Workplace mindfulness and clinical belongingness among nursing interns: The mediating role of subjective well-being.

Background: The sense of clinical belongingness significantly impacts the mental health of undergraduate nursing interns. Workplace mindfulness and subjective well-being are considered key factors influencing clinical belonging. Currently, there is no research elucidating how workplace mindfulness and subjective well-being affect clinical belonging.

MCC950 Alleviates Fat Embolism-Induced Acute Respiratory Distress Syndrome Through Dual Modulation of NLRP3 Inflammasome and ERK Pathways.

Fat embolism is a critical medical emergency often resulting from long bone fractures or amputations, leading to acute respiratory distress syndrome (ARDS). The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, a key regulator of innate immunity, is activated by reactive oxygen species and tissue damage, contributing to inflammatory responses. This study examines the role of NLRP3 in fat embolism-induced ARDS and evaluates the therapeutic potential of MCC950, a selective NLRP3 antagonist.

Global trends and hotspots of adolescent eating disorders: a bibliometric study and visual analysis.

Background: Adolescent eating disorders represent a category of mental illness, marked by elevated mortality and morbidity rates and a significant adverse impact on the quality of life of both patients and their families. As one of the most important directions in eating disorders, adolescent eating disorders have significant research value, social value, and practical significance. Surprisingly, the overall research landscape in this domain has yet to be systematically explored through bibliometric analysis.

Characterisation of the Novel HLA-C*03:714 Allele by Next-Generation Sequencing.

HLA-C*03:714 differs from HLA-C*03:04:01:01 by one nucleotide substitution at position 685G>A in exon 4.

Biodegradable sustained-release microneedle patch loaded with clindamycin hydrochloride: a breakthrough in acne management.

Background: Clindamycin hydrochloride, a first-line antibiotic for acne treatment, faces challenges with poor skin penetration due to its hydrophilicity and the barrier posed by the stratum corneum. To address this limitation, we developed gelatin-methacryloyl (GelMA) hydrogel-based biodegradable microneedles (GM-Clin-MN) for sustained intradermal drug delivery, thereby enhancing therapeutic efficacy.

Methods: The microneedle patches loaded with 1 wt% clindamycin hydrochloride were fabricated using PDMS molds and characterized through scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and fluorescence microscopy.

Protoberberine alkaloids from Berberis pruinosa and their antimalarial activities.

Three new protoberberine alkaloids berpruines A-C (1, 2, and 4), along with six known compounds and one isolation artifact (9) from the 95 % EtOH extract of roots of Berberis pruinosa. Their structures were determined by the comprehensive analyses of the spectroscopic data (1D NMR, 2D NMR, HRESIMS, and CD) and physicochemical properties, and berpruine C (4) as the first example of 2,3,9,10,12 pentasubstituted protoberberine alkaloid from plants. Compounds 4, 5, 7, and 10 exhibited significant in vitro antimalarial activities with IC values of 5.

Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention.

Purpose: Subthreshold depression (SD) is a highly prevalent mental health condition and a key precursor in major depressive disorder. Internet-based cognitive behavioral therapy (ICBT) effectively treats SD in clinical settings, but the neuromechanisms behind its success are not fully understood. This study aimed to examine changes in intrinsic brain activity in SD and their further alterations after ICBT intervention.

Relationship between uncertainty in illness and fear of progression among lung cancer patients: The chain mediation model.

Background: Uncertainty in illness (UI) and fear of progression (FoP) are significant psychological challenges for lung cancer patients. Coping styles and social support are critical mediators, influencing patients' ability to manage the emotional and psychological burden of UI and FoP. However, limited research has explored the chain mediation effect of these factors on the relationship between UI and FoP, particularly among Chinese lung cancer patients.

Prognostic effect of body roundness index on all-cause mortality among US older adults.

The Body Rounds Index (BRI) is an anthropometric indicator specifically developed to evaluate an individual's obesity level, particularly emphasizing central or abdominal obesity. This study aimed to explore the relationship between BRI and all-cause mortality in older U.S.

Ten eudesmane sesquiterpenoids from Dobinea delavayi and their antimalarial and lipid-lowering activities.

Ten undescribed eudesmane sesquiterpenoids dobinins AB-AJ (1-10) were isolated from Dobinea delavayi, and their structures were identified by extensive spectroscopic data analyses. Dobinin AB (1) is the first sesquiterpenoid alkaloid isolated from Anacardiaceae. The in vitro antimalarial activities against Plasmodium falciparum 3D7 and lipid-lowering activities of all compounds were evaluated.

Understanding how agroforestry systems biodiversity drives ecosystem services in degraded habitats.

Agroforestry (AF) systems are widely implemented in degraded habitats owing to their potential for ecological restoration. However, the mechanisms by which different levels of biodiversity-taxonomic diversity (TD) and functional diversity (FD)influence ES provisioning along degradation gradients remain unclear. This study examined three habitat types in the karst region of southern China: non-degraded (KND), potentially lightly degraded (PKD), and moderately to heavily degraded (MKD).

Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy.

Purpose: Patients with subthreshold depression (sD) carry a significant risk of developing major depressive disorder. However, few studies focus on the influence of Internet-based Cognitive Behavioral Therapy (ICBT) on brain network, particularly among Chinese undergraduates. This study aims to conduct resting-state functional MRI (rs-fMRI) to explore the effects of ICBT on neurofunctional network.

A Compound Screen Based on Isogenic hESC-Derived β Cell Reveals an Inhibitor Targeting ZnT8-Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress-Induced Cell Death.

Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of cellular stress regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive cellular stress in pancreatic β cells in diabetes.

Loop diuretics mitigate juvenile immobilization treatment-induced hippocampal dysfunction.

Juvenile traumatic experiences can lead to adult cognitive impairments, including learning deficits and increased anxiety risk. Dysfunction of the hippocampus is crucial in stress-induced behavioral disorders, and recent evidence suggests that disrupted chloride homeostasis through the chloride transporter NKCC1 may alter GABAergic signaling and contribute to neuropathology. This study investigates the role of NKCC1 in long-term hippocampal dysfunction induced by juvenile immobilization (J_IMO).

A pathway study of factors influencing anxiety in patients with gestational diabetes mellitus.

Background: This study aims to assess anxiety severity among patients with and to elucidate the predominant psychological factors, informing the development of targeted anxiety management strategies.

Methods: The cross-sectional study recruited 421 GDM patients via convenience sampling from Guangdong Province, China. Self-administered questionnaires, including the Pregnancy-related Anxiety Scale, Simplified Coping Style Questionnaire, Type D Personality Scale, Perceived Social Support Scale, and General Self-Efficacy Scale, were utilized to gather data.

Associations of chronic kidney disease with hidradenitis suppurativa: A bidirectional Mendelian randomization study.

Observational studies have indicated an association between chronic kidney disease (CKD) and hidradenitis suppurativa (HS). Nevertheless, causality remains unclear. Bidirectional Mendelian randomization (MR) analyses were conducted to investigate the direction of association between CKD and HS.

A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties.

Bone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine/PDA@BNNT (PGBT) membrane has improved mechanical and biocompatible properties and generate piezovoltages of 130 mV when activated by ultrasound stimulation under 100 mW/cm without extra polarization.

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection.

DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS-Cav1, SC-TM, and DS2.

New Diagnoses of Juvenile Idiopathic Arthritis Early in the COVID-19 Pandemic: Analysis of a Large United States Commercial Insurance Database.

Background/objective: Little is known about the rates of rheumatic disease diagnosis among children during the COVID-19 pandemic. We examined the impact of the pandemic on the diagnosis of juvenile idiopathic arthritis (JIA) in the United States.

Methods: We performed a historical cohort study using US commercial insurance data (2016-2021) to identify children aged <18 years without prior JIA diagnosis or treatment in the prior ≥12 months.

Correlation between ethical sensitivity and humanistic care ability among undergraduate nursing students: a cross-sectional study.

Background: In nursing practice, a high level of ethical sensitivity and humanistic care ability must always be maintained. A limited number of studies have investigated the correlation between the level of ethical sensitivity and humanistic care ability of nursing students.

Methods: A survey study was conducted from November 2023 to January 2024 among 656 undergraduate nursing students using the General Information Questionnaire, Ethical Sensitivity Questionnaire For Nursing Students, and Humanistic Care Ability Inventory.

Efficient activation of peracetic acid by defect-engineered MoO: Oxygen vacancies and surface Mo(Ⅴ)-mediated electron transfer processes.

The role of defect regulation of transition metal catalysts in peracetic acid (PAA) activation is equivocal. To reveal the corresponding mechanism, this work provides a high-efficiency and eco-friendly catalyst (MoO) for PAA activation by introducing various degrees of oxygen vacancies on the MoO surface. Interestingly, 95.