown. In this study, C57BL/6 J mice were fed with normal chow diet (NCD) and high-fat diet (HFD) containing 70 nm polystyrene microspheres (NP).

Unique Tridentate Coordination Tailored Solvation Sheath Toward Highly Stable Lithium Metal Batteries.

Electrolyte optimization by solvent molecule design is recognized as an effective approach for stabilizing lithium (Li) metal batteries. However, the coordination pattern of Li ions (Li ) with solvent molecules is sparsely considered. Here, an electrolyte design strategy is reported based on bi/tridentate chelation of Li and solvent to tune the solvation structure.

A mixed-ligand Co(II) MOF synthesized from a single organic ligand to capture iodine and methyl iodide vapour.

Mixed-ligand metal-organic frameworks (MOFs) are usually synthesized from two or more organic ligands as initial reactants, and MOFs synthesized from one organic ligand precursor through partial reactions remain very limited. Herein, by introducing an imidazole-tetrazole bifunctional ligand, 5-(4-imidazol-1-yl-phenyl)-2-tetrazole (HIPT), as a single ligand and performing hydrolysis of the tetrazolium group, a mixed-ligand Co(II)-MOF based on HIPT and 4-imidazol-1-yl-benzoic acid (HIBA), [Co(μ-O)(IPT)(IBA)]· solvent (Co-IPT-IBA), was constructed and applied to capture I and methyl iodide vapours. Single crystal structural analyses reveal that Co-IPT-IBA exhibits a 3D porous framework with 1D channels based on the relatively few reported ribbon-like rod SBUs.

DEMOC: a deep embedded multi-omics learning approach for clustering single-cell CITE-seq data.

Advances in single-cell RNA sequencing (scRNA-seq) technologies has provided an unprecedent opportunity for cell-type identification. As clustering is an effective strategy towards cell-type identification, various computational approaches have been proposed for clustering scRNA-seq data. Recently, with the emergence of cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq), the cell surface expression of specific proteins and the RNA expression on the same cell can be captured, which provides more comprehensive information for cell analysis.

Excavating Anomalous Capacity Increase of Li-S Pouch Cells by Electrochemical Oscillation Formation.

The insufficient activation of a S/C cathode makes insufficient utilization of S in Li-S pouch cells, while the deep activation of a S/C cathode in a formation process is time-consuming and produces lithium polysulfides, which corrode a Li anode. Both situations lead to a low actual capacity of the Li-S pouch cells with a high S loading but are ignored for coin cells. In this work, electrochemical oscillation (EOS) formation employing hundreds of shallow discharge/charge cycles with high frequency was used to replace the resting and/or one deep discharge/charge cycle of traditional (TD) formation protocols.

First identification of two co-existing genome-wide significant sex quantitative trait loci (QTL) in red tilapia using integrative QTL mapping.

Red tilapia ( spp ) is one of the most popular fish in China due to its bright red appearance, fast growth rate, and strong adaptability. Understanding the sex determination mechanisms is of vital importance for the selection of all-male lines to increase aquacultural production of red tilapia. In this research, the genetic architecture for sex from four mapping populations ( =1 090) of red tilapia was analyzed by quantitative trait loci (QTL)-seq, linkage-based QTL mapping, and linkage disequilibrium (LD)-based genome-wide association studies.